Exhibit 99.1

4Q 20 Complete financial statements in IFRS December 31, 2020

(A free translation of the original in Portuguese) Independent auditor’s report To the Board of Directors and Stockholders Itaú Unibanco Holding S.A. Opinion We have audited the accompanying consolidated financial statements of Itaú Unibanco Holding S.A. (“Bank”) and its subsidiaries, which comprise the consolidated balance sheet as at December 31, 2020 and the consolidated statements of income, comprehensive income, and cash flows for the year then ended, and notes to the financial statements, including a summary of significant accounting policies. In our opinion, the consolidated financial statements referred to above present fairly, in all material respects, the consolidated financial position of the Bank and its subsidiaries as at December 31, 2020, and the consolidated financial performance and cash flows for the year then ended, in accordance with the International Financial Reporting Standards (IFRS) issued by the International Accounting Standards Board (IASB). Basis for opinion We conducted our audit in accordance with Brazilian and International Standards on Auditing. Our responsibilities under those standards are further described in the “Auditor’s Responsibilities for the Audit of the Consolidated Financial Statements” section of our report. We are independent of the Bank and its subsidiaries in accordance with the ethical requirements established in the Code of Professional Ethics and Professional Standards issued by the Brazilian Federal Accounting Council, and we have fulfilled our other ethical responsibilities in accordance with these requirements. We believe that the audit evidence we have obtained is sufficient and appropriate to provide a basis for our audit opinion. Key audit matters Key audit matters are those matters that, in our professional judgment, were of most significance in our 2020 audit of the financial statements. Matters These matters were addressed in the context of our audit of the financial statements as a whole, and in forming our opinion thereon, and we do not provide a separate opinion on these matters. Why it is a key audit matter Our 2020 audit was planned and performed considering that the operations of the Bank and its subsidiaries did not present any significant How the changes in relation to the previous year, except for the impacts resulting from matter was the COVID-19 pandemic in the operations. In this context, the Key Audit Matters addressed remained substantially in line with those of the 2019 year end, but incorporating to our audit approach procedures in response to the current scenario of operations. PricewaterhouseCoopers, Av. Francisco Matarazzo 1400, Torre Torino, São Paulo, SP, Brasil, 05001-903, Caixa Postal 60054, T: +55 (11) 3674 2000, www.pwc.com.br

Itaú Unibanco Holding S.A. Why it is a key audit matter Measurement of financial assets and liabilities and provision for expected loss in accordance with IFRS 9—Financial Instruments (Notes 2.3(b), 2.3(f), 2.4(d), 5 to 8 and 10) The provision for expected loss continued to be an area of focus in our audit, as it involves Management’s judgment in determining the necessary provision through the application of methodology and processes which use a variety of assumptions, including, among others, prospective information and criteria for determining a significant increase or decrease in credit risk. In addition, during 2020, as a result of the COVID-19 pandemic, Management revised some of the judgments and estimates used in determining the provision for expected loss, such as the weighting of macroeconomic scenarios, in order to adapt the assumptions previously applied to the current scenario of the operations of the Bank and its subsidiaries. The financial instruments classified as fair value through profit or loss include operations with low liquidity and no active market, which are substantially comprised of securities issued by companies and by derivative contracts. The fair value measurement of these financial instruments involves subjectivity, since it depends on valuation techniques performed based on internal models that include Management assumptions in their fair valuation. Furthermore, market risk management is complex, especially in times of high volatility as observed during 2020 due to the COVID-19 pandemic, as well as in situations where observable prices or market parameters are not available. These matters also continued to be a focus of our 2020 audit due to the relevance and subjectivity mentioned above. How the matter was addressed in the audit We confirmed our understanding of the process of measurement the provision for expected loss and of financial assets and liabilities in accordance with IFRS 9. Regarding the impairment methodology, we performed a number of audit procedures substantially related to the: (i) analysis of management s accounting policies in comparison with IFRS 9 requirements; (ii) testing of controls related to the measurement of the provision for expected loss, which considers data, models and assumptions adopted by Management; (iii) tests on the models, including their approval and validation of assumptions adopted to determine the estimated losses and recoveries. In addition, we tested the guarantees, the projected cash flows, the credit renegotiations, the counterparty’s risk assessment, the payment delays, and other aspects that could result in a significant increase of the credit risk, as well as the classification of operations in their proper stages, pursuant to IFRS 9; (iv) tests on inputs to models and, when available, we compared data and assumptions with market information; and (v) analysis over Management s disclosures in the financial statements in order to comply with IFRS 7—Financial Instruments: Disclosures and IFRS 9. We consider that the criteria and assumptions adopted by management in determining and recording the provision for expected loss are appropriate and consistent, in all material respects, in the context of the consolidated financial statements taken as a whole. Regarding the measurement of financial assets and financial liabilities, we highlight the application of certain audit procedures: (i) analysis of Management’s accounting policies in comparison with IFRS 9 requirements; (ii) update our understanding of the valuation methodology used for these financial instruments and the main assumptions used by Management, as well as comparing them with independent methodologies

Itaú Unibanco Holding S.A. Why it is a key audit matter How the matter was addressed in the audit and assumptions. We performed, on a sample basis, the valuation of certain operations and analyzed the consistency of such methodologies with those applied in prior periods. We believe that the criteria and assumptions adopted by Management to measure the fair value of these financial instruments and derivatives are appropriate and consistent with the disclosures in the accompanying notes to the Financial Statements, considering the consolidated Financial Statements taken as a whole. Information technology environment The Bank and its subsidiaries rely on their As part of our audit procedures, with the support technology structure to process their operations of our specialists, we assessed the information and prepare their financial statements. technology environment, including the automated Technology represents a fundamental aspect on controls of the application systems that are the evolution of the Bank and its subsidiaries’ significant for the preparation of the financial business and, over the last years, significant short statements. and long-term investments have been made in the information technology systems and processes. The procedures performed comprised the combination of relevant tests of design and The technology structure, due to the history of effectiveness of controls and, when necessary, the acquisitions and size of the related operations, is tests of compensating controls, as well as the comprised of more than one environment with performance of tests related to the information different processes and segregated controls. In security, including the access management addition, during 2020, a substantial part of the control, segregation of duties and monitoring the Bank and its subsidiaries’ teams carried out their operating capacity of technology infrastructure in activities remotely (home office), which generated face of the new reality of business operation. the need to adapt technology processes and infrastructure to maintain the continuity of The audit procedures applied resulted in operations. appropriate evidence that was considered in determining the nature, timing and extent of The lack of adequacy of the general controls of the other audit procedures. technology environment and of the controls that depend on technology systems may result in the incorrect processing of critical information used to prepare the financial statements, as well as risks related to information security and cybersecurity. Accordingly, this continued as an area of focus in our audit. Deferred Tax (Notes 2,3(h), 2.4 (j) e 24(b)) The deferred tax assets arising from temporary We confirmed our understanding and tested the differences, income tax losses carryforward and design and the effectiveness of the main controls negative basis of social contribution are recorded established by management to calculate the to the extent Management considers probable deferred tax assets, the recording of such credits

Itaú Unibanco Holding S.A. Why it is a key audit matter How the matter was addressed in the audit that the Bank and its subsidiaries will generate and disclosures in accordance with the accounting future taxable profits sufficient to use these tax standards, including the necessity of analyzing credits. The projection of the future taxable the perspectives for the realization of these assets profits takes into account a number of subjective via projections of future taxable profit for the assumptions established by Management. Bank and its subsidiaries. We continue to consider this an area of focus of We compared the critical assumptions used for our audit, as the use of different assumptions in projecting future results with macroeconomic the projection of future taxable profits, especially information disclosed by the market and with the in the context of impacts on results due to the historical data in order to support the consistency COVID-19 pandemic, could significantly change of these estimates. the amounts and terms expected for the realization of deferred taxes, with consequent With the support of our specialists in the tax area, accounting impact. we performed tests on the nature and amounts of the temporary differences, fiscal losses and negative bases of social contribution, subject to future tax deduction. We believe that the assumptions adopted by Management in the determination and recording of deferred tax assets are appropriate and consistent with the disclosures in the accompanying notes to the financial statements. Realization of intangible assets, including goodwill (Notes 2.3(g), 2.4(aIII), 2.4(h) and 14) The balances intangible assets, including goodwill We confirmed our understanding and tested the are tested semiannually for impairment. These design and effectiveness of the main controls tests involve estimates and significant judgment, established, including the analysis of the critical including the identification of cash-generation judgment and assumptions used by management, units. The determination of expected cash flows which already include impacts due to the and the risk-adjusted interest rate for each cash- COVID-19 pandemic. generating unit or group of cash-generating units requires that management apply judgment and We tested the most relevant projections and estimates. assumptions for the determination of the impairment test of goodwill and intangible assets We continued focusing on this area in our audit as prepared by Management, to assess the because: (i) it involves the projection of future reasonableness of these realization estimates. results, in which using different assumptions may significantly modify the perspective of realization We believe that the assumptions that of these assets and the possible need to account management adopted to evaluate the realization for impairment, with consequent impact on the of intangible assets are appropriate and that the financial statements; and (ii) the impact disclosures in the accompanying notes are generated on the Bank and its subsidiaries’ consistent with the information obtained, current results due to aspects related to the considering the individual and consolidated COVID-19 pandemic; (iii) of the relevance of financial statements taken as a whole. these accounts in the context of the financial statements.

Itaú Unibanco Holding S.A. Why it is a key audit matter How the matter was addressed in the audit Provisions and contingent liabilities (Notes 2.3(j), 2.4 (n) and 29) The Bank and its subsidiaries have provisions and We confirmed our understanding and tested the contingent liabilities mainly arising from judicial design and the effectiveness of the main controls and administrative proceedings, inherent to the used to identify, assess, monitor, measure, record, normal course of their business, filed by third and disclose the provision for contingent parties, former employees, and public agencies, liabilities, including the totality and the integrity involving civil, labor, tax, and social security of the database. matters. We tested the models used to quantify judicial In general, the settlement of these proceedings proceedings of civil and labor natures considered takes a long time and involve not only discussions on a group basis. We were supported by our on the matter itself, but also complex specialists in the labor, legal, and fiscal areas, process-related aspects, depending on the according to the nature of each proceeding. applicable legislation. Also, we performed external confirmation In the civil and labor cases, there is the possibility procedures with both internal and external of early termination of processes through lawyers responsible for the proceedings. agreements. We considered that the criteria and assumptions During 2020, efforts continued to be made to sign adopted by Management for determining the the settlement instruments for the settlement of provision for contingent liabilities, as well as the civil lawsuits related to economic plans, including provision and contingent liabilities information the signature of an addendum to the instrument disclosed in the explanatory notes, are of agreement between the clients (represented by appropriate considering the individual and civil associations) and FEBRABAN to extend the consolidated financial statements taken as a agreement period by another 30 months. whole. Besides the subjective aspects in determining the possibility of loss attributed to each case, the evolution of case law on certain causes is not always uniform. Considering the materiality of the amounts and the uncertainties and judgments involved, as described above, in determining, recording and disclosing the required items, we continue to consider this an area of audit focus. Other matters Statement of added value The consolidated statement of added value for the year ended December 31, 2020, prepared under the responsibility of the Bank’s management and presented as supplementary information for IFRS purposes, was submitted to audit procedures performed in conjunction with the audit of the Bank’s financial statements. For the purpose of forming our opinion, we evaluated whether this statement is reconciled with the consolidated financial statements and accounting records, as applicable, and if its form and content are in accordance with the criteria defined in Technical Pronouncement CPC 09—“Statement of Added Value”. In our opinion, this statement of added value has been properly prepared, in all material respects, in accordance with the criteria established in the Technical Pronouncement and is consistent with the consolidated financial statements taken as a whole.

Itaú Unibanco Holding S.A. Other information accompanying the financial statements and the auditor’s report The Bank’s management is responsible for the other information that comprises the Management Report. Our opinion on the financial statements does not cover the Management Report, and we do not express any form of audit conclusion thereon. In connection with the audit of the consolidated financial statements, our responsibility is to read the Management Report and, in doing so, consider whether this report is materially inconsistent with the consolidated financial statements or our knowledge obtained in the audit or otherwise appears to be materially misstated. If, based on the work we have performed, we conclude that there is a material misstatement in the Management Report, we are required to report that fact. We have nothing to report in this regard. Responsibilities of management and those charged with governance for the consolidated financial statements Management is responsible for the preparation and fair presentation of the consolidated financial statements in accordance with the International Financial Reporting Standards (IFRS) issued by the International Accounting Standards Board (IASB), and for such internal control as management determines is necessary to enable the preparation of financial statements that are free from material misstatement, whether due to fraud or error. In preparing the financial statements, management is responsible for assessing the Bank’s ability to continue as a going concern, disclosing, as applicable, matters related to going concern and using the going concern basis of accounting unless management either intends to liquidate the Consolidated or to cease operations, or has no realistic alternative but to do so. Those charged with governance are responsible for overseeing the Bank’s and its subsidiaries financial reporting process. Auditor’s responsibilities for the audit of consolidated financial statements Our objectives are to obtain reasonable assurance about whether the financial statements as a whole are free from material misstatement, whether due to fraud or error, and to issue an auditor’s report that includes our opinion. Reasonable assurance is a high level of assurance but is not a guarantee that an audit conducted in accordance with Brazilian and International Standards on Auditing will always detect a material misstatement when it exists. Misstatements can arise from fraud or error and are considered material if, individually or in the aggregate, they could reasonably be expected to influence the economic decisions of users taken on the basis of these financial statements. As part of an audit in accordance with Brazilian and International Standards on Auditing, we exercise professional judgment and maintain professional skepticism throughout the audit. We also: Identify and assess the risks of material misstatement of the consolidated financial statements, whether due to fraud or error, design and perform audit procedures responsive to those risks, and obtain audit evidence that is sufficient and appropriate to provide a basis for our opinion. The risk of not detecting a material misstatement resulting from fraud is higher than for one resulting from error, as fraud may involve collusion, forgery, intentional omissions, misrepresentations, or the override of internal control. Obtain an understanding of internal control relevant to the audit in order to design audit procedures that are appropriate in the circumstances, but not for the purpose of expressing an opinion on the effectiveness of the internal control of the Bank and its subsidiaries.

Itaú Unibanco Holding S.A. Evaluate the appropriateness of accounting policies used and the reasonableness of accounting estimates and related disclosures made by management. Conclude on the appropriateness of management’s use of the going concern basis of accounting and, based on the audit evidence obtained, whether a material uncertainty exists related to events or conditions that may cast significant doubt on the Bank’s ability to continue as a going concern. If we conclude that a material uncertainty exists, we are required to draw attention in our auditor’s report to the related disclosures in the financial statements or, if such disclosures are inadequate, to modify our opinion. Our conclusions are based on the audit evidence obtained up to the date of our auditor’s report. However, future events or conditions may cause the Bank to cease to continue as a going concern. Evaluate the overall presentation, structure and content of the consolidated financial statements, including the disclosures, and whether these financial statements represent the underlying transactions and events in a manner that achieves fair presentation. Obtain sufficient appropriate audit evidence regarding the financial information of the entities or business activities within the Group to express an opinion on the consolidated financial statements. We are responsible for the direction, supervision and performance of the group audit. We remain solely responsible for our audit opinion. We communicate with those charged with governance regarding, among other matters, the planned scope and timing of the audit and significant audit findings, including any significant deficiencies in internal control that we identify during our audit. We also provide those charged with governance with a statement that we have complied with relevant ethical requirements regarding independence, and to communicate with them all relationships and other matters that may reasonably be thought to bear on our independence, and where applicable, related safeguards. From the matters communicated with those charged with governance, we determine those matters that were of most significance in the audit of the financial statements of the year ended December 31, 2020 and are therefore the key audit matters. We describe these matters in our auditor’s report unless law or regulation precludes public disclosure about the matter or when, in extremely rare circumstances, we determine that a matter should not be communicated in our report because the adverse consequences of doing so would reasonably be expected to outweigh the public interest benefits of such communication. São Paulo, February 1, 2021 PricewaterhouseCoopers Auditores Independentes CRC 2SP000160/O-5 Emerson Laerte da Silva Contador CRC 1SP171089/O-3

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MANAGEMENT REPORT 2020 Dear reader, Since March 2020, Brazil has faced an unprecedented health crisis that has affected all sectors of the economy and society. As a Brazilian bank with the majority of our operations in this country, we have been significantly affected by the economic, political and social conditions, of Brazil. Brazil’s GDP, which grew by 1.4% in 2019, is expected to decline by 4.1% at the close of 2020, affected by the coronavirus outbreak. Quarterly comparison show a decline of 1.5% and 9.6% in 1Q20 and 2Q20, respectively. In 3Q20, the fiscal response, the loosening of monetary policy and the gradual recovery of economic activity from June onward saw GDP recover by 7.7%, also in a quarterly comparison. We are forecasting GDP growth of 4.0% for 2021, even though the reduction in emergency assistance is expected to impact consumption in the first half-year; the hope is for the recovery to gain pace once vaccination begins here. In addition, the growth in private credit in this scenario of low interest rates should contribute to the expansion of the Brazilian economy. The SELIC rate stood at 2.0% in August 2020 and has remained at this level ever since. Bank loans in proportion to GDP grew to 53.1% in November 2020, in comparison with 46.4% for the same month of the previous year. Inflation reached 4.4% for the year ended December 31, against 4.3% for the year ended December 31, 2019. It is important to highlight that the measures adopted to deal with the COVID-19 crisis affected the government accounts. The twelve-month deficit in the balance of the country’s primary budget in 2020 was 8.9% of GDP in November, after deficits of 0.8% in 2019, 1.5% in 2018 and 1.7% in 2017. However, the ceiling on expenditures, notwithstanding the challenging scenario, should be met in the years ahead. Keeping the customer at the center of everything we do, we were able to reinvent ourselves without forgetting about our teams, and there is no doubt that we have reached the end of the year even stronger as an organization and even more convinced of our role in society. In 2020, we had 56,444 employees trained to work from home office, in addition to supporting our employees in the physical branches with protection and safety procedures and equipment. As a result of this effort to provide our teams with the best possible conditions, we achieved 90 points in the E-NPS (the index that measures employee satisfaction), a record milestone, in addition to having been elected by Valor Career and UOL as the best place in people management and to work, respectively. Having secured the best possible well-being for our teams, we were able to devote ourselves to supporting our customers during such a challenging period, with all-in, sustainable solutions. We continued to see growth in our digital channels in the fourth quarter of the year. Via the digital channel, we opened 514 thousand individual and 6.9 thousand business accounts, growth of 92% and 87% respectively over the same period of the previous year. During the second fortnight of March 2020 we launched the 60+ program which, among other measures, provided a grace period of 60 days on payments of delinquent loan agreements. In mid-April 2020, we rolled out a wider ranging program called Travessia (Crossing). On December 31, 2020, the balance of the portfolio of personal, very small and small company loans with flexible repayment terms stood at R$ 50.8 billion. We provided support to very small and small companies under the National Support Program for Very Small and Small Companies (Pronampe) and through the Investment Guarantee Fund (FGI BNDES), within the scope of the Emergency Program for Access to Credit intended for Very Small, Small and Middle Market Companies, self-employed truck drivers and individual entrepreneurs. Under the latter, in the fourth quarter we made available R$ 3.2 billion to over 8.6 thousand10 companies.

