Data across EXPLORER-HCM, MAVA-LTE and PIONEER-OLE add to the growing body of evidence from the CAMZYOS® (mavacamten) development program, reinforcing the therapeutic value and benefit to patients

PRINCETON, N.J.--(BUSINESS WIRE)-- Bristol Myers Squibb (NYSE: BMY) today announced the presentation of research supporting the company’s cardiovascular franchise at the American College of Cardiology (ACC) Annual Scientific Session & Expo together with the World Congress of Cardiology (WCC), taking place in-person and virtually March 4-6, 2023. Findings from clinical studies will be featured, including several moderated poster presentations from the CAMZYOS® (mavacamten) development program showcasing data across various subgroups of patients with obstructive hypertrophic cardiomyopathy (HCM). During the meeting, the Bristol Myers Squibb-Pfizer Alliance will also present results characterizing the healthcare provider perspective on consumer wearables for atrial fibrillation detection.

“At this year’s ACC, we are proud to showcase both short and long-term data that continues to exemplify our mission of developing and delivering medicines that make a real difference in the lives of cardiovascular patients,” said Roland Chen, MD, senior vice president and head of cardiovascular development, Global Drug Development at Bristol Myers Squibb. “We look forward to presenting CAMZYOS 156-week data, the longest study of any myosin inhibitor, and additional analyses across a variety of patient subgroups, reinforcing its therapeutic value and benefit to patients.”

Key presentations include:

• Updated results from PIONEER-OLE evaluating 13 mavacamten patients through 156 weeks (three years) of follow-up — the longest study of mavacamten treatment to-date in patients with obstructive HCM.
• An exploratory analysis of longitudinal cardiac magnetic resonance data from the EXPLORER cohort of the ongoing MAVA-LTE study that evaluated the effects of long-term treatment (96 weeks) with mavacamten on cardiac remodeling and its impact on left ventricular hypertrophy, which is a key attribute and complication related to HCM.
• Multiple subgroup analyses of the Phase 3 EXPLORER-HCM trial measuring mavacamten’s impact across disease severity, patient age and sex, and duration of diagnosis.
• Results from a Bristol Myers Squibb-Pfizer Alliance sponsored survey characterizing healthcare provider experiences and perceptions of consumer wearable devices for atrial fibrillation detection.

Summary of Presentations

Select Bristol Myers Squibb and Bristol Myers Squibb-Pfizer Alliance studies at ACC.23/WCC include:

*Sponsored by the Bristol Myers Squibb-Pfizer Alliance

About CAMZYOS (mavacamten)

CAMZYOS (mavacamten) is the first and only cardiac myosin inhibitor approved in the U.S., indicated for the treatment of adults with symptomatic New York Heart Association (NYHA) class II-III obstructive hypertrophic cardiomyopathy (HCM) to improve functional capacity and symptoms. It has also received regulatory approvals in Australia, Canada, and Brazil. CAMZYOS is an allosteric and reversible inhibitor selective for cardiac myosin. CAMZYOS modulates the number of myosin heads that can enter “on actin” (power-generating) states, thus reducing the probability of force-producing (systolic) and residual (diastolic) cross-bridge formation. Excess myosin actin cross-bridge formation and dysregulation of the super-relaxed state are mechanistic hallmarks of HCM. CAMZYOS shifts the overall myosin population towards an energy-sparing, recruitable, super-relaxed state. In HCM patients, myosin inhibition with CAMZYOS reduces dynamic left ventricular outflow tract (LVOT) obstruction and improves cardiac filling pressures.

IMPORTANT SAFETY INFORMATION

WARNING: RISK OF HEART FAILURE

CAMZYOS reduces left ventricular ejection fraction (LVEF) and can cause heart failure due to systolic dysfunction.

Echocardiogram assessments of LVEF are required prior to and during treatment with CAMZYOS. Initiation of CAMZYOS in patients with LVEF