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Emgality® Shows Improvement in Work Productivity and Health and Well-Being Between Attacks in Patients with Migraine and a History of Preventive Treatment Failure

Published: 2020-05-26 10:45:00 ET

INDIANAPOLIS, May 26, 2020 /PRNewswire/ -- Emgality® (galcanezumab-gnlm) significantly improved work productivity and reduced interictal burden, defined as health and well-being between migraine attacks, in an analysis of the 3-month double-blind period of the CONQUER study, which included patients with migraine from 12 different countries. The Phase 3 CONQUER study evaluated the efficacy and safety of Emgality for the preventive treatment of episodic and chronic migraine in patients with documented previous treatment failures on two to four different standard-of-care migraine preventive medication categories, due to inadequate efficacy or for safety/tolerability reasons.

"Migraine imposes a profoundly debilitating burden, including interference with work and compromises to social life, that extends beyond the duration of the attacks themselves. At Lilly, we believe that patients and practitioners should expect more from their preventive migraine treatments," said Gudarz Davar, M.D., vice president, neurology development, Lilly Bio-Medicines. "In this important analysis of the clinical trial data, patients reported that Emgality improved their day-to-day functioning and work productivity."

Absenteeism (unplanned absence from work), presenteeism (impairment while working), overall work productivity loss and activity impairment (non-work related) were measured using the migraine-specific Work Productivity and Activity Impairment Questionnaire (WPAI). The burden between headache attacks (interictal burden) in four key areas, including disruption at work and school, diminished family and social life, difficulty planning, and emotional difficulty, was measured using the Migraine Interictal Burden Scale (MIBS) which is a 12 point scale (categories: 0 none, 1-2 mild, 3-4 moderate and >5 severe).

Among the 462 patients randomized to Emgality (n=232) or placebo (n=230), there were statistically significant improvements in work productivity (WPAI) and reductions in overall work productivity loss for the Emgality group compared with placebo (-14.3% vs -3.5%; p

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All statements made via social media sites sponsored or maintained by Enhanced Investments and its affiliates are for informational purposes only and do not constitute a comprehensive description of Enhanced Investments' investment advisory services.
Certain investments are not suitable for all investors. Before investing, consider your investment objectives and applicable fees. The rate of return on investments can vary widely over time, especially for long term investments. Investment losses are possible, including the potential loss of all amounts invested. Information provided by Enhanced Investments is for informational and general educational purposes only and is not investment or financial advice.