We are pleased to see the result of the efforts in favor of our customers, having won the Reclame Aqui Award in five categories, in addition to having reached the target we had set ourselves two years ago of increasing our NPS (the customer satisfaction index) by 10 points by 2020. In November we reached the mark of 58 points, 10 points more than in 2018, even with the challenges that we could not have foreseen. Last, but not least, we have reached 2021 with an optimistic outlook on the future, aware of the complexities that lie ahead. Our new CEO as from February 2021, Milton Maluhy, announced in December the new members of the Executive Committee, which has been configured with the main objective of getting even closer to the business while simplifying our operations and the bank’s management model, enabling greater autonomy and speed in decision making. We are addressing the customers’ demands for investment solutions against a scenario of low interest rates. We have introduced our new Itaú Personnalité investment recommendation model which, based on 12 million monthly simulations and with around 300,000 portfolio combinations for each investor profile, allows our team of specialists to test each combination in 10,000 different scenarios until the best option for each investor profile is identified. We also announced a new investment advisory model based on the agile work model. By opening this platform to products of other companies, we offer services supported by a system of algorithms for recommending investments in an unbiased manner. We will hire 1,700 specialists for this new structure, allocated to the 120 offices to be created nationwide. Besides these initiatives, we will integrate our customers’ experience with investments in the bank and in our brokerage firm, Itaú Corretora, using an ion application whose objective is to provide an intuitive, digital and integrated experience. The application, still exclusive to the bank’s customers, offers a wide variety of products of Itaú and other asset managers in the market, with graphic analysis, comparisons, recommendations and news, providing a unique experience for each profile. Private pension products now have the option of 100% international exposure. We launched the Itaú International Private Pension Portfolio, the first product in this category in the Brazilian market which can have up to 100% exposure to the market international. In line with the bank’s movement in working to democratizing investments in Brazil, this plan is accessible to all ranges of clients, with an initial investment of just R$ 1.00. We have strengthened our tradition of recognizing the value of environmental, social and governance criteria with new funds. We have Brazil’s largest private asset management company, and we continue advancing in favor of ESG (Environmental, Social and Governance) criteria with three new investment funds. These are: The Itaú International ESG Portfolio, which aims for the best combination of strategies where the focus is on assets positioned in ESG criteria; the Itaú ESG H2O Ações, whose objective is to invest in the shares of 50 global companies linked in a positive way to the water business, and Itaú ESG Energia Limpa Ações whose focus is to invest in 30 ‘clean energy’ companies involved in the biofuel, ethanol, geothermal, hydroelectric, solar and wind energy sectors. With the aim of strengthening transaction security and accelerating the delivery of financial services, we have selected AWS as our partner in our Digital Transformation process. We have chosen Amazon Web Services, Inc. (AWS) as our long-term, strategic cloud services provider. We will use the world’s leading cloud services provider to accelerate our digital transformation and to enhance the banking experience of our clients worldwide. As part of the 10-year agreement that expands our relationship with AWS, we will migrate the largest portion of our IT Infrastructure from mainframes and our data centers to the cloud. 11

To reinforce its solutions package, iti is launching its first annual charge-free credit card. In both the virtual and physical versions, this is the first solution of iti involving credit. To make access to credit more dramatic, the card will be automatically available in the iti portfolio and, in addition to its traditional functions, it can be used for functionalities within the app itself, such as payments using QR Code. Reflecting our concern about accessibility, the physical credit card will be identified in Braille. Moreover, the new card contains no type of written numbering: all data are accessed using the client’s app, increasing security and reducing the chances of fraud. Additionally, the singer and entrepreneur Anitta is the star in a series of videos demonstrating the various functionalities of iti, which won the award for the best digital onboarding among financial institutions in Brazil, in a study undertaken by consulting company idwall. In effect, this award means the best digital experience for opening accounts among Brazil’s leading 25 digital banks and portfolios. In a series of rollouts, Credicard is going beyond financial services focused solely on credit cards, with the aim of becoming a payment solutions business unit. One of the hallmarks of this new phase is the rollout of a technology platform that will enable the brand to offer a more all-in payment experience, with an account already configured for free transfers via Pix and a new card, in addition to a more extensive and accessible credit access model focused on financial inclusion and guidance. Currently undergoing tests at Credicard Beta, with the client-developer co-creation model, the new system already provides for the possibility of connecting to partners using APIs and, therefore, is ready for Open Banking. With the emphasis on creating value for our shareholders, we have taken a decision about the future of the investment in XP Inc. (“XP”). On January 31, the Extraordinary General Meeting approved the segregation of the business line of the Itaú Unibanco Conglomerate regarding its participation¹ in the capital of XP Inc. to XPart., a company to be constituted after obtaining by the controllers a favorable statement from the regulatory authority. • After the favorable opinion of the regulatory authority, there is a term of up to 120 days² for listing on B3 and for distribution of the new shares of XPart, with the cut-off date (“ex”) and procedures to be informed in due course. • By the cut-off date (close to the listing date), Itaú Unibanco shares will continue to be traded with the entitlement to receive shares of XPart. • Once the new company is listed, the shareholders will receive an equity holding in XPart of the same quantity, type and proportion as the shares they hold in Itaú Unibanco. • The shareholders will continue to retain their current equity holding in Itaú Unibanco and will also become shareholders of XPart. • The percentage of XP’s capital that will be hold by XPart represented 40.52% at 12.31.2020, due to the capitalization of XP in December. (1) Equivalent to 41.05% of the capital of XP Inc on the base date of September 30, 2020. (2) According to the Corporate Law. 12

As the largest private bank in Latin America, we have spared no effort in contributing to solving the complex problems in the Amazon region. In a partnership with Bradesco and Santander, we have released an integrated plan for the purpose of making an effective contribution to the sustainable development of the Amazon. The material includes 10 measures allocated to three fronts identified as priorities for the region: environmental conservation and development of the bioeconomy; investment in sustainable infrastructure; and guarantees of the basic rights of the population of the Amazon region. The 10 measures of the Amazon Plan are: Zero deforestation in the beef chain Promoting sustainable chains; Encourage the development of sustainable Enabling investment in basic infrastructure; transport infrastructure; Climate information for credit and investment Green financial instruments; policies; Financial guidance and inclusion; Land title regularization; Social and economic development; Driving the bioeconomy. Among our initiatives, in December we held the Conference of the Amazon whose objective was to raise relevant issues and debates on matters involving the region, as well as raising funds for projects in forest recovery and the generation of local income. The event was transmitted over 3 days and brought together well-known investors and managers of Brazilian and international funds, as well as clients of the bank as special guests. One year on, we are presenting the performance results of the first twelve months since the launch of our Positive Impact Commitments. Our Positive Impact Commitments guide the decisions we take, ensuring a much view of the risks and opportunities inherent to the business. It is they that model the products and services we offer on the premise that they generate social and environmental benefits. In 2019 we introduced 8 initial commitments: Transparency in Reports and Communication, Responsible Investment, Financial Citizenship, Financing in Sectors with a Positive Impact, Inclusion and Entrepreneurship, Responsible Management, Inclusive Management and Ethics in Relations and in Business. In 2020, we published the first report with the results of the established goals obtained so far, in addition to the inclusion of the commitment to Private Social Investment. 13

We want to foster access to and the expansion of rights, improve the quality of urban life and strengthen people’s transformative power through private social investment. We are reiterating our pact with Brazilian society through our Commitment to Private Social Investment. In the face of the covid-19 pandemic, private social investment has become even more relevant by spurring the initiatives needed to weather this difficult period. Creating the commitment to Private Social Investment means reaffirming the pact of Itaú Unibanco with Brazilian society, thereby strengthening the bonds of trust amidst uncertainty. The bank’s Private Social Investment agenda, which like its other commitments is aligned with the UN Sustainable Development Objectives, is directed toward four major spheres of operation: Education, Culture, Mobility and Longevity, areas in which Itaú has an operational track record. BRAZIL LATAM3 Total Amount (R$ millions) Number of Projects Amount (R$ millions) Number of Projects (R$ millions) Sponsorship 2020 Non-incentivated1 1,880.3 1,095 33.8 98 1,914.0 Education 270.8 605 2.9 30 273.7 Sport 0.6 3 0.0 0.0 0.6 Culture 109.3 179 3.1 36 112.3 Urban Mobility 58.8 42 18.4 4 77.2 Diversity 3.7 22 0.0 0.0 3.7 Innovation and Entrepreneuship 35.8 22 0.2 6 36.0 Local Develop. and Participation 7.3 55 6.3 19 13.6 Healthcare 1,394.0 169 2.9 3 1,396.9 Incentivated2 96.5 216 0.4 2 96.9 Culture 47.6 177 0.1 1 47.7 Sport 11.3 31 0.0 0.0 11.3 Education 11.3 34 0.3 1 11.6 Healthcare 14.9 16 0.0 0.0 14.9 Senior Citizens 11.4 18 0.0 0.0 11.4 Total 1,976.8 1,311 34.2 100 2,011.0 (1) Own funds of the bank’s companies and in-house budgets of the foundations and institutions. (2) Tax incentive resources under laws such as the Rouanet Law, Sports Incentive and so on. (3) Foreign currency amounts were converted to Brazilian Reais as at December 31, 2020 Recognition of the Investor Relations area in two categories at the Apimec Ibri Awards. We were recognized in the “Large Cap Investor Relations Best Practice and Initiative” category, while Geraldo Soares as voted “Best Investor Relations Professional” at the APIMEC Awards (Association of Capital Market Investment Analysts and Professionals) and by the IBRI (the Brazilian Institute of Investor Relations). 14

Creating value is to obtain financial results that exceed the cost of capital to remunerate our shareholders and other stakeholders through ethical and responsible relations based on trust and transparency and focused on the sustainability of the business. We present below the key indicators comprising our results: In R$ billion 2020 2019 Variation Income Information Operating Revenues 1 117.9 119.6 -1.4% Net Interest Income ² 67.8 71.8 -5.7% Banking Services Fees and Insurance ³ 43.0 43.6 -1.2% Expected Loss from Financial Assets and Claims (26.0) (18.6) 39.9% General and Administrative Expenses (64.2) (61.0) 5.2% Net Income 15.1 27.8 -45.8% Net Income Attributable to Controlling Shareholders 18.9 27.1 -30.3% Recurring Managerial Return on Average Equity—Annualized 4 14.1% 20.9% -680 bps 2020 2019 Variation Balance Sheet Information Total Assets 2,019 1,637 23.3% Total Loan Portfolio5 873.1 725.3 20.4% Tier I Capital 13.2% 14.4% -120 bps 2020 2019 Variation Shares Weighted Average Number of Outstanding Shares – in millions 9,760 9,740 -3.7% Net Income Attributable to Controlling Shareholders per share—R$ 1.94 2.73 -30.2% Dividends and Net Interest on Own Capital6 4.50 18.78 -76.0% 2020 2019 Variation Others Branches 4,337 4,504 -3.7% Physical and Client Service Branches (CSBs) 4,141 4,308 -3.9% Digital Branches 196 196 0.0% Employees (in thousands) 96.5 94.9 1.7% Brazil 83.9 81.7 2.7% Abroad 12.6 13.2 -4.3% (1) Operating Revenues are the sum of (i) Interest Income and similar income of financial assets at amortized cost and at fair value through other comprehensive income; (ii) Interest, similar income and dividend of financial assets at fair value through profit or loss; (iii ) Interest and Similar Expenses, (iv) Adjustments to Fair Value of Financial Assets and Liabilities; (v) Foreign exchange results and exchange variations in foreign transactions (vi) Revenues from banking services (vii) Income from insurance and private pension operations before claim and selling expenses (viii) Other income. For better comparability, the adjustment of the hedge tax effects on foreign investments was applied; (2) The sum of (i) Revenue from Interest and Earnings from Financial Assets at Amortized Cost and Fair Value through Other Comprehensive Income, (ii) Revenue from Interest, Earnings and Dividends on Financial Assets at Fair Value through Income, (iii) Interest and Similar Expenses, (iv) Adjustment to Fair Value of Financial Assets and Liabilities and (v) Result from Exchange Operations and Exchange Rate Variation on Overseas Transactions; (3) The sum on the Revenues from Services and Revenues from Insurance, Pension Plans and Savings Bonds, before Claims and Sales Expenses, net of reinsurance. For better comparability, the adjustment of the hedge tax effects on foreign investments was applied; (4)The return is calculated by dividing the recurrent Net Income by the Average Shareholders’ Equity. The quotient was multiplied by the number of periods in the year to derive the annualized rate. The calculation of the returns were adjusted for the amounts of proposed dividends after the closure dates of the balance sheets not yet approved in ordinary meetings of shareholders or at meetings of the Board of Directors.; (5) Portfolio of Loans with Financial Guarantees Provided and Private Securities; (6) Amounts paid/provisioned, declared and highlighted in the shareholders’ equity. 15

Results & Capital Management The percentages of increase or decrease in this section refer to the comparison between 2020 in relation to 2019, unless otherwise indicated. In 2020, our Net Income Attributable to Controlling Shareholders reached R$18.9 billion, down by 30.3% compared to the same period in the previous year, mainly due to lower operating revenues and increase in expected loss from financial assets and claims. The managerial return on annualized average equity was 14.1%. The change in the macroeconomic scenario as of the second half of March 2020, drove an increase of 39.9% in our expected losses on financial assets and claims, which reached R$26,0 billions. This change, captured by our expected loss provisioning model, generated a higher allowance for loan losses, in our operations in Brazil, as well as Latin America. We highlight the 20.4% growth of total credit portfolio. The growth of the portfolios in the main segments was: • 6.2% for private individuals; • 26.3% in very small, small and middle market companies in Brazil; • 22.2% in large companies in Brazil; • 30.7% in our Latin America operations, affected primarily by exchange rate variation; In comparison with 2019, there was growth of 31.9% in credit origination in Brazil, namely: • 14.1% for private individuals; • 24.0% for very small, small and middle market companies; and • 51.7% for large companies. Portfolio growth notwithstanding, we suffered a reduction of 5.7% in the net interest income on account of the lower spreads on credit products, changes in the regulations on interest rates on overdraft accounts, and the adverse impact of the reduction in the interest rate on our own working capital and liabilities margin. We also had an increase in our financial expenses, mainly due to exchange rate variation. Revenues from services and insurance suffered a reduction of 1.2% in the year. This slight reduction is due to the lower revenue from credit and debit cards, which includes revenue from acquiring services, rmainly in the first semester of the year. It is worth mentioning that in the fourth quarter of 2020 the volume of credit and debit transactions increased by 9.0% over the fourth quarter of 2019 and 17.9% over the third quarter of 2020. This decrease in revenue from acquiring services was partially offset by a 15.2% increase in income from advisory services and brokerage, as a result of greater activity in the capital market. General and administrative expenses increased by 5.2% in 2020 compared to 2019, mainly due to the increase in extraordinary expenses, such as the impairment of goodwill and intangible assets at Itaú Corpbanca, the donation to combat COVID-19 made to the alliance “Todos pela Saúde.” In the second half of 2019, we also had the Voluntary Termination Program. Disregarding the extraordinay events mentioned above, our general and administrative expenses decreased 2.3% in 2020 compared to 2019. This reduction is related to our strategic cost management and our continuous investment in technology. There was also a decrease in data processing and telecommunications, installations, materials and credit cards selling expenses, especially due to lower economic activity resulting from the COVID-19 pandemic. Another highlight in 2020 was the increase in funding: • 77.2% in time deposits; • 63.8% in demand deposits; and • 24.2% in savings deposits. 16

These growth figures reflect the positive flow of resources from the second fortnight of March 2020 onward. The Tier 1 Capital Ratio measures the ratio of the bank’s capital to the risk level of its assets. Maintaining adequate levels aims to protect the institution in case of severe events. By managing our capital we aim to optimize how we invest our shareholders’ resources while ensuring the bank’s solidness. We present below the main events that affected our ratio in the fourth quarter of 2020: Tier I Capital Ratio Commom Equity Tier I (CET I) Additional Tier 1 Capital (AT1) On December 31, 2020, our Tier 1 Capital Ratio stood at 13.2%, 495 bps above the minimum regulatory level with capital buffers (8.25%). Our Tier 1 Capital consists of 11.5% of Core Capital and 1.7% of Additional Tier 1 Capital. The following graph shows the financial volume traded daily with our shares, which have a relevant participation in market indices in Brazil and abroad Our shares continue to enjoy high liquidity in trading, both in Brazil and in the United States, with an increase of 53% in the average daily trading volume since 2018 Average Daily Trading Volume of the Shares of Itaú Unibanco (R$ millions) +53% 1,912 1,253 1,388 1,053 B3 (ON+PN) 744 653 NYSE (ADR) 600 644 859 2018 2019 2020 17

Additionally, our shares end the period quoted at R$ 31.63 (ITUB4 – preferred shares) e R$ 27.93 (ITUB3 – acommon shares). We present below the evolution of R$ 100 invested on the date prior to the merger in november of 2008. 560 328 319 293 246 nov-08 jun-09 feb-10 oct-10 jun-11 feb-12 oct-12 jun-13 feb-14 oct-14 nov-15 jul-16 jun-17 jan-18 aug-18 jul-19 mar-20 dec-20 ITUB4 dividend-adjusted ITUB4 without adjustment for dividends CDI Rate Ibovespa US Dollar Subsequent event In January 2021, Itaú approached the international capital markets to raise funds through sustainable debt instrument. We raised U$ 500 million whose proceeds will be allocated to finance or refinance eligible green and social projects according to the criteria defined by the Framework for Sustainable Finance. The securities carry a term of 10 years and 3 months, remunerating investors at 3.95%. This was the first issuance of Tier 2 capital by a financial institution to finance or refinance green and social projects in Latin America. The proceeds may be allocated to eight eligible categories, namely: renewable energy and energy efficiency, sustainable transport, sustainable water and waste management, pollution prevention and control, sustainable management of natural resources and land use, green buildings, access to essential services and inclusive finance. The issuance of these debt securities is yet another step by the bank to demonstrate how sustainability has been incorporated into the business of Itaú Unibanco. Acknowledgements Our sincere thanks to our employees who, in the face of the current crisis, have answered the call and committed themselves to keeping our operations functioning, enabling us to continue producing solid results and our thanks to our customers and shareholders for their understanding, interest and trust, which spur us on to always do our best. (Approved at the Meeting of the Board of Directors on February 1, 2021) 18

Independent Auditor – CVM Instruction No. 381 Procedures Adopted by the Company Our operating policy, including subsidiaries, when contracting non-external audit-related services from our independent auditors, is based on applicable regulations and internationally accepted principles that protect the independence of the auditors. These principles state that: (a) the auditors must not audit their own work, (b) the auditors must not hold managerial positions at their clients, and (c) the auditors must not promote their clients’ interests. In the period from January to December 2020, we hired from the independent auditors the amount of R$ 72,156 thousand, which R$ 66,631 thousand are non-external audit-related services. Bellow we list the agreements dates and the nature of the services provided, all of which did not exceed one year: • Audit Related Services: January 23 and 27, February 06, March 16, June 19, July 14, August 06 and 18, October 19 and 30, December 15 and 22 – Independent assurance about: subsidiary system implementation aspects; internal controls, including certain services provided to customers; sustainability report, MD&A, Integrated Report and Consolidated Annual Report; certain agreements signed with regulatory authorities and compliance with financial covenants. Appraisal reports at book value, and previously agreed procedures of acquired companies balance sheets and about profit share calculation. – R$ 4,896 thousand (7.35% of the external audit fees). • Tax Servicers: January 23, February 06 and 12 – review of the calculations and tax settlement and compliance with tax regulations – R$ 541 thousand (0.81% of the external audit fees). • Other Services: May 27 and December 21—use of technical materials and an independent review of the financial and prudential information reporting process. – R$ 88 thousand (0.13% of the external audit fees). Justification of the Independent Auditors – PricewaterhouseCoopers The non-external audit-related services described above does not affect either the independence or the objectivity in conducting external audit examinations at Itaú Unibanco and its subsidiaries. The policy for providing Itaú Unibanco with non-external audit-related services is based on principles that protect the independent auditor’s independence, all of which were observed in providing that services, including their approval by the Audit Committee. Accounting Practices Adapted in Brazil (BRGAAP) We are disclosing the full accounting statements in accordance with the accounting practices adopted in Brazil (BRGAAP) on the same date as this publication, as per Official Circular CVM/SEP/01/13. The Management’s Report and the Full Accounting Statements of Itaú Holding S.A. and of its subsidiaries for the period January to December 2020 abide by the rules established by the National Monetary Council (CMN), in accordance with the international financing reporting standards approved by the International Accounting Standards Board (IASB). As of January 1, 2018, the new accounting standard, IFRS 9, on financial instruments came into force. The standard shows significant modifications to classification and measurement, impairment and booking of hedges. One of the key points refers to how to deal with losses incurred. With the advent of IFRS 9, they will be treated as expected, instead of incurred, as previously. The information in both the Management Report and the Complete Financial Statements of Itaú Unibanco Holding S.A. presented in this material are available on the Itaú Unibanco Investor Relations (IR) website.at: www.itau.com.br/relacoes-com-investidores> Menu > Results Center > Results. 19

ITAÚ UNIBANCO HOLDING S.A. Consolidated Balance Sheet (In millions of Reais) Assets Note 12/31/2020 12/31/2019 Cash46,22430,367 Financial Assets 1,851,322 1,501,481 At Amortized Cost 1,275,799 1,101,892 Compulsory deposits in the Central Bank of Brazil90,05991,248 Interbank deposits 455,68534,583 Securities purchased under agreements to resell 4 239,943 198,428 Securities 9 129,804 133,119 Loan and lease operations 10 714,104 585,791 Other financial assets 18a 93,255 94,752 (-) Provision for Expected Loss 4, 9 and 10 (47,051)(36,029) At Fair Value Through Other Comprehensive Income 109,942 76,660 Securities 8 109,942 76,660 At Fair Value Through Profit or Loss 465,581 322,929 Securities 5 389,071 281,075 Derivatives 6 and 776,504 41,854 Other financial assets 18a 6 -Investments in associates and joint ventures 1115,57015,097 Fixed assets, net 13 6,937 7,166 Goodwill and Intangible assets, net 14 17,330 19,719 Tax assets66,09548,960 Income tax and social contribution—current3,547 1,644 Income tax and social contribution—deferred 24b56,58338,914 Other 5,965 8,402 Other assets 18a15,77314,691 Total assets 2,019,251 1,637,481 The accompanying notes are an integral part of these consolidated financial statements. Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 20

ITAÚ UNIBANCO HOLDING S.A. Consolidated Balance Sheet (In millions of Reais) Liabilities and stockholders’ equity Note 12/31/2020 12/31/2019 Financial Liabilities 1,579,686 1,211,999 At Amortized Cost 1,495,641 1,159,830 Deposits 15 809,010 507,060 Securities sold under repurchase agreements 17a 273,364 256,583 Interbank market funds 17b 156,035 174,862 Institutional market funds 17c 138,308 104,244 Other financial liabilities 18b 118,924 117,081 At Fair Value Through Profit or Loss79,653 48,029 Derivatives 6 and 7 79,505 47,828 Structured notes 16 143 201 Other financial liabilities 18b5- Provision for Expected Loss 10 4,392 4,140 Loan commitments 3,485 3,303 Financial guarantees 907 837 Provision for insurance and private pensions 27c 221,000 218,334 Provisions 2919,81921,454 Tax liabilities 24c 5,710 7,891 Income tax and social contribution—current2,8783,997 Income tax and social contribution—deferred 24b 421 1,058 Other2,4112,836 Other liabilities 18b 38,511 28,338 Total liabilities 1,864,726 1,488,016 Capital 19a97,14897,148 Treasury shares 19a(907) (1,274) Additional paid-in capital 19c2,5192,175 Appropriated reserves 19c17,228 12,948 Unappropriated reserves 19c 29,926 29,878 Other comprehensive income(2,921)(3,950) Total stockholders’ equity attributed to the owners of the parent company 142,993 136,925 Non-controlling interests 19d 11,532 12,540 Total stockholders’ equity 154,525 149,465 Total liabilities and stockholders’ equity 2,019,251 1,637,481 The accompanying notes are an integral part of these consolidated financial statements. Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 21

ITAÚ UNIBANCO HOLDING S.A. Consolidated Statement of Income Periods ended (In millions of Reais, except for number of shares and earnings per share information) 01/01 to 01/01 to 01/01 to Note 12/31/2020 12/31/2019 12/31/2018 Operating Revenues 100,199 117,079 104,200 Interest and similar income of financial assets at amortized cost and at fair value through 21a113,262117,523110,324 other comprehensive income Interest, similar income and dividend of financial assets at fair value through profit or loss 15,71622,76022,853 Interest and similar expenses 21b (73,558) (75,958) (70,612) Adjustments to Fair Value of Financial Assets and Liabilities 21c (8,056) 4,098 (4,834) Foreign exchange results and exchange variations in foreign transactions2,6899272,974 Commissions and Banking Fees 2238,55739,03236,809 Income from insurance and private pension operations before claim and selling 4,4884,553 3,961 expenses Revenues from insurance premiuns and private pensions14,80419,62424,097 Change in provision for insurance and private pension (10,316) (15,071) (20,136) Other income 37,1014,1442,725 Expected Loss from Financial Assets and Claims(25,980)(18,567)(10,182) Expected Loss with Loan and Lease Operations 10c (24,452) (18,298) (10,587) Expected Loss with Other Financial Asset, net (174) 1,0261,633 (Expenses) / Recovery of claims (1,354) (1,295) (1,228) Operating Revenues Net of Expected Losses from Financial Assets and Claims 74,219 98,512 94,018 Other operating income (expenses)(68,989)(67,269)(63,410) General and administrative expenses 23 (64,207) (61,012) (57,538) Tax expenses (6,181) (7,572) (6,619) Share of profit or (loss) in associates and joint ventures 111,3991,315747 Income / (loss) before income tax and social contribution5,23031,24330,608 Current income tax and social contribution 24a (8,655) (9,092) (2,564) Deferred income tax and social contribution 24a18,4895,662 (2,405) Net income / (loss)15,06427,81325,639 Net income attributable to owners of the parent company 2518,89627,11324,907 Net income / (loss) attributable to non-controlling interests 19d (3,832) 700732 Earnings per share—basic 25 Common1.942.78 2.56 Preferred1.942.78 2.56 Earnings per share—diluted 25 Common1.932.77 2.55 Preferred1.932.77 2.55 Weighted average number of outstanding shares—basic 25 Common 4,958,290,359 4,958,290,359 4,958,290,359 Preferred 4,801,324,161 4,781,855,588 4,759,872,085 Weighted average number of outstanding shares—diluted 25 Common 4,958,290,359 4,958,290,359 4,958,290,359 Preferred 4,843,233,835 4,826,925,107 4,815,473,777 The accompanying notes are an integral part of these consolidated financial statements. Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 22

ITAÚ UNIBANCO HOLDING S.A. Consolidated Statement of Comprehensive Income Periods ended (In millions of Reais) 01/01 to 01/01 to 01/01 to Note 12/31/2020 12/31/2019 12/31/2018 Net income 15,064 27,813 25,639 Financial assets at fair value through other comprehensive income 148 1,810 (166) Change in fair value 1,214 2,883 (576) Tax effect (457) (696) 270 (Gains) / losses transferred to income statement 21c (1,107) (628) 254 Tax effect 498 251 (114) Hedge (3,557) (16)(1,135) Cash flow hedge 7 499 (56)(81) Change in fair value 947 (191)(256) Tax effect (448) 135 175 Hedge of net investment in foreign operation 7 (4,056) 40 (1,054) Change in fair value (7,616)83 (1,793) Tax effect 3,560 (43) 739 Remeasurements of liabilities for post-employment benefits (*) (192) (350)(164) Remeasurements 26 (349) (648)(267) Tax effect 157 298 103 Foreign exchange variation in foreign investments 4,630 (1,582) 1,139 Total other comprehensive income 1,029 (138)(326) Total comprehensive income 16,093 27,675 25,313 Comprehensive income attributable to non-controlling interests (3,832) 700 732 Comprehensive income attributable to the owners of the parent company 19,925 26,975 24,581 (*) Amounts that will not be subsequently reclassified to income. The accompanying notes are an integral part of these consolidated financial statements. Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 23

ITAÚ UNIBANCO HOLDING S.A. Consolidated Statement of Changes in Stockholders’ Equity (Notes 19 and 20) Periods ended December 31, 2020, 2019 and 2018 (In millions of Reais) Attributed to owners of the parent company Other comprehensive income Total Total stockholders’ stockholders’ Additional Financial Assets Treasury Appropriated Unappropriated Retained Remeasurements Conversion equity – owners equity – non- Total at Fair Value Gains and Capital paid-in of liabilities of post- adjustments of of the parent controlling shares reserves reserves earnings Through Other losses – capital Comprehensive employment foreign (2) company interests hedge (1) benefits investments Income Balance at 01/01/2018 97,148 (2,743) 1,930 12,499 26,030—(944) (825)2,667 (4,384) 131,378 12,978 144,356 Transactions with owners—923 190 (534) — — — 579 131 710 Cancellation of treasury shares – Meeting of the Board of Directors 02/22/2018—534—(534) — — — ——Acquisition of treasury shares—(510) — — — — (510)—(510) Result of delivery of treasury shares—899 422 — — ——1,321—1,321 Recognition of share-based payment plans — (232) — — ——(232)—(232) (Increase) / Reduction of interest of controlling stockholders (Note 2.4a I and 3) — — — — ——131 131 Dividends ——7,394—(12,650) — — (5,256) (157) (5,413) Interest on capital ——7,285—(8,198) — — (913)—(913) Dividends / Interest on capital paid in 2018 – declared after 12/31/2017 ——(13,673) — — — (13,673)—(13,673) Unclaimed dividends — ——4 — — 4—4 Corporate reorganizations (Note 2.4 a III) ——(592) — — — (592)—(592) Other — — 674 — ——674—674 Total comprehensive income - — — 24,907 (166) (164) 1,139 (1,135) 24,581 732 25,313 Net income — ——24,907 — — 24,907 732 25,639 Other comprehensive income for the period — — — (166) (164) 1,139 (1,135) (326)—(326) Appropriations: Legal reserve ——1,097—(1,097) — — ——Statutory reserve ——4 2,962 (2,966) — — ——Balance at 12/31/2018 97,148 (1,820) 2,120 13,480 29,666—(1,110) (989) 3,806 (5,519) 136,782 13,684 150,466 Change in the period-923190 981 3,636-(166)(164)1,139 (1,135)5,404 706 6,110 Balance at 01/01/2019 97,148 (1,820) 2,120 13,480 29,666—(1,110) (989) 3,806 (5,519) 136,782 13,684 150,466 Transactions with owners—546 55 — — ——601—601 Result of delivery of treasury shares—546 351 — — ——897—897 Recognition of share-based payment plans — (296) — — ——(296)—(296) (Increase) / Reduction of interest of controlling stockholders (Note 2.4a I and 3) — — — — ——(1,567) (1,567) Dividends ——4,709—(14,129) — — (9,420) (277) (9,697) Interest on capital ——5,102—(5,468) — — (366)—(366) Dividends / Interest on capital paid in 2019 – declared after 12/31/2018 ——(17,500) — — — (17,500)—(17,500) Unclaimed dividends and Interest on capital — ——42 — — 42—42 Other (3) — — (189) — ——(189)—(189) Total comprehensive income — ——27,113 1,810 (350) (1,582) (16) 26,975 700 27,675 Net income — ——27,113 — — 27,113 700 27,813 Other comprehensive income for the period — — — 1,810 (350) (1,582) (16) (138)—(138) Appropriations: Legal reserve ——1,336—(1,336) — — ——Statutory reserve ——5,821 401 (6,222) — — ——Balance at 12/31/2019 97,148 (1,274) 2,175 12,948 29,878—700 (1,339) 2,224 (5,535) 136,925 12,540 149,465 Change in the period—546 55 (532)212-1,810(350)(1,582)(16)143(1,144) (1,001) Balance at 01/01/2020 97,148 (1,274) 2,175 12,948 29,878—700 (1,339) 2,224 (5,535) 136,925 12,540 149,465 Transactions with owners—367 344 — — ——711 3,329 4,040 Result of delivery of treasury shares—367 200 — — ——567—567 Recognition of share-based payment plans — 144 — — ——144—144 (Increase) / Reduction of interest of controlling stockholders (Note 2.4a I and 3) — — — — ——3,329 3,329 Dividends — ——(1,756) — — (1,756) (505) (2,261) Interest on capital — ——(3,232) — — (3,232)—(3,232) Dividends / Interest on capital paid in 2020 – declared after 12/31/2019 ——(9,811) — — — (9,811)—(9,811) Unclaimed dividends and Interest on capital — ——118 — — 118—118 Other (3) — — 113 — ——113—113 Total comprehensive income — — 18,896 148 (192) 4,630 (3,557) 19,925 (3,832) 16,093 Net income — ——18,896 — — 18,896 (3,832) 15,064 Other comprehensive income for the period — — — 148 (192) 4,630 (3,557) 1,029—1,029 Appropriations: Legal reserve ——948—(948) — — ——Statutory reserve ——13,143 (65) (13,078) — — ——Balance at 12/31/2020 97,148 (907) 2,519 17,228 29,926—848 (1,531) 6,854 (9,092) 142,993 11,532 154,525 Change in the period—367 344 4,280 48—148 (192) 4,630 (3,557) 6,068 (1,008) 5,060 (1) Includes the share in other comprehensive income of investments in associates and joint ventures related to financial assets at fair value through other comprehensive income. (2) Includes cash flow hedge and hedge of net investment in foreign operation. (3) Includes Argentina´s hyperinflation adjustment. The accompanying notes are an integral part of these consolidated financial statements. Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 24

ITAÚ UNIBANCO HOLDING S.A. Consolidated Statement of Cash Flows (In millions of Reais) 01/01 to 01/01 to 01/01 to Note 12/31/2020 12/31/2019 12/31/2018 Adjusted net income 60,953 61,134 62,855 Net income 15,064 27,813 25,639 Adjustments to net income: 45,889 33,321 37,216 Share-based payment 217 (141) (98) Adjustments to fair value of financial assets through Profit or Loss and Derivatives 739 310 551 Effects of changes in exchange rates on cash and cash equivalents 11,677 (54) (990) Expected Loss from Financial Assets and Claims 25,980 18,567 10,182 Income from interest and foreign exchange variation from operations with subordinated debt 20,774 4,433 8,759 Provision for insurance and private pension 10,316 15,071 20,136 Depreciation and amortization 13 and 14 3,729 3,561 3,567 Expense from update / charges on the provision for civil, labor, tax and legal obligations 893 1,925 1,037 Provision for civil, labor, tax and legal obligations 3,602 5,132 2,465 Revenue from update / charges on deposits in guarantee (344) (519) (199) Deferred taxes (excluding hedge tax effects) 24b (239) 2,499 10,287 Income from share in the net income of associates and joint ventures and other investments (1,399) (1,315) (747) Income from Financial assets—At fair value through other comprehensive income 21c (1,107) (628) 254 Income from interest and foreign exchange variation of financial assets at fair value through other comprehensive income (21,057) (8,420) (12,808) Income from Interest and foreign exchange variation of financial assets at amortized cost (8,309) (3,332) (4,353) (Gain) loss on sale of investments and fixed assets (4,165) (168) (297) Other 23 4,582 (3,600) (530) Change in assets and liabilities (1,462) (25,974) (33,132) (Increase) / decrease in assets (50,165) (123,522) Interbank deposits (21,775) (6,897) (9,404) Securities purchased under agreements to resell (21,639) 62,487 (29,561) Compulsory deposits with the Central Bank of Brazil 1,189 2,900 4,689 Loan operations (141,951) (63,999) (51,919) Derivatives (assets / liabilities) (3,012) 1,918 217 Financial assets designated at fair value through profit or loss (108,696) (18,202) (13,105) Other financial assets 1,841 (19,143) (15,323) Other tax assets 534 3 (1,669) Other assets (18,008) (9,232) (7,447) (Decrease) / increase in liabilities 24,191 90,390 Deposits 301,950 43,636 60,486 Deposits received under securities repurchase agreements 16,781 (73,654) 17,603 Funds from interbank markets (18,827) 40,192 10,083 Funds from institutional markets 18,611 121 (1,125) Other financial liabilities 1,843 19,652 11,486 Financial liabilities at fair value throught profit or loss (60) 9 (273) Provision for insurance and private pension (9,004) 781 (1,409) Provisions (3,550) 673 (495) Tax liabilities (1,910) (3,526) (1,739) Other liabilities 10,048 2,568 (348) Payment of income tax and social contribution (5,827) (6,261) (3,879) Net cash from / (used in) operating activities 59,491 35,160 29,723 Dividends / Interest on capital received from investments in associates and joint ventures 487 838 671 Cash from the sale of financial assets—At fair value through other comprehensive income 38,738 9,074 16,622 Cash upon sale of investments in associates and joint ventures 4,982 68 266 Cash upon sale of fixed assets 13 331 175 215 Mutual rescission of intangible assets agreements 309 64 35 (Purchase) of financial assets at fair value through other comprehensive income (50,598) (24,820) (591) (Purchase) / redemptions of financial assets at amortized cost 11,863 (19,359) 5,479 (Purchase) of investments in associates and joint ventures (52) (387) (6,718) (Purchase) of fixed assets 13 (1,716) (1,621) (1,483) (Purchase) of intangible assets 14 (3,591) (2,691) (1,381) Net cash from / (used in) investment activities 753 (38,659) 13,115 Funding from institutional markets 5,260 8,548 2,906 Redemptions in institutional markets (10,581) (2,833) (15,048) Change in non-controlling interests stockholders 3,330 (1,617) 128 Result of delivery of treasury shares 494 742 1,187 Purchase of treasury shares — (510) Dividends and interest on capital paid to non-controlling interests (506) (227) (154) Dividends and interest on capital paid (11,552) (25,915) (20,093) Net cash from / (used in) financing activities (13,555) (21,302) (31,584) Net increase / (decrease) in cash and cash equivalents 2.4c 46,689 (24,801) 11,254 Cash and cash equivalents at the beginning of the period 70,811 95,558 83,314 Effects of changes in exchange rates on cash and cash equivalents (11,677) 54 990 Cash and cash equivalents at the end of the period 105,823 70,811 95,558 Cash 46,224 30,367 37,159 Interbank deposits 3,888 4,561 3,295 Securities purchased under agreements to resell—Collateral held 55,711 35,883 55,104 Additional information on cash flow (Mainly Operating activities) Interest received 121,558 134,225 122,405 Interest paid 77,011 77,315 84,668 Non-cash transactions Loans transferred to assets held for sale — -Dividends and interest on capital declared and not yet paid 3,178 838 515 The accompanying notes are an integral part of these consolidated financial statements. Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 25

ITAÚ UNIBANCO HOLDING S.A. Consolidated Statement of Added Value (In millions of Reais) 01/01 to 01/01 to 01/01 to 12/31/2020 12/31/2019 12/31/2018 Income 166,832 178,265 173,870 Interest, similar income and Dividends 141,312 147,808 139,329 Commissions and Banking Fees 38,557 39,032 36,809 Income from insurance and private pension operations before claim 4,488 4,553 3,961 Expected Loss with Other Financial Assets (24,626) (17,272) (8,954) Other 7,101 4,144 2,725 Expenses (89,421) (87,839) (79,454) Interest and similar income (73,558) (75,958) (70,612) Other (15,863) (11,881) (8,842) Inputs purchased from third parties (19,219) (17,092) (20,180) Materials, energy and others (321) (330) (339) Third party services (5,148) (4,571) (4,482) Other (13,750) (12,191) (15,359) Data processing and telecommunications (3,983) (4,278) (4,273) Advertising, promotions and publication (1,095) (1,325) (1,419) Installations (1,748) (1,779) (1,740) Transportation (347) (364) (350) Security (730) (744) (754) Travel expenses (84) (240) (232) Other (5,763) (3,461) (6,591) Gross added value 58,192 73,334 74,236 Depreciation and amortization (5,064) (4,630) (3,332) Net added value produced by the company 53,128 68,704 70,904 Added value received through transfer—Results of equity method 1,399 1,315 747 Total added value to be distributed 54,527 70,019 71,651 Distribution of added value 54,527 70,019 71,651 Personnel 22,567 25,960 22,275 Direct compensation 17,349 20,456 17,125 Benefits 4,406 4,276 4,243 FGTS – government severance pay fund 812 1,228 907 Taxes, fees and contributions 16,639 15,957 22,171 Federal 15,085 14,383 20,734 Municipal 1,554 1,574 1,437 Return on third parties’ capital—Rent 257 289 1,566 Other 257 289 1,566 Return on capital 15,064 27,813 25,639 Dividends and interest on capital 4,988 19,597 20,848 Retained earnings / (loss) attributable to controlling shareholders 13,908 7,516 4,059 Retained earnings / (loss) attributable to non-controlling shareholders (3,832) 700 732 The accompanying notes are an integral part of these financial statements. Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 26

ITAÚ UNIBANCO HOLDING S.A. Notes to the Consolidated Financial Statements At 12/31/2020 and 12/31/2019 for balance sheet accounts and From 01/01 to 12/31 of 2020, 2019 and 2018 for income statement accounts (In millions of Reais, except information per share) Note 1—Overview Itaú Unibanco Holding S.A. (ITAÚ UNIBANCO HOLDING) is a publicly-held company, organized and existing under the laws of Brazil. The head office is located at Praça Alfredo Egydio de Souza Aranha, n° 100, in the city of São Paulo, state of São Paulo, Brazil. ITAÚ UNIBANCO HOLDING has a presence in 18 countries and territories and offers a wide variety of financial products and services to personal and corporate customers in Brazil and abroad, not necessarily related to Brazil, through its branches, subsidiaries and international affiliates. It offers a full range of banking services, through its different portfolios: commercial banking; investment banking; real estate lending; loans, financing and investment; leasing and foreign exchange business. Its operations are divided into three segments: Retail Banking, Wholesale Banking, and Activities with the Market + Corporation. Further detailed segment information is presented in Note 30. ITAÚ UNIBANCO HOLDING is a financial holding company controlled by Itaú Unibanco Participações S.A. (“IUPAR”), a holding company which owns 51.71% of our common shares, and which is jointly controlled by (i) Itaúsa S.A. (“ITAÚSA”), a holding company controlled by members of the Egydio de Souza Aranha family, and (ii) Companhia E. Johnston de Participações (“E. JOHNSTON”), a holding company controlled by the Moreira Salles family. Itaúsa also directly holds 39.21% of ITAÚ UNIBANCO HOLDING’s common shares. These consolidated financial statements were approved by the Board of Directors on February 01, 2021. Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 27

Note 2 – Significant accounting policies 2.1. Basis of preparation The Consolidated Financial Statements of ITAÚ UNIBANCO HOLDING were prepared in accordance with the requirements and guidelines of the National Monetary Council (CMN), which require that as from December 31, 2010 annual Consolidated Financial Statements are prepared in accordance with the International Financial Reporting Standards (IFRS), issued by the International Accounting Standards Board (IASB). In the preparation of these Consolidated Financial Statements, ITAÚ UNIBANCO HOLDING adopted the criteria for recognition, measurement and disclosure established in the IFRS and in the interpretations of the International Financial Reporting Interpretation Committee (IFRIC). The presentation of the Statements of Value Added is required by the Brazilian corporate legislation and by the accounting practices adopted in Brazil applicable to publicly-held companies. This Statement was prepared in accordance with the criteria established by Technical Pronouncement CPC 09 – Statement of Value Added; however, the IFRS do not require the presentation of said statement. As a consequence, under IFRS, this statement is presented as supplementary information, without prejudice to the set of Financial Statements. Management believes that the information included in these Consolidated Financial Statements is relevant and a faithful representation of the information used in the management of the ITAÚ UNIBANCO HOLDING. 2.2. New accounting standards changes and interpretations of existing standards a) Accounting standards applicable for period ended December 31, 2020 · Amendment in Conceptual Framework – The main changes refer to: definitions of assets and liabilities, recognition criteria, derecognition, measurement, presentation and disclosure for equity and results elements. These changes are effective for the years started on January 1st, 2020 and there are no impacts on the Consolidated Financial Statements of ITAÚ UNIBANCO HOLDING. · Interest Rate Benchmark Reform (IBOR Reform) Phase I—Amendments to IFRS 9 – Financial Instruments, IAS 39 – Financial Instruments: Recognition and Measurement and IFRS 7 – Financial Instruments: Disclosures – Due to the changes in the interest rates used as market references – IBOR (Interbank Offered Rate), that will be terminated in future periods, there may be uncertainties in the evaluation of hedge accounting structures. Regulatory changes aim at minimizing possible impacts on these structures in the current scenario of prereplacement of rates. The regulatory exemption setting forth that these rates will not be replaced during the period of uncertainty in the analysis of hedge accounting relationships will be applied. These changes are effective for the years beginning January 1st, 2020 and they will be applied until the effective replacement of IBORs occurs or until the hedge accounting relationships are discontinued. No significant impacts have been identified in the hedge accounting structures for the Consolidated Financial Statements of ITAÚ UNIBANCO HOLDING, in the prereplacement period of IBORs. ITAÚ UNIBANCO HOLDING is exposed mainly to Libor and Euribor rates in hedge accounting structures. Since 2018, ITAÚ UNIBANCO HOLDING brings together working groups to follow the progress of discussions in the international market about the replacement of IBORs. For standardized agreements, ITAÚ UNIBANCO HOLDING will assume the updates of rates made by the respective clearings and the International Swaps and Derivatives Association—ISDA). For the other agreements, whenever possible, they will be negotiated and adjusted gradually until the end of 2021, date on which the market expects the end of disclosures of IBORs. · Amendments to IFRS 16 – Leases: Practical expedient that enables lessees not to characterize the lease concessions motivated by the COVID-19 pandemic as an agreement modification. This standard is effective for the years beginning on June 1st, 2020, and earlier application is permitted. ITAÚ UNIBANCO HOLDING opted for not using the exception arising from this standard, and, therefore, there were no impacts on the Consolidated Financial Statements. Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 28

b) Accounting standards recently issued and applicable in future periods · Interest Rate Benchmark Reform (IBOR Reform) Phase II—Amendments to IFRS 4 – Insurance Contracts, IFRS7 – Financial Instruments: Disclosures, IFRS 9 – Financial Instruments, IFRS 16 – Leases and IAS 39 – Financial Instruments: Recognition and Measurement: Phase II of the inter-bank offered rates reform used as market benchmarks (IBOR). The amendments are summarized as: · Changes in financial assets and liabilities: Practical expedient that allows to replace, as a consequence of the reform, the effective interest rate of a financial asset or financial liability with a new economically equivalent rate, without derecognition of the contract; · Hedge accounting: End of exemptions for evaluating the effectiveness of hedge relationships (Phase I) with recognition in Profit or Loss of the ineffective portion, creation of sub-portfolios to segregate contracts with the amended rates for hedges of group items, 24-month term for identification and segregation of new risk based on changes in interest rates, and updates of hedge documentation; · Disclosure: Requirements about the disclosure of risks to which the entity is exposed by the reform, risk management and evolution of the IBORs transition. st These amendments are effective for years beginning on January 1 , 2021. ITAÚ UNIBANCO HOLDING is exposed mainly to Libor and Euribor rates in hedge accounting structures and financial assets and liabilities, including derivatives. Agreements linked to IBORs facing extinction will be (i) updated to an alternative rate plus spread; or (ii) settled in advance should there be no agreement between the parties. To mitigate the risks associated with IBOR Reform in standardized agreements, ITAÚ UNIBANCO HOLDING will assume the update of rates made by the respective clearing houses with the accretion of a spread so that the restated cash flows are economically equivalent to the original cash flows. The fallback clauses protocols suggested by international self-regulatory entities (International Swaps and Derivatives Association—ISDA) will be adopted. For the other agreements will be negotiated between the parties seeking to approach the model adopted for standardized agreements and they will be adjusted gradually until the end of 2021, date on which the market expects the end of disclosures of IBORs. Accordingly, ITAÚ UNIBANCO HOLDING does not expect significant impacts resulting from the IBOR Reform. · IFRS 17 – Insurance Contracts: The pronouncement replaces IFRS 4 – Insurance Contracts and presents three approaches for valuation: · General Model: applicable to all contracts without direct participation features; · Premium Allocation Approach (PAA): applicable to contracts with term is up to 12 months or when it produces results similar to those that would be obtained if the general model was used. It is more simplified than the general model; · Variable Fee Approach: applicable to insurance contracts with direct participation features, the insurance contracts which are substantially investment related service contracts under which an entity promises an investment return based on underlying items. Insurance contracts must be recognized based on an analysis of four components: · Expected Future Cash Flows: estimate of all components of cash flow of the contract, considering inflows and outflows; · Risk Adjustment: estimate of offset required for differences that may occur between cash flows; · Contractual Margin: difference between any amounts received before the beginning of the contract coverage and present value of cash flows estimated at the beginning of the contract; · Discount: projected cash flows must be discounted to present value, to reflect the time value of money, at rates that reflect the characteristics of the respective flows. st This standard is effective for annual periods beginning January 1 , 2023. Possible impacts are being assessed and the assessment will be completed by the date this standard comes into force. 2.3. Critical accounting estimates and judgments The preparation of Consolidated Financial Statements in accordance with the IFRS requires Management to make estimates and assumptions that affect the reported amounts of assets, liabilities, and contingent assets and liabilities at the date of the Financial Statements, due to uncertainties and the high level of subjectivity involved in the recognition and measurement of certain items. Estimates and judgments considered more relevant by ITAÚ UNIBANCO HOLDING are related to the following topics: Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 29

Topic Notes Consolidation Note 2.3 (a) and Note 3 Fair value of financial instruments Note 2.3 (b) and Note 28 Effective interest rate Note 2.3 (c), Notes 5, 8, 9 and 10 Change to financial assets Note 2.3 (d), Notes 5, 8, 9 and 10 Transfer and write-off of financial assets Note 2.3 (e), Notes 5, 8, 9 and 10 Expected credit loss Note 2.3 (f), Notes 8, 9, 10 and 32 Goodwill impairment Note 2.3 (g) and Note 14 Deferred income tax and social contribution Note 2.3 (h) and Note 24 Defined benefit pension plan Note 2.3 (i) and Note 26 Provisions, contingencies and legal liabilities Note 2.3 (j) and Note 29 Technical provisions for insurance and private pension Note 2.3 (k) and Note 27 a) Consolidation Subsidiaries are all those in which ITAÚ UNIBANCO HOLDING’s involvement exposes it or entitles it to variable returns and can affect these returns through its influence on the entity. The existence of control is assessed continuously. Subsidiaries are consolidated from the date control is established to the date on which it ceases to exist. b) Fair value of financial instruments not traded in active markets, including derivatives The fair value of financial instruments, including derivatives that are not traded in active markets, is calculated by using valuation techniques based on assumptions that consider market information and conditions. The main assumptions are: historical data, information on similar transactions and pricing techniques. For more complex or illiquid instruments, significant judgment is necessary to determine the model used with the selection of specific inputs and, in certain cases, evaluation adjustments are applied to the model amount our price quoted for financial instruments that are not actively traded. The methodologies used to estimate the fair value of certain financial instruments are described in Note 28. Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 30

c) Effective interest rate For the calculation of the effective interest rate, the ITAÚ UNIBANCO HOLDING estimates cash flows considering all contractual terms of the financial instrument, but without consider future credit losses. The calculation includes all commissions paid or received between parties to the contract, transaction costs, and all other premiums or discounts. Interest revenue is calculated by applying the effective interest rate to the gross carrying amount of a financial asset. In the case of purchased or originated credit impaired financial assets, the adjusted effective interest rate is applied (taking into account the expected credit loss) to the amortized cost of the financial asset. d) Modification of financial assets The factors used to determine whether has been substantial modification of a contract are: evaluation if there is a renegotiation that is not part of the original contractual terms, change to contractual cash flows and significant extensions of the term of the transaction due to the debtor’s financial constraints, significant changes to the interest rate and changes to the currency in which the transaction is denominated. e) Transfer and write-off of financial assets When there are no reasonable expectations of recovery of a financial asset, considering historical curves, its total or partial write-off is carried out concurrently with the use of the related allowance for expected credit loss, with no effect on the Consolidated Statement of Income of ITAÚ UNIBANCO HOLDING. Subsequent recoveries of amounts previously written off are accounted for as income in the Consolidated Statement of Income. Thus, financial assets are written off, either totally or partially, when there is no reasonable expectation of recovering a financial asset or when ITAÚ UNIBANCO HOLDING substantially transfers all risks and benefits of ownership and said transfer is qualified to be written off. f) Expected credit loss The measurement of expected credit loss requires the application of significant assumptions and use of quantitative models. Management exercises its judgment in the assessment of the adequacy of the expected loss amounts resulting from models and, according to its experience, makes adjustments that may result from certain client’s credit condition or temporary adjustments resulting from situations or new circumstances that have not been reflected in the modeling yet. The main assumptions are: · Term to maturity: ITAÚ UNIBANCO HOLDING considers the maximum contractual period on which it will be exposed a financial instrument’s credit risk. However, the estimated useful life of assets that do not have fixed maturity date is based on the period of exposure to credit risk. Additionally, all contractual terms are taken into account when determining the expected life, including prepayment and rollover options. · Prospective information: IFRS 9 requires a balanced and impartial estimate of credit loss that includes forecasts of future economic conditions. ITAÚ UNIBANCO HOLDING uses macroeconomic forecasts and public information with projections prepared internally to determine the impact of these estimates on the calculation of expected credit loss. Main prospective information used to determine the expected loss is related to Selic Rate, Credit Default Swap (CDS), unemployment rate, Gross Domestic Product (GDP), wages, industrial production and retail sales. · Macroeconomic scenarios: This information involves inherent risks, market uncertainties and other factors that may give rise to results different from expected. · Probability-weighted loss scenarios: ITAÚ UNIBANCO HOLDING uses weighted scenarios to determine credit loss expected over a suitable observation horizon adequate to classification in phases, considering the projection based on economic variables. Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 31

· Determining criteria for significant increase or decrease in credit risk: in each period of the consolidated financial statements, ITAÚ UNIBANCO HOLDING assesses whether the credit risk on a financial asset has increased significantly since the initial recognition using relative and absolute triggers (indicators), which consider delay and the probability of default (PD) by product and by country. ITAÚ UNIBANCO HOLDING assesses several factors to determine a significant increase in credit risk, such as: the counterparty, type and characteristics of the product and region in which it was contracted, considering the following objective criteria as minimum factors: · Stage 1 to stage 2: default exceeding 30 days, except for payroll loans for government agency, which are recognized is made after 45 days in arrears; · Stage 2 to stage 3: default exceeding 90 days, except for the mortgage loan portfolio, for which arrears of 180 days is a parameter for stage migration. ITAÚ UNIBANCO HOLDING assesses whether the credit risk has significantly increased on an individual or collective basis. For collective assessment purposes, financial assets are grouped based on characteristics of shared credit risk, considering the type of instrument, credit risk classifications, initial recognition date, remaining term, industry, geographical location of the counterparty, among other significant factors. · Brazilian and foreign government securities are considered to have low credit risk, in accordance with a study conducted by ITAÚ UNIBANCO HOLDING and therefore they remain in stage 1. Details on the expected credit loss are in Note 32. g) Goodwill impairment The review of goodwill due to impairment reflects the Management’s best estimate for future cash flows of Cash Generating Units (CGU), with the identification of the CGU and estimate of their fair value less costs to sell and/or value in use. These flows are subject to market conditions and uncertain factors, as follows: · Cash flows projected for periods of available forecasts and long-term assumptions for these flows; · Discount rates, since they generally reflect financial and economic variables, such as the risk-free interest rate and a risk premium. Cash-Generating Units or CGU groups are identified at the lowest level at which goodwill is monitored for internal management purposes. Goodwill is allocated to cash flow generating units for purposes of testing for impairment. h) Deferred income tax and social contribution As explained in Note 2.4j, deferred tax assets are recognized only in relation to deductible temporary differences, tax losses and social contribution loss carryforwards for offset only to the extent that it is probable that ITAÚ UNIBANCO HOLDING will generate future taxable profit for its use. The expected realization of deferred tax assets is based on the projection of future taxable profits and technical studies, as disclosed in Note 24. i) Defined benefit pension plan The current amount of pension plans is obtained from actuarial calculations, which use assumptions such as discount rate, which is appropriated at the end of each year and used to determine the present value of estimated future cash outflows. To determine the appropriate discount rate, ITAÚ UNIBANCO HOLDING considers the interest rates of National Treasury Notes that have maturity terms similar to the terms of the respective liabilities. The main assumptions for Pension plan obligations are partly based on current market conditions. Additional information is disclosed in Note 26. Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 32

j) Provisions, contingencies and legal liabilities ITAÚ UNIBANCO HOLDING periodically reviews its contingencies. These contingencies are evaluated based on management´s best estimates, taking into account the opinion of legal counsel when there is a likelihood that financial resources will be required to settle the obligations and the amounts may be reasonably estimated. Contingencies classified as probable losses are recognized in the Balance Sheet under Provisions. Contingent amounts are measured using appropriate models and criteria, despite the uncertainty surrounding the ultimate timing and amounts. Additional information is described in Note 29. k) Technical provisions for insurance and private pension Technical provisions are liabilities arising from obligations of ITAÚ UNIBANCO HOLDING to its policyholders and participants. These obligations may be short term liabilities (property and casualty insurance) or medium and long term liabilities (life insurance and pension plans). The determination of the actuarial liability is subject to several uncertainties inherent in the coverage of insurance and pension contracts, such as assumptions of persistence, mortality, disability, life expectancy, morbidity, expenses, frequency and severity of claims, conversion of benefits into annuities, redemptions and return on assets. The estimates for these assumptions are based on the historical experience of ITAÚ UNIBANCO HOLDING, benchmarks and the experience of the actuary, in order to comply with best market practices and constantly review of the actuarial liability. The adjustments resulting from these continuous improvements, when necessary, are recognized in the statement of income for the corresponding period. Additional information is described in Note 27. 2.4. Summary of main accounting practices a) Consolidation l. Subsidiaries In accordance with IFRS 10—Consolidated Financial Statements, subsidiaries are all entities in which ITAÚ UNIBANCO HOLDING holds control. The consolidated financial statements are prepared using consistent accounting policies. Intercompany asset and liability account balances, income accounts and transaction values have been eliminated. In the 3rd quarter of 2018, ITAÚ UNIBANCO HOLDING started adjusting the financial statements of its subsidiaries in Argentina to reflect the effects of hyperinflation, pursuant to IAS 29 – Financial Reporting in Hyperinflationary Economies. Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 33

The following table shows the main consolidated companies, which together represent over 95% of total consolidated assets, as well as the interests of ITAÚ UNIBANCO HOLDING in their voting capital. Functional Interest in voting Interest in total Incorporation capital % capital % (1) Activity currency country 12/31/2020 12/31/2019 12/31/2020 12/31/2019 In Brazil Banco Itaú BBA S.A. Real Brazil Financial institution 100.00% 100.00% 100.00% 100.00% Banco Itaú Consignado S.A. Real Brazil Financial institution 100.00% 100.00% 100.00% 100.00% Banco Itaucard S.A. Real Brazil Financial institution 100.00% 100.00% 100.00% 100.00% Banco Itauleasing S.A. Real Brazil Financial institution 100.00% 100.00% 100.00% 100.00% Cia. Itaú de Capitalização Real Brazil Premium Bonds 100.00% 100.00% 100.00% 100.00% Dibens Leasing S.A.—Arrendamento Mercantil Real Brazil Leasing 100.00% 100.00% 100.00% 100.00% Financeira Itaú CBD S.A. Crédito, Financiamento e Investimento Real Brazil Consumer finance credit 50.00% 50.00% 50.00% 50.00% Hipercard Banco Múltiplo S.A. Real Brazil Financial institution 100.00% 100.00% 100.00% 100.00% Itauseg Seguradora S.A. Real Brazil Insurance 100.00% 100.00% 100.00% 100.00% Itaú Corretora de Valores S.A. Real Brazil Securities Broker 100.00% 100.00% 100.00% 100.00% Itaú Seguros S.A. Real Brazil Insurance 100.00% 100.00% 100.00% 100.00% Itaú Unibanco S.A. Real Brazil Financial institution 100.00% 100.00% 100.00% 100.00% Itaú Vida e Previdência S.A. Real Brazil Pension plan 100.00% 100.00% 100.00% 100.00% Luizacred S.A. Sociedade de Crédito, Financiamento e Investimento Real Brazil Consumer finance credit 50.00% 50.00% 50.00% 50.00% Redecard S.A. Real Brazil Acquirer 100.00% 100.00% 100.00% 100.00% Foreign Itaú CorpBanca Colombia S.A. Colombian peso Colombia Financial institution 34.16% 33.22% 34.16% 33.22% Banco Itaú (Suisse) SA Swiss franc Switzerland Financial institution 100.00% 100.00% 100.00% 100.00% Banco Itaú Argentina S.A. Argentinian peso Argentina Financial institution 100.00% 100.00% 100.00% 100.00% Banco Itaú Paraguay S.A. Guarani Paraguay Financial institution 100.00% 100.00% 100.00% 100.00% Banco Itaú Uruguay S.A. Uruguayan peso Uruguay Financial institution 100.00% 100.00% 100.00% 100.00% Itau Bank, Ltd. Real Cayman Islands Financial institution 100.00% 100.00% 100.00% 100.00% Itau BBA International plc US Dollar United Kingdom Financial institution 100.00% 100.00% 100.00% 100.00% Itau BBA USA Securities Inc. Real United States Securities Broker 100.00% 100.00% 100.00% 100.00% Itaú CorpBanca (2) Chilean peso Chile Financial institution 39.22% 38.14% 39.22% 38.14% (1) All overseas offices of ITAÚ UNIBANCO HOLDING have the same functional currency as the parent company, except for CorpBanca New York Branch, which uses the US dollar. (2) ITAÚ UNIBANCO HOLDING controls ITAÚ CORPBANCA due to the shareholders’ agreement. Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 34

II. Business combinations In general, a business consists of an integrated set of activities and assets that may be conducted and managed so as to provide a return, in the form of dividends, lower costs or other economic benefits, to investors or other stockholders, members or participants. If there is goodwill in a set of activities and assets transferred, it is presumed to be a business. The acquisition method is used to account for business combinations, except for those classified as under common control. Acquisition cost is measured at the fair value of the assets transferred, equity instruments issued and liabilities incurred or assumed at the acquisition date. Acquired assets and assumed liabilities and contingent liabilities identifiable in a business combination are initially measured at fair value at the date of acquisition, regardless of the existence of non-controlling interests. When the amount paid, plus non-controlling interests, is higher than the fair value of identifiable net assets acquired, the difference will be accounted for as goodwill. On the other hand, if the difference is negative, it will be treated as bargain purchase gain and the amount will be recognized directly in income. III. Goodwill Goodwill is not amortized, but its recoverable value is assessed semi-annually or when there is an indication of impairment loss using an approach that involves the identification of Cash Generating Units (CGUs) and the estimate of its fair value less the cost to sell and/or its value in use. To determine this estimate, ITAÚ UNIBANCO HOLDING adopts the discounted cash flow methodology for a period of 5 years, macroeconomic assumptions, growth rate and discount rate. The units or Cash Flow Generating Units are identified at the lowest level in which goodwill is monitored for internal Management purposes. Goodwill is allocated to cash flow generating units for purposes of testing for impairment. The breakdown of intangible assets is described in Note 14. IV. Capital Transactions with non-controlling stockholders IFRS 10 – Consolidated Financial Statements establishes that, changes in an ownership interest in a subsidiary, which do not result in a loss of control, are accounted for as capital transactions and any difference between the amount paid and the carrying amount of non-controlling stockholders is recognized directly in consolidated stockholders’ equity. b) Foreign currency translation I. Functional and presentation currency The Consolidated Financial Statements of ITAÚ UNIBANCO HOLDING are presented in Brazilian Reais, its functional and presentation currency. For each subsidiary, joint venture or investment in associates, ITAÚ UNIBANCO HOLDING defines the functional currency as the currency of the primary economic environment in which the entity operates. II. Foreign currency operations Foreign currency operations are translated into the functional currency using the exchange rates prevailing on the dates of the transactions. Foreign exchange gains and losses are recognized in the consolidated statement of income, unless they are related to cash flow hedges and hedge of net investment in foreign operations, which are recognized in stockholders’ equity. c) Cash and cash equivalents Defined as cash and current accounts with banks, shown in the Consolidated Balance Sheet under the heading Cash, Interbank Deposits and Securities purchased under agreements to resell (Collateral Held) with original maturities not exceeding 90 days. Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 35

d) Financial assets and liabilities Financial assets and liabilities are initially recognized at fair value and subsequently measured at amortized cost or fair value. I—Classification and measurement of financial assets Financial assets are classified in the following categories: · Amortized cost: used when financial assets are managed to obtain contractual cash flows, consisting solely of payments of principal and interest; · Fair value through other comprehensive income: used when financial assets are held both for obtaining contractual cash flows, consisting solely by payments of principal and interest, and for sale; · Fair value through profit or loss: used for financial assets that do not meet the aforementioned criteria. The classification and subsequent measurement of financial assets depend on: · The business model under which they are managed; · The characteristics of their cash flows (Solely Payment of Principal and Interest Test – SPPI Test). Business model: represents how financial assets are managed to generate cash flows and does not depend on the Management’s intention regarding an individual instrument. Financial assets may be managed with the purpose of: i) obtaining contractual cash flows; ii) obtaining contractual cash flows and sale; or iii) others. To assess business models, ITAÚ UNIBANCO HOLDING considers risks that affect the performance of the business model; how the managers of the business are compensated; and how the performance of the business model is assessed and reported to Management. When a financial asset is subject to business models i) or ii) the application of the SPPI Test is required. SPPI Test: assessment of cash flows generated by a financial instrument for the purpose of checking whether they represent solely payments of principal and interest. To fit into this concept, cash flows should include only consideration for the time value of money and credit risk. If contractual terms introduce risk exposure or cash flow volatilities, such as exposure to changes in prices of equity instruments or prices of commodities, the financial asset is classified at fair value through profit or loss. Hybrid contracts must be assessed as a whole, including all embedded characteristics. The accounting of a hybrid contract that contains an embedded derivative is performed on a joint basis, i.e. the whole instrument is measured at fair value through profit or loss. Amortized cost Amortized cost is the amount for which a financial asset or liability is measured at its initial recognition, plus adjustments made under the effective interest method, less amortization of principal and interest, and any provision for expected credit loss. Fair value Fair value is the price that would be received for the sale of an asset or that would be paid for the transfer of a liability in an orderly transaction between market players on the measurement date. ITAÚ UNIBANCO HOLDING classifies the fair value hierarchy according to the relevance of data observed in the measurement process. Details of the fair value of financial instruments, including Derivatives, and of the hierarchy of fair value are given in Note 28. Average cost is used to determine the gains and losses realized on disposal of financial assets at fair value, which are recorded in the Consolidated Statement of Income as Adjustments to Fair Value of Financial Assets and Liabilities. Dividends on assets at fair value through other comprehensive Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 36

income are recognized in the Consolidated Statement of Income as Dividend income when it is probable that ITAÚ UNIBANCO HOLDING’s right to receive such dividends is assured. Regular purchases and sales of financial assets are recognized and derecognized, respectively, on the trading date. Financial assets and liabilities are offset against each other and the net amount is reported in the Balance Sheet only solely when there is a legally enforceable right to offset them and the intention to settle them on a net basis, or to simultaneously realize the asset and settle the liability. Equity instruments An equity instrument is any contract that evidences a residual interest in an entity’s assets, after the deduction of all its liabilities, such as Shares and Units. ITAÚ UNIBANCO HOLDING subsequently measures all its equity instruments at fair value through profit or loss, except when Management opts, on initial recognition, to irrevocably designate an equity instrument at fair value through other comprehensive income when it is held for a purpose other than only generating returns. When this option is selected, gains and losses on the fair value of the instrument are recognized in the Consolidated Statement of Comprehensive Income and are not subsequently reclassified to the Consolidated Statement of Income, even on sale. Dividends continue to be recognized in the Consolidated Statement of Income when ITAÚ UNIBANCO HOLDING’s right to receive them is assured. Gains and losses on equity instruments measured at fair value through profit or loss are accounted in the Consolidated Statement of Income. Expected credit loss ITAÚ UNIBANCO HOLDING makes a forward-looking assessment of the expected credit loss on financial assets measured at amortized cost or through other comprehensive income, loan commitments and financial guarantee contracts: · Financial assets: loss is measured at present value of the difference between contractual cash flows and the cash flows that ITAÚ UNIBANCO HOLDING expects to receive; · Loan commitments: expected loss is measured at present value of the difference between contractual cash flows that would be due if the commitment was drawn down and the cash flows that ITAÚ UNIBANCO HOLDING expects to receive; · Financial guarantees: the loss is measured at the difference between the payments expected for refunding the counterparty and the amounts that ITAÚ UNIBANCO HOLDING expects to recover. ITAÚ UNIBANCO HOLDING applies a three-stage approach to measuring the expected credit loss, in which financial assets migrate from one stage to the other in accordance with changes in credit risk. · Stage 1 – 12-month expected credit loss: represents default events possible within 12 months. Applicable to financial assets which are not credit impaired when purchased or originated; · Stage 2 – Lifetime expected credit loss of financial instrument: considers all possible default events. Applicable to financial assets originated which are not credit impaired when originated or purchased but for which credit risk has increased significantly; and · Stage 3 – Credit loss expected for credit-impaired assets: considers all possible default events. Applicable to financial assets which are credit impaired when purchased or originated. The measurement of assets classified in this stage is different from Stage 2 due to the recognition of interest income by applying the effective interest rate to amortized cost (net of provision) rather than to the gross carrying amount. Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 37

An asset will migrate between stages as its credit risk increases or decreases. Therefore, a financial asset that migrated to stages 2 and 3 may return to stage 1, unless it was purchased or originated credit impaired financial asset. Macroeconomic scenarios Forward-looking information is based on macroeconomic scenarios that are reassessed annually or when market conditions so require. Additional information is described in Note 32. Modification of contractual cash flows When contractual cash flows of a financial asset are renegotiated or otherwise modified and this does not substantially change its terms and conditions, ITAÚ UNIBANCO HOLDING does not derecognize it. However, the gross carrying amount of this financial asset is recalculated as the present value of the renegotiated or changed contractual cash flows, discounted at the original effective interest rate and a modification gain or loss is recognized in profit or loss. Any costs or fees incurred adjust the modified carrying amount and are amortized over the remaining term of the financial asset. If, on the other hand, the renegotiation or change substantially modifies the terms and conditions of the financial asset, ITAÚ UNIBANCO HOLDING derecognises the original asset and recognizes a new one. Accordingly, the renegotiation date is taken as the initial recognition date of the new asset for expected credit loss calculation purposes, and to determine significant increases in credit risk. ITAÚ UNIBANCO HOLDING also assesses if the new financial asset may be considered as purchased or originated credit impaired financial asset, particularly when the renegotiation was motivated by the debtor’s financial constraints. Differences between the carrying amount of the original asset and fair value of the new asset are immediately recognized in the Consolidated Statement of Income. The effects of changes in cash flows of financial assets and other details about methodologies and assumptions adopted by Management to measure the allowance for expected credit loss, including the use of prospective information, are detailed in Note 32. Derecognition of financial assets Financial assets are derecognized when ITAÚ UNIBANCO HOLDING substantially transfers all risks and benefits of its property. In the event it is not possible to identify the transfer of all risks and benefits, the control should be assessed to determine the continuous involvement related to the transaction. If there is a retention of risks and benefits, the financial asset continues to be recorded and a liability is recognized for the consideration received. II – Classification and measurement of financial liabilities Financial liabilities are initially recognized at fair value and subsequently measured at amortized cost, except for: · Financial liabilities at fair value through profit or loss: this classification applied to derivatives and other financial liabilities designated at fair value through profit or loss to reduce “accounting mismatches”. ITAÚ UNIBANCO HOLDING irrevocably designates financial liabilities at fair value through profit or loss in the initial recognition (fair value option), when the option eliminates or significantly reduces measurement or recognition inconsistencies. · Loan commitments and financial guarantees: see details in Note 2.4d Vll. Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 38

Derecognition and modification of financial liabilities ITAÚ UNIBANCO HOLDING derecognises a financial liability from the Consolidated Balance Sheet when it is extinguished, i.e., when the obligation specified in the contract is discharged, cancelled or expires. A debt instrument change or substantial terms modification of a financial liability is accounted as a derecognition of the original financial liability and a new one is recognized. A substantial change to contractual terms occurs when the discounted present value of cash flows under the new terms, including any fees paid/received and discounted using the original effective interest rate, is at least 10% different from discounted present value of the remaining cash flow of the original financial liabilities. III – Securities purchased under agreements to resell ITAÚ UNIBANCO HOLDING purchases financial assets with a resale commitment (resale agreements) and sells securities with a repurchase commitment (repurchase agreement) of financial assets. Resale and repurchase agreements are accounted for under Securities purchased under agreements to resell and Securities sold under repurchase agreements, respectively. The difference between the sale and repurchase prices is treated as interest and recognized over the life of the agreements using the effective interest rate method. The financial assets taken as collateral in resale agreements can be used as collateral for repurchase agreements it provided for in the agreements or can be sold. IV—Derivatives All derivatives are accounted for as financial assets when the fair value is positive and as financial liabilities when the fair value is negative. The valuation of active hybrid contracts that are subject to IFRS 9 is carried out as a whole, including all embedded characteristics, whereas the accounting is carried out on a joint basis, i.e. each instrument is measured at fair value through profit or loss. When a contract has a main component outside the scope of IFRS 9, such as a lease agreement receivable or an insurance contract, or even a financial liability, embedded derivatives are treated as separate financial instruments if: (i) their characteristics and economic risks are not closely related to those of the main component; (ii) the separate instrument meets the definition of a derivative; and (iii) the underlying instrument is not booked at fair value through profit or loss. These embedded derivatives are accounted for separately at fair value, with variations recognized in the Consolidated Statement of Income as Adjustments to Fair Value of Financial Assets and Liabilities. ITAÚ UNIBANCO HOLDING will continue applying all the hedge accounting requirements of IAS 39; however, it may adopt the provisions of IFRS 9, if Management so decides. According to this standard, derivatives may be designated and qualified as hedging instruments for accounting purposes and, the method for recognizing gains or losses of fair value will depending on the nature of the hedged item. At the beginning of a hedging transaction, ITAÚ UNIBANCO HOLDING documents the relationship between the hedging instrument and the hedged items, as well as its risk management objective and strategy. The hedge is assessed on an ongoing basis to determine if it has been highly effective throughout all periods of the Financial Statements for which it was designated. IAS 39 describes three hedging strategies: fair value hedge, cash flow hedge, and hedge of net investments in a foreign operation. ITAÚ UNIBANCO HOLDING uses derivatives as hedging instruments under all three hedge strategies, as detailed in Note 7. Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 39

Fair value hedge The following practices are adopted for these operations: a) The gain or loss arising from the remeasurement of the hedging instrument at fair value is recognized in income; and b) The gain or loss arising from the hedged item, attributable to the effective portion of the hedged risk, is applied to the book value of the hedged item and is also recognized in income. When a derivative expires or is sold or a hedge no longer meets the hedge accounting criteria or in the event the designation is revoked, the hedge accounting must be prospectively discontinued. In addition, any adjustment to the book value of the hedged item must be amortized in income. Cash flow hedge For derivatives that are designated and qualify as hedging instruments in a cash flow hedge, the practices are: a) The effective portion of gains or losses on derivatives is recognized directly in Other comprehensive income – Cash flow hedge; b) The portion of gain or loss on derivatives that represents the ineffective portion or on hedge components excluded from the assessment of effectiveness is recognized in income. Amounts originally recorded in Other comprehensive income and subsequently reclassified to Income are recognized in the caption Interest, similar income and dividend of financial assets at fair value through profit or loss at the same time that the corresponding income or expense item of the financial hedge item affects income. For non-financial hedge items, the amounts originally recognized in Other Comprehensive Income are included in the initial cost of the corresponding asset or liability. When a derivative expires or is sold, when hedge accounting criteria are no longer met or when the entity revokes the hedge accounting designation, any cumulative gain or loss existing in Other comprehensive income will be reclassified to income at the time the expected transaction occurs or is no longer expected to occur. Hedge of net investments in foreign operations The hedge of a net investment in a foreign operation, including the hedge of a monetary item that is booked as part of the net investment, is accounted for in a manner similar to a cash flow hedge: a) The portion of gain or loss on the hedging instrument determined as effective is recognized in other comprehensive income; b) The ineffective portion is recognized in income. Gains or losses on the hedging instrument related to the effective portion of the hedge which are recognized in Other comprehensive income are reclassified to income for the period when the foreign operation is partially or totally sold. V—Loan operations ITAÚ UNIBANCO HOLDING classifies a loan as non-performing if the payment of the principal or interest has been overdue for 60 days or more. In this case, accrual of interest is no longer recognized. VI – Premium bonds plans In Brazil they are regulated by the insurance regulator. These plans do not meet the definition of an insurance contract under IFRS 4, and therefore they are classified as a financial liability at amortized cost under IFRS 9. Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 40

Revenue from premium bonds plans is recognized during the period of the contract and measured as the difference between the amount deposited by the customer and the amount that ITAÚ UNIBANCO HOLDING has to reimburse. VII – Loan commitments and financial guarantees ITAÚ UNIBANCO HOLDING recognizes as an obligation in the Consolidated Balance Sheet, on the issue date, the fair value of commitments for loans and financial guarantees. The fair value is generally represented by the fee charged to the customer. This amount is amortized over the term of the instrument and is recognized in the Consolidated Statement of Income under the heading Commissions and Banking Fees. After issue, if ITAÚ UNIBANCO HOLDING concludes based on the best estimate, that the expected credit loss in relation to the guarantee issued is higher that the fair value less accumulated amortization, this amount is replaced by a provision for loss. e) Investments in associates and joint ventures I – Associates Associates are companies in which the investor has a significant influence but does not hold control. Investments in these companies are initially recognized at cost of acquisition and subsequently accounted for using the equity method. Investments in associates and joint ventures include the goodwill identified upon acquisition, net of any cumulative impairment loss. II – Joint ventures ITAÚ UNIBANCO HOLDING has joint venture whereby the parties that have joint control of the arrangement have rights to the net assets. ITAÚ UNIBANCO HOLDING’s share in profits or losses of its associates and joint ventures after acquisition is recognized in the Consolidated statement of income. Its share of the changes in the share in other comprehensive income of corresponding stockholders’ equity of its associates and joint ventures is recognized in its own capital reserves. The cumulative changes after acquisition are adjusted against the carrying amount of the investment. When the ITAÚ UNIBANCO HOLDING’s share of losses in an associates and joint ventures is equal to or more than the value of its interest, including any other receivables, ITAÚ UNIBANCO HOLDING does not recognize additional losses, unless it has incurred any obligations or made payments on behalf of the associates and joint ventures. Unrealized profits on transactions between ITAÚ UNIBANCO HOLDING and its associates and joint ventures are eliminated to the extent of the interest of ITAÚ UNIBANCO HOLDING. Unrealized losses are also eliminated, unless the transaction provides evidence of impairment of the transferred asset. The accounting policies on associates and joint ventures entities are changed, as necessary, to ensure consistency with the policies adopted by ITAÚ UNIBANCO HOLDING. If its interest in the associates and joint ventures decreases, but ITAÚ UNIBANCO HOLDING retains significant influence or joint control, only the proportional amount of the previously recognized amounts in Other comprehensive income is reclassified in Income, when appropriate. f) Lessee operations ITAÚ UNIBANCO HOLDING leases mainly real estate properties (underlying assets) to carry out its business activities. The initial recognition occurs when the agreement is signed, in the heading Other Liabilities, which corresponds to the total future payments at present value as a contra entry to the Right-of-Use Assets, depreciated under the straight-line method for the lease term and tested semiannually to identify possible impairment losses. The financial expense corresponding to interest on lease liabilities is recognized in the heading Interest and Similar Expense in the Consolidated Statement of Income. Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 41

g) Fixed assets Fixed assets are booked at their acquisition cost less accumulated depreciation, and adjusted for impairment, if applicable. Depreciation is calculated on the straight-line method using rates based on the estimated useful lives of these assets. Such rates and other details are presented in Note 13. The residual values and useful lives of assets are reviewed and adjusted, if appropriate, at the end of each period. ITAÚ UNIBANCO HOLDING reviews its assets in order to identify indications of impairment in their recoverable amounts. The recoverable amount of an asset is defined as the higher of its fair value less the cost to sell and its value in use. For the purposes of assessing impairment, assets are grouped at the lowest level for which independent cash flows can be identified (cash-generating units). The assessment may be made at an individual asset level when the fair value less the cost to sell can be reliably determined. Gains and losses on disposals of fixed assets are recognized in the Consolidated statement of income under Other income or General and administrative expenses. h) Intangible assets Intangible assets are non-physical assets, including software and other assets, and are initially recognized at cost. Intangible assets are recognized when they arise from legal or contractual rights, their costs can be reliably measured, and in the case of intangible assets not arising from separate acquisitions or business combinations, it is probable that future economic benefits may arise from their use. The balance of intangible assets refers to acquired assets or those internally generated. Intangible assets may have definite or indefinite useful lives. Intangible assets with definite useful lives are amortized using the straight-line method over their estimated useful lives. Intangible assets with indefinite useful lives are not amortized, but periodically tested in order to identify any impairment. ITAÚ UNIBANCO HOLDING semi-annually assesses its intangible assets in order to identify whether any indications of impairment exist, as well as possible reversal of previous impairment losses. If such indications are found, intangible assets are tested for impairment. The recoverable amount of an asset is defined as the higher of its fair value less the cost to sell and its value in use. For the purposes of assessing impairment, assets are grouped at the lowest level for which independent cash flows can be identified (cash-generating units). The assessment may be made at an individual asset level when the fair value less the cost to sell can be reliably determined. ITAÚ UNIBANCO HOLDING uses the cost model to measure its intangible assets after its initial recognition. A breakdown of intangible assets is given in Note 14. i) Assets held for sale Assets held for sale are recognized in the consolidated balance sheet under the line Other assets when they are actually repossessed or there is intention to sell. These assets are initially recorded at the lower of: (i) the fair value of the asset less the estimated selling expenses, or (ii) the carrying amount of the related asset held for sale. j) Income tax and social contribution There are two components of the provision for income tax and social contribution: current and deferred. The current component is approximately the total of taxes to be paid or recovered during the reporting period. Deferred income tax and social contribution, represented by deferred tax assets and liabilities, is obtained based on the differences between the tax bases of assets and liabilities and the amounts reported in the financial statements at each year end. The income tax and social contribution expense is recognized in the Consolidated statement of income under Income tax and social contribution, except when it refers to items directly recognized in Other Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 42

comprehensive income, such as: tax on fair value of financial assets measured at fair value through Other comprehensive income, post-employment benefits and tax on cash flow hedges and hedge of net investment in foreign operations. Subsequently, these items are recognized in income upon realization of the gain/loss on the instruments. Changes in tax legislation and rates are recognized in the Consolidated statement of income in the period in which they are enacted. Interest and fines are recognized in the Consolidated statement of income under General and administrative expenses. To determine the proper level of provisions for taxes to be maintained for uncertain tax positions, the approach applied, is that a tax benefit is recognized if it is more likely than not that a position can be sustained, under the assumptions for recognition, detailed in item 2.4 n. k) Insurance contracts and private pensions Insurance contracts are contracts under which ITAÚ UNIBANCO HOLDING accepts a significant insurance risk of the counterparty, by agreeing to compensate it if a specified uncertain future event adversely affects it. An insurance risk is significant only if the insurance event could cause ITAÚ UNIBANCO HOLDING to pay significant additional benefits in any scenario, other than those that do not have commercial substance. Additional benefits refer to amounts that exceed those that would be payable if no insured event occurred. Upon its first-time adoption of the IFRS, ITAÚ UNIBANCO HOLDING decided not to change its accounting policies for insurance contracts, which follow the accounting practices generally accepted in Brazil (“BRGAAP”). Although investment agreements with discretionary participation characteristics are financial instruments, they are treated as insurance contracts, as established by IFRS 4, as well as those transferring a significant financial risk. Once a contract is classified as an insurance contract, it remains as such until the end of its life, even if the insurance risk is significantly reduced during the period, unless all rights and obligations are extinguished or expire. Note 27 provides a detailed description of all products classified as insurance contracts. Private pension plans Contracts that provide for retirement benefits after an accumulation period (known as PGBL, VGBL and FGB) provide a guarantee, at the commencement date of the contract, of the basis for calculating the retirement benefit (mortality table and minimum interest rates). The contracts specify the annuity rates and, therefore, the insurance risk is transferred to the issuer from the start. These contracts are classified as insurance contracts. Insurance premiums Insurance premiums are recognized upon issue of an insurance policy or over the period of the contracts in proportion to the amount of the insurance coverage. If there is evidence of impairment losses with respect to receivables for insurance premiums, ITAÚ UNIBANCO HOLDING recognizes a provision, sufficient to cover this loss, based on a risk analysis of realization of insurance premiums receivable with installments overdue for over 60 days. Reinsurance In the ordinary course of business, ITAÚ UNIBANCO HOLDING reinsures a portion of the risks underwritten, particularly property and casualty risks that exceed the maximum limits of responsibility that determine to be appropriate for each segment and product (after a study which considers size, experience, special features, and the capital necessary to support these limits). These reinsurance agreements allow the recovery of a portion of the losses from the reinsurer, although they do not release the insurer from the main obligation as direct insurer of the risks covered by the reinsurance. Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 43

ITAÚ UNIBANCO HOLDING mainly holds non-proportional contracts, which transfer part of responsibility to the reinsurance company for losses that will materialize after a certain level of claims in the portfolio. Reinsurance premiums of these contracts are accounted for under Other Assets, over the life of each contract. If there is any evidence of impairment loss, ITAÚ UNIBANCO HOLDING recognizes a provision when the default period exceeds 180 days from the registration of the request for fund of claims paid. Acquisition costs Acquisition costs include direct and indirect costs related to the origination of insurance. These costs are recorded directly in result as incurred, except for deferred acquisition costs (commissions paid for brokerage services, agency and prospecting efforts), which are recorded proportionally to the recognition of premium revenues, i.e. over the term corresponding to the insurance contract. Insurance Contract Liabilities Reserves for claims are established based on past experience, claims in process of payment, estimated amounts of claims incurred but not yet reported, and other factors relevant to the required reserve levels. Liability Adequacy Test ITAÚ UNIBANCO HOLDING tests liability adequacy by adopting current actuarial assumptions for future cash flows of all insurance contracts in force at the balance sheet date. Should the analysis show insufficiency, any shortfall identified will immediately be accounted for in income for the period. The assumptions used to conduct the liability adequacy test are detailed in Note 27. l) Post-employments benefits ITAÚ UNIBANCO HOLDING sponsors Defined Benefit Plans and Defined Contribution Plans, which are accounted for in accordance with IAS 19 – Benefits to Employees. ITAÚ UNIBANCO HOLDING is required to make contributions to government social security and labor indemnity plans, in Brazil and in other countries where it operates. Pension plans—Defined benefit plans The liability or asset, as the case may be, is recognized in the Consolidated Balance Sheet with respect to a defined benefit plan corresponds to the present value of defined benefit obligations at the balance sheet date less the fair value of plan assets. The defined benefit obligations are calculated annually using the projected unit credit method. Pension plans—Defined contribution For defined contribution plans, contributions to plans made by ITAÚ UNIBANCO HOLDING, through pension plan funds, are recognized as liabilities, with a counter-entry to expenses, when due. If contributions made exceed the liability for a service provided, it will be accounted for as an asset recognized at fair value, and any adjustments are recognized in Stockholders’ equity, under Other comprehensive income, in the period when they occur. Other post-employment benefit obligations Like defined benefit pension plans, these obligations are assessed annually by independent, qualified actuaries, and costs expected from these benefits are accrued over the period of employment. Gains and losses arising from changes in practices and variations in actuarial assumptions are recognized in Stockholders’ equity, under Other comprehensive income, in the period in which they occur. Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 44

m) Share-based payments Share-based payments are booked for the value of equity instruments granted, which may be shares or stock options according to the plan, based on their fair value at the grant date. This cost is recognized during the vesting period of the right to exercise the instruments. The total amount to be expensed is determined by reference to the fair value of the equity instruments excluding the impact of any service commissions and fees and non-market performance vesting conditions (in particular when an employee remains with the company for specific period of time). n) Provisions, contingent assets and contingent liabilities Contingent assets and liabilities are possible rights and potential obligations arising from past events for which realization depends on uncertain future events. Contingent assets are not recognized in the Consolidated Financial Statements, except when the Management of ITAÚ UNIBANCO HOLDING considers that realization is practically certain. In general they correspond to lawsuits with favorable outcomes in final and unappealable judgments and to the withdrawal of lawsuits as a result of a settlement payment received or an agreement for set-off against an existing liability. These contingencies are evaluated based on Management’s best estimates, and are classified as: · Probable: in which liabilities are recognized in the consolidated balance sheet under Provisions; · Possible: which are disclosed in the Consolidated Financial Statements, but no provision is recorded; · Remote: which require neither a provision nor disclosure. The amount of deposits in guarantee is adjusted in accordance with current legislation. o) Capital Common and preferred shares, which for accounting purposes are equivalent to common shares but without voting rights are classified in Stockholders’ equity. The additional costs directly attributable to the issue of new shares are included in Stockholders’ equity as a deduction from the proceeds, net of taxes. p) Treasury shares Common and preferred shares repurchased are recorded in Stockholders’ equity under Treasury shares at their average purchase price. Shares that are subsequently sold, such as those sold to grantees under our share-based payment scheme, are recorded as a reduction in treasury shares, measured at the average price of treasury stock held at that date. The difference between the sale price and the average price of the treasury shares is recorded as a reduction or increase in Additional paid-in capital. The cancellation of treasury shares is recorded as a reduction in Treasury shares against Appropriated reserves, at the average price of treasury shares at the cancellation date. q) Dividends and interest on capital Minimum dividend amounts established in the bylaws are recorded as liabilities at the end of each year. Any other amount above the mandatory minimum dividend is accounted for as a liability when approved by of the Board of Directors. Interest on capital is treated for accounting purposes as a dividend, and it is presented as a reduction of stockholders’ equity in the consolidated financial statements. Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 45

Dividends have been and continue to be calculated and paid on the basis of the financial statements prepared under Brazilian accounting standards and regulations for financial institutions, not these Consolidated financial statements prepared according to the IFRS. Dividends and interest on capital are presented in Note 19. r) Earnings per share ITAÚ UNIBANCO HOLDING grants stock options whose dilutive effect is reflected in diluted earnings per share, with the application of the “treasury stock method“. Whereby earnings per share are calculated as if all the stock options had been exercised and the proceeds used to purchase shares of ITAÚ UNIBANCO HOLDING. Earnings per share are presented in Note 25. s) Segment information Segment information disclosed is consistent with the internal reports prepared for the Executive Committee which makes the operational decisions ITAÚ UNIBANCO HOLDING. ITAÚ UNIBANCO HOLDING has three reportable segments: (i) Retail Banking (ii) Wholesale Banking and (iii) Market + Corporation. Segment information is presented in Note 30. t) Commissions and Banking Fees Commissions and Banking Fees is recognized when ITAÚ UNIBANCO HOLDING provides or offers services to customers, in an amount that reflects the consideration ITAÚ UNIBANCO HOLDING expects to collect in exchange for those services. A five-step model is applied to account for revenues: i) identification of the contract with a customer; ii) identification of the performance obligations in the contract; iii) determination of the transaction price; iv) allocation of the transaction price to the performance obligations in the contract; and v) revenue recognition, when performance obligations agreed upon in agreements with clients are met. Incremental costs and costs to fulfill agreements with clients are recognized as an expense as incurred. The main services provided by ITAÚ UNIBANCO HOLDING are: · Credit and debit cards—refer mainly to fees charged by card issuers and acquirers for processing card transactions; annuities charged for the availability and management of credit card; and the rental of Rede machines. · Current account services—substantially comprised of current account maintenance fees, according to each service package granted to the customer; transfers carried through TED/DOC; withdrawals from demand deposit account and money order. · Economic, Financial and Brokerage Advisory - refer mainly to financial transaction structuring services; placement of securities, and intermediation of operations on stock exchanges. Service revenues related to credit, debit, current account and economic, financial and brokerage advisory cards are recognized when said services are provided. · Funds management—refers to fees charged for the management and performance of investment funds and consortia administration. · Credit operations and financial guarantees provided—refer mainly to advance depositor fees; asset appraisal service; and commission on guarantees provided. · Collection services—refer to collection and charging services. Revenue from certain services, such as fees from funds management, collection and custody, are recognized over the life of the respective agreements, as services are provided. Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 46

Note 3 – Business development Recovery do Brasil Consultoria S.A. On December 31, 2015, ITAÚ UNIBANCO HOLDING, through its subsidiary Itaú Unibanco S.A., (ITAÚ UNIBANCO), entered into an agreement for purchase and sale and other covenants with Banco BTG Pactual S.A. (BTG) and with Misben S.A. for acquisition of 89.08% of interest in capital of Recovery do Brasil Consultoria S.A. (RECOVERY), corresponding to total interest of RECOVERY’s parties, for the amount of R$ 735. On July 7, 2016 an additional interest of 6.92% was acquired from International Finance Corporation, for the amount of R$ 59, then holding 96% of its capital. On May 26, 2020, ITAÚ UNIBANCO HOLDING, through its subsidiary ITAÚ UNIBANCO, acquired from International Finance Corporation an additional interest of 4% for the amount of R$ 20.7, then holding 100% of capital of RECOVERY. The effective acquisition and financial settlement occurred on May 28, 2020. Acquisition of Zup I.T. Serviços em Tecnologia e Inovação S.A. On October 31, 2019, ITAÚ UNIBANCO HOLDING, through its subsidiary Redecard S.A. (REDE), entered into a purchase and sale agreement of 100% of the capital of Zup I.T. Serviços em Tecnologia e Inovação S.A. (ZUP). The purchase will be carried out in three phases over four years. In the first phase, ITAÚ UNIBANCO HOLDING acquired 52.96% of ZUP’s total voting capital for approximately R$ 293, then holding the company’s control. In the third year, after the operation is closed, ITAÚ UNIBANCO HOLDING will acquire an additional 19.6% interest; in the fourth year, the remaining interest, so as to achieve 100% of ZUP’s capital. Effective acquisitions and financial settlements occurred on March 31, 2020, after obtaining the regulatory authorizations required. Acquisition of non-controlling interest in Pravaler S.A. On December 27, 2019, ITAÚ UNIBANCO HOLDING, through its subsidiary ITAÚ UNIBANCO, increased its ownership interest in Pravaler S.A. (PRAVALER), acquiring 43.07% of total capital social (corresponding to 75.71% of preferred shares and 28.65% of common shares) for the amount of R$ 330.9. PRAVALER, with head office in São Paulo, is the manager of the largest private college loan program in Brazil, and it will continue operating independently from ITAÚ UNIBANCO HOLDING. PRAVALER is classified as an associate measured under the equity method. Effective acquisitions and financial settlements occurred on the same date, after obtaining the regulatory authorizations required. Reduction of non-controlling interest in XP Inc. On November 29, 2019, there was a corporate reorganization of XP Investimentos S.A., in which the shareholders subscribed their respective shares of the holding company XP Inc. (XP INC), keeping the percentages in total capital. After the initial public offering held on December 11, 2019 at Nasdaq in New York, the ownership interest of ITAÚ UNIBANCO HOLDING changed from 49.9% to 46.05%, giving rise to a R$ 1,991 result in the primary subscription of XP Inc. On November 26, 2020, ITAÚ UNIBANCO HOLDING disclosed that the Board of Directors approved the partial spin-off of the investment in XP INC for a new company (XPart S.A.). On December 2 and 17, 2020, ITAÚ UNIBANCO HOLDING sold 4.44% and 0.07%, respectively, of its investments in XP INC, through the public offering on the Nasdaq, giving rising to a result before taxes of R$ 3,996. Concurrently with the sales, XP INC completed a public offering (follow-on) which resulted in the dilution of the interest held by ITAÚ UNIBANCO HOLDING, which is now 41.00% of capital, giving rising to a result in XP INC primary subscription of R$ 545. Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 47

Acquisition of non-controlling interest in Ticket Serviços S.A. On September 4, 2018, ITAÚ UNIBANCO HOLDING, through its subsidiary ITAÚ UNIBANCO, entered into a strategic partnership with Edenred Participações S.A. (EDENRED) in the benefits market for workers covered mainly by PAT, the Workers’ Meals Program. EDENRED is the parent company of Ticket Serviços S.A. (TICKET) in Brazil. The strategic partnership enables ITAÚ UNIBANCO to add the benefits issued by TICKET to its current range of products and services for customers in the wholesale, medium, micro and small company segments. In addition, ITAÚ UNIBANCO made a minority investment of 11% in TICKET, through a capital increase with contribution of (i) cash, equivalent to said interest in the company’s equity value, and (ii) right to exclusive distribution of Ticket Restaurante, Ticket Alimentação, Ticket Cultura and Ticket Transporte products to the ITAÚ UNIBANCO legal entities base during the partnership term. TICKET will continue distributing its products through other commercial agreements and will continue under EDENRED’s control and management. Effective acquisitions and financial settlements occurred on August 30, 2019, after obtaining the regulatory authorizations required. Itaú CorpBanca Itaú Corpbanca (ITAÚ CORPBANCA) is controlled as of April 1st, 2016 by ITAÚ UNIBANCO HOLDING. On the same date, ITAU UNIBANCO HOLDING entered into a shareholders’ agreement with Corp Group, which sets forth, among others, the right of ITAÚ UNIBANCO HOLDING and Corp Group to appoint members for the Board of Directors of ITAÚ CORPBANCA in accordance to their interests in capital stock, and this group of shareholders have the right to appoint the majority of members of the Board of Directors of ITAÚ CORPBANCA and ITAÚ UNIBANCO HOLDING are be entitled to appoint the majority of members elected by this block. On September 10, 2020, ITAÚ UNIBANCO HOLDING, through its subsidiary ITB Holding Brasil Participações Ltda, indirectly acquired additional ownership interest of 1.08% (5,558,780,153 shares) in the ITAÚ CORPBANCA’s capital for the amount of R$ 229, and now it holds 39.22%. The effective acquisition and financial settlement occurred on September 14, 2020, after obtaining the regulatory authorizations. Note 4—Interbank deposits and securities purchased under agreements to resell 12/31/2020 12/31/2019 Non- Non- Current Total Current Total current current Securities purchased under agreements to 239,848 87 239,935 198,260 162 198,422 resell(1) Collateral held 63,087 87 63,174 44,901 162 45,063 Collateral repledge 150,591—150,591 134,116—134,116 Assets received as collateral with right to sell or 20,367—20,367 6,644—6,644 repledge Assets received as collateral without right to sell 130,224—130,224 127,472—127,472 or repledge Collateral sold 26,170—26,170 19,243—19,243 Interbank deposits 48,586 7,051 55,637 31,075 3,506 34,581 Total (2) 288,434 7,138 295,572 229,335 3,668 233,003 (1) The amounts of R$ 11,119 (R$ 8,544 at 12/31/2019) are pledged in guarantee of operations on B3 S.A.—Brasil, Bolsa, Balcão (B3) and Central Bank of Brazil and the amounts of R$ 176,760 (R$ 153,359 at 12/31/2019) are pledged in guarantee of repurchase commitment transactions. (2) Includes losses in the amounts of R$ (56) (R$ (8) at 12/31/2019). Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 48

Note 5 – Financial assets at fair value through profit or loss and designated at fair value through profit or loss—Securities a) Financial assets at fair value through profit or loss—Securities are presented in the following table: 12/31/2020 12/31/2019 Adjustments to Fair Adjustments to Fair Cost (2) Fair value Cost Fair value Value (in Income) Value (in Income) Investment funds 15,407 (1,203) 14,204 9,277 (1,010) 8,267 Brazilian government securities (1a) 284,280 1,605 285,885 218,548 1,063 219,611 Government securities – abroad (1b) 8,199 11 8,210 1,541 (21) 1,520 Argentina 1,480 18 1,498 349 (31) 318 Chile 839 1 840 487 1 488 Colombia 3,599 4 3,603 399 10 409 United States 2,096 (11) 2,085 141—141 Mexico 5—5 57—57 Paraguay 3—3 2—2 Peru 4 1 5 8—8 Uruguay 40 1 41 98 (1) 97 Italy 133 (3) 130 ——Corporate securities (1c) 78,113 (1,081) 77,032 51,744 (1,102) 50,642 Shares 20,063 (1,016) 19,047 15,459 (822) 14,637 Rural product note 2,371 (22) 2,349 — -Bank deposit certificates 729—729 792—792 Real estate receivables certificates 561 (13) 548 1,414 30 1,444 Debentures 30,022 (85) 29,937 12,958 (303) 12,655 Eurobonds and other 2,341 42 2,383 2,178 (5) 2,173 Financial bills 15,784 (1) 15,783 18,517 (3) 18,514 Promissory notes 5,588 28 5,616 313—313 Other 654 (14) 640 113 1 114 Total 385,999 (668) 385,331 281,110 (1,070) 280,040 (1) Financial assets at fair value through profit or loss – Securities pledged as Guarantee of Funding of Financial Institutions and Customers were: a) R$ 12,181 (R$ 28,759 at 12/31/2019), b) R$ 765 (R$ 329 at 12/31/2019) and c) R$ 8,556 (R$ 104 at 12/31/2019), totaling R$ 21,502 (R$ 29,192 at 12/31/2019). (2) In the period, the result of Adjustment to Fair Value of Financial Assets (particularly private securities) had their amounts affected by oscillations of rates and other market variables arising from the impact of the COVID-19 pandemic on the macroeconomic scenario in the period (Note 33a). Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 49

The cost and fair value per maturity of Financial Assets at Fair Value Through Profit or Loss—Securities were as follows: 12/31/2020 12/31/2019 Cost Fair value Cost Fair value Current 152,413 150,298 82,183 80,372 Non-stated maturity 35,470 33,251 24,736 22,904 Up to one year 116,943 117,047 57,447 57,468 Non-current 233,586 235,033 198,927 199,668 From one to five years 175,530 176,651 136,727 137,186 From five to ten years 37,783 37,600 41,744 41,759 After ten years 20,273 20,782 20,456 20,723 Total 385,999 385,331 281,110 280,040 Financial Assets at Fair Value Through Profit or Loss—Securities include assets with a fair value of R$ 205,820 (R$ 204,530 at 12/31/2019) that belong to investment funds wholly owned by Itaú Vida e Previdência S.A The return of those assets (positive or negative) is fully transferred to customers of our PGBL and VGBL private pension plans whose premiums (net of fees) are used by our subsidiary to purchase quotas of those investment funds. b) Financial assets designated at fair value through profit or loss—Securities are presented in the following table: 12/31/2020 Adjustments to Cost Fair value Fair Value (in Income) Brazilian external debt bonds 3,699 41 3,740 Total 3,699 41 3,740 12/31/2019 Adjustments to Cost Fair value Fair Value (in Income) Brazilian external debt bonds 1,016 19 1,035 Total 1,016 19 1,035 The cost and fair value by maturity of financial assets designated as fair value through profit or loss—Securities were as follows: 12/31/2020 12/31/2019 Cost Fair value Cost Fair value Current 1,806 1,826 592 609 Up to one year 1,806 1,826 592 609 Non-current 1,893 1,914 424 426 From one to five years 1,893 1,914 424 426 Total 3,699 3,740 1,016 1,035 Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 50

Note 6 – Derivatives ITAÚ UNIBANCO HOLDING trades in derivative financial instruments with various counterparties to manage its overall exposures and to assist its customers in managing their own exposures. Futures – Interest rate and foreign currency futures contracts are commitments to buy or sell a financial instrument at a future date, at an agreed price or yield, and may be settled in cash or through delivery. The notional amount represents the face value of the underlying instrument. Commodity futures contracts or financial instruments are commitments to buy or sell commodities (mainly gold, coffee and orange juice) at a future date, at an agreed price, which are settled in cash. The notional amount represents the quantity of such commodities multiplied by the future price on the contract date. Daily cash settlements of price movements are made for all instruments. Forwards – Interest rate forward contracts are agreements to exchange payments on a specified future date, based on the variation in market interest rates from trade date to contract settlement date. Foreign exchange forward contracts represent agreements to exchange the currency of one country for the currency of another at an agreed price, on an agreed settlement date. Financial instrument forward contracts are commitments to buy or sell a financial instrument on a future date at an agreed price and are settled in cash. Swaps – Interest rate and foreign exchange swap contracts are commitments to settle in cash on a future date or dates the differentials between specific financial indices (either two different interest rates in a single currency or two different rates each in a different currency), as applied to a notional principal amount. Swap contracts shown under Other in the table below correspond substantially to inflation rate swap contracts. Options – Option contracts give the purchaser, for a fee, the right, but not the obligation, to buy or sell a financial instrument within a limited time, including a flow of interest, foreign currencies, commodities, or financial instruments at an agreed price that may also be settled in cash, based on the differential between specific indices. Credit Derivatives – Credit derivatives are financial instruments with value deriving from the credit risk on debt issued by a third party (the reference entity), which permits one party (the buyer of the hedge) to transfer the risk to the counterparty (the seller of the hedge). The seller of the hedge must pay out as provided for in the contract if the reference entity undergoes a credit event, such as bankruptcy, default or debt restructuring. The seller of the hedge receives a premium for the hedge but, on the other hand, assumes the risk that the underlying instrument referenced in the contract undergoes a credit event, and the seller may have to make payment to the purchaser of the hedge for up to the notional amount of the credit derivative. The total value of margins pledged in guarantee by ITAÚ UNIBANCO HOLDING was R$ 18,000 (R$ 15,823 at 12/31/2019) and was basically comprised of government securities. Further information on internal controls and parameters used to management risks, may be found in Note 32 – Risk and Capital Management. Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 51

I—Derivatives Summary See below the composition of the Derivative financial instruments portfolio (assets and liabilities) by type of instrument, stated fair value and maturity date. 12/31/2020 (*) Over 720 Fair value % 0-30 31-90 91-180 181-365 366-720 days Assets Swaps – adjustment receivable 46,019 60.2 4,064 515 629 1,808 5,117 33,886 Option agreements 20,418 26.7 10,103 2,325 523 5,935 992 540 Forwards (onshore) 2,085 2.7 1,323 367 297 93 5—Credit derivatives 156 0.2 — 8 7 29 112 NDF—Non Deliverable Forward 7,596 9.9 2,088 2,345 1,387 1,255 323 198 Other Derivative Financial Instruments 230 0.3 56 1 6 1 12 154 Total 76,504 100.0 17,634 5,553 2,850 9,099 6,478 34,890 % per maturity date 23.0 7.3 3.7 11.9 8.5 45.6 12/31/2020 (*) Over 720 Fair value % 0-30 31-90 91-180 181-365 366-720 days Liabilities Swaps – adjustment payable (51,789) 65.1 (7,344) (651) (1,135) (1,826) (5,573) (35,260) Option agreements (20,262) 25.5 (6,355) (1,969) (543) (9,869) (998) (528) Forwards (onshore) (905) 1.1 (892)—(11) (2) — Credit derivatives (76) 0.1 ——(2) (9) (65) NDF—Non Deliverable Forward (6,426) 8.1 (2,200) (1,669) (1,013) (972) (301) (271) Other Derivative Financial Instruments (47) 0.1—(1) (10) (1) (14) (21) Total (79,505) 100.0 (16,791) (4,290) (2,712) (12,672) (6,895) (36,145) % per maturity date 21.1 5.4 3.4 15.9 8.7 45.5 (*) In the period, the result of Derivative had its amounts affected by oscillations of rates and other market variables arising from the impact of the COVID-19 pandemic on the macroeconomic scenario in the period (Note 33a). Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 52

See below the composition of the Derivative financial instruments portfolio (assets and liabilities) by type of instrument, stated fair value and maturity date. 12/31/2019 Over 720 Fair value % 0-30 31-90 91-180 181-365 366-720 days Assets Swaps – adjustment receivable 26,458 63.2 107 1,807 564 1,668 4,464 17,848 Option agreements 8,456 20.2 4,696 1,963 354 726 500 217 Forwards (onshore) 2,162 5.2 940 636 484 87 15—Credit derivatives 167 0.4 — 5 3 23 136 NDF—Non Deliverable Forward 4,446 10.6 1,251 1,314 787 561 347 186 Other Derivative Financial Instruments 165 0.4 4 ——6 155 Total 41,854 100.0 6,998 5,720 2,194 3,045 5,355 18,542 % per maturity date 16.7 13.7 5.2 7.3 12.8 44.3 12/31/2019 Over 720 Fair value % 0-30 31-90 91-180 181-365 366-720 days Liabilities Swaps – adjustment payable (32,927) 68.8 (326) (2,557) (898) (1,763) (8,349) (19,034) Option agreements (9,061) 18.9 (3,668) (3,494) (383) (690) (571) (255) Forwards (onshore) (754) 1.6 (753) — (1) — Credit derivatives (40) 0.1 ——(1) (3) (36) NDF—Non Deliverable Forward (4,971) 10.4 (1,891) (1,108) (657) (637) (526) (152) Other Derivative Financial Instruments (75) 0.2 (15) (1) (2) (4) (9) (44) Total (47,828) 100.0 (6,653) (7,160) (1,940) (3,096) (9,458) (19,521) % per maturity date 13.9 15.0 4.1 6.5 19.7 40.8 Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 53

II—Derivatives by index and Risk Fator Balance sheet account Adjustment to fair value Off-balance sheet receivable / (received) (in income / stockholders’ Fair value notional amount (payable) / paid equity) 12/31/2020 12/31/2020 12/31/2020 12/31/2020 Future contracts 781,453 — -Purchase commitments 338,165 ——Shares 8,300 — -Commodities 1,170 — -Interest 304,454 — -Foreign currency 24,241 ——Commitments to sell 443,288 ——Shares 7,535 — -Commodities 2,201 — -Interest 397,157 — -Foreign currency 36,395 ——Swap contracts (6,054) 284 (5,770) Asset position 1,442,449 16,840 29,179 46,019 Commodities 278 1—1 Interest 1,423,134 14,030 27,953 41,983 Foreign currency 19,037 2,809 1,226 4,035 Liability position 1,442,449 (22,894) (28,895) (51,789) Shares 108 (12) 2 (10) Commodities 341 (9)—(9) Interest 1,425,904 (19,112) (28,584) (47,696) Foreign currency 16,096 (3,761) (313) (4,074) Option contracts 1,738,849 22 134 156 Purchase commitments – long position 131,134 14,538 1,828 16,366 Shares 12,400 345 976 1,321 Commodities 356 14 13 27 Interest 50,771 614 (282) 332 Foreign currency 67,607 13,565 1,121 14,686 Commitments to sell – long position 743,573 2,933 1,119 4,052 Shares 14,659 728 62 790 Commodities 75 2 (1) 1 Interest 659,826 1,087 1,373 2,460 Foreign currency 69,013 1,116 (315) 801 Purchase commitments – short position 129,150 (13,934) (1,797) (15,731) Shares 13,080 (348) (1,119) (1,467) Commodities 899 (28) (18) (46) Interest 55,369 (532) 318 (214) Foreign currency 59,802 (13,026) (978) (14,004) Commitments to sell – short position 734,992 (3,515) (1,016) (4,531) Shares 13,200 (524) (156) (680) Commodities 246 (10) 6 (4) Interest 653,376 (978) (1,317) (2,295) Foreign currency 68,170 (2,003) 451 (1,552) Forward operations (onshore) 23,989 1,195 (15) 1,180 Purchases receivable 18,666 1,014 (3) 1,011 Shares 304 304 (3) 301 Interest 584 710—710 Foreign currency 17,778 ——Purchases payable obligations—(584)—(584) Interest—(584)—(584) Sales receivable 1,132 1,073 1 1,074 Shares 770 765 1 766 Interest—308—308 Foreign currency 362 ——Sales deliverable obligations 4,191 (308) (13) (321) Interest 308 (308)—(308) Foreign currency 3,883—(13) (13) Credit derivatives 20,060 (432) 512 80 Asset position 15,877 (270) 426 156 Shares 2,796 (84) 172 88 Commodities 19—1 1 Interest 13,062 (186) 253 67 Liability position 4,183 (162) 86 (76) Shares 1,154 (45) 11 (34) Commodities 3 — -Interest 3,026 (117) 75 (42) NDF—Non Deliverable Forward 313,463 1,214 (44) 1,170 Asset position 156,542 7,467 129 7,596 Commodities 1,715 278 (16) 262 Foreign currency 154,827 7,189 145 7,334 Liability position 156,921 (6,253) (173) (6,426) Commodities 975 (37) (1) (38) Foreign currency 155,946 (6,216) (172) (6,388) Other derivative financial instruments 6,413 181 2 183 Asset position 5,274 196 34 230 Shares 47 (3) 3 -Interest 5,225 199 (26) 173 Foreign currency 2—57 57 Liability position 1,139 (15) (32) (47) Shares 705 (6) (22) (28) Interest 434 (9) (10) (19) Asset 43,791 32,713 76,504 Liability (47,665) (31,840) (79,505) Total (3,874) 873 (3,001) Derivative contracts mature as follows (in days): Off-balance sheet – notional amount 0—30 31—180 181—365 Over 365 days 12/31/2020 Future contracts 305,076 242,842 108,338 125,197 781,453 Swap contracts 272,932 123,360 118,617 927,540 1,442,449 Option contracts 1,012,965 216,425 250,966 258,493 1,738,849 Forwards (onshore) 19,013 3,999 972 5 23,989 Credit derivatives—8,515 804 10,741 20,060 NDF—Non Deliverable Forward 131,205 124,470 38,006 19,782 313,463 Other derivative financial instruments 15 709 279 5,410 6,413 Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 54

Balance sheet account Adjustment to fair value Off-balance sheet receivable / (received) (in income / Fair value notional amount (payable) / paid stockholders’ equity) 12/31/2019 12/31/2019 12/31/2019 12/31/2019 Future contracts 664,884 — -Purchase commitments 325,468 — -Shares 1,084 — -Commodities 76 — -Interest 301,898 — -Foreign currency 22,410 — -Commitments to sell 339,416 — -Shares 1,163 — -Commodities 1,049 — -Interest 308,824 — -Foreign currency 28,380 — -Swap contracts (5,267) (1,202) (6,469) Asset position 1,094,378 5,566 20,892 26,458 Commodities 574—9 9 Interest 1,075,534 4,596 19,813 24,409 Foreign currency 18,270 970 1,070 2,040 Liability position 1,094,378 (10,833) (22,094) (32,927) Shares 49 (9)—(9) Commodities 855—(12) (12) Interest 1,068,660 (9,383) (21,855) (31,238) Foreign currency 24,814 (1,441) (227) (1,668) Option contracts 1,720,205 (546) (59) (605) Purchase commitments – long position 245,824 6,191 (6) 6,185 Shares 11,513 256 515 771 Commodities 268 7 10 17 Interest 188,110 465 (331) 134 Foreign currency 45,933 5,463 (200) 5,263 Commitments to sell – long position 626,187 1,667 604 2,271 Shares 12,294 396 (40) 356 Commodities 228 5 (2) 3 Interest 568,442 513 887 1,400 Foreign currency 45,223 753 (241) 512 Purchase commitments – short position 172,703 (6,671) (19) (6,690) Shares 6,312 (180) (451) (631) Commodities 235 (10) (8) (18) Interest 129,647 (412) 329 (83) Foreign currency 36,509 (6,069) 111 (5,958) Commitments to sell – short position 675,491 (1,733) (638) (2,371) Shares 11,152 (269) (37) (306) Commodities 485 (11)—(11) Interest 621,405 (428) (888) (1,316) Foreign currency 42,449 (1,025) 287 (738) Forward operations (onshore) 5,134 1,412 (4) 1,408 Purchases receivable 668 796 (6) 790 Shares 488 488 (6) 482 Interest 160 308—308 Foreign currency 20 ——Purchases payable obligations 660 (160)—(160) Interest—(160)—(160) Foreign currency 660 ——Sales receivable 1,653 1,368 4 1,372 Shares 786 776 3 779 Interest—592 1 593 Foreign currency 867 ——Sales deliverable obligations 2,153 (592) (2) (594) Interest 592 (592) (1) (593) Foreign currency 1,561—(1) (1) Credit derivatives 12,739 (236) 363 127 Asset position 9,878 (165) 332 167 Shares 2,307 (81) 215 134 Commodities 27 (1) 3 2 Interest 7,423 (87) 114 27 Foreign currency 121 4—4 Liability position 2,861 (71) 31 (40) Shares 719 (28) 8 (20) Commodities 2 — -Interest 2,140 (43) 23 (20) NDF—Non Deliverable Forward 295,508 (552) 27 (525) Asset position 138,772 4,239 207 4,446 Commodities 570 34 (1) 33 Foreign currency 138,202 4,205 208 4,413 Liability position 156,736 (4,791) (180) (4,971) Commodities 316 (10) (1) (11) Foreign currency 156,420 (4,781) (179) (4,960) Other derivative financial instruments 6,581 216 (126) 90 Asset position 5,428 226 (61) 165 Interest 5,428 226 (65) 161 Foreign currency — 4 4 Liability position 1,153 (10) (65) (75) Shares 695 2 (41) (39) Interest 458 (12) (6) (18) Foreign currency — (18) (18) Asset 19,888 21,966 41,854 Liability (24,861) (22,967) (47,828) Total (4,973) (1,001) (5,974) Derivative contracts mature as follows (in days): Off-balance sheet – notional amount 0—30 31—180 181—365 Over 365 days 12/31/2019 Future contracts 196,055 238,485 87,747 142,597 664,884 Swap contracts 24,094 204,065 103,013 763,206 1,094,378 Option contracts 988,793 320,300 258,488 152,624 1,720,205 Forwards (onshore) 953 2,514 1,651 16 5,134 Credit derivatives—4,746 733 7,260 12,739 NDF—Non Deliverable Forward 105,809 129,278 38,851 21,570 295,508 Other derivative financial instruments 12 786 320 5,463 6,581 Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 55

III—Derivatives by notional amount See below the composition of the Derivative Financial Instruments portfolio by type of instrument, stated at their notional amounts, per trading location (organized or over-the-counter market) and counterparties. 12/31/2020 NDF—Non Other derivative Future Option Forwards Swap contracts Credit derivatives Deliverable financial contracts contracts (onshore) Forward instruments Stock exchange 781,453 835,744 1,617,643 23,097 3,743 67,887 -Over-the-counter market—606,705 121,206 892 16,317 245,576 6,413 Financial institutions—531,303 84,865 892 16,317 124,124 5,140 Companies—69,337 35,021 — 120,476 1,273 Individuals—6,065 1,320 — 976—Total 781,453 1,442,449 1,738,849 23,989 20,060 313,463 6,413 12/31/2019 NDF—Non Other derivative Future Option Forwards Swap contracts Credit derivatives Deliverable financial contracts contracts (onshore) Forward instruments Stock exchange 664,884 595,221 1,624,988 4,381 61 69,463 -Over-the-counter market—499,157 95,217 753 12,678 226,045 6,581 Financial institutions—398,585 66,291 292 12,678 125,550 5,340 Companies—69,185 28,511 461—99,151 1,241 Individuals—31,387 415 — 1,344—Total 664,884 1,094,378 1,720,205 5,134 12,739 295,508 6,581 Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 56

IV—Credit derivatives ITAÚ UNIBANCO HOLDING buys and sells credit protection in order to meet the needs of its customers, management and mitigation of its portfolios’ risk. CDS (credit default swap) is a credit derivative in which, upon a default related to the reference entity, the protection buyer is entitled to receive, the amount equivalent to the difference between the face value of the CDS contract and the fair value of the liability on the date the contract was settled, also known as the recovered amount. The protection buyer does not need to hold the debt instrument of the reference entity for it to receive the amounts due pursuant to the CDS contract terms when a credit event occurs. TRS (total return swap) is a transaction in which a party swaps the total return of an asset or of a basket of assets for regular cash flows, usually interest and a guarantee against capital loss. In a TRS contract, the parties do not transfer the ownership of the assets. 12/31/2020 Maximum potential From 1 to 3 From 3 to 5 of future payments, Up to 1 year Over 5 years years years gross By instrument CDS 8,501 1,181 3,928 3,372 20 TRS 7,854 7,854 ——Total by instrument 16,355 9,035 3,928 3,372 20 By risk rating Investment grade 752 296 372 84 -Below investment grade 15,603 8,739 3,556 3,288 20 Total by risk 16,355 9,035 3,928 3,372 20 By reference entity Brazilian government 12,433 8,255 1,627 2,551 -Governments – abroad 243 66 122 55 -Private entities 3,679 714 2,179 766 20 Total by entity 16,355 9,035 3,928 3,372 20 12/31/2019 Maximum potential From 1 to 3 From 3 to 5 of future payments, Up to 1 year Over 5 years years years gross By instrument CDS 6,283 1,013 2,675 2,539 56 TRS 4,161 4,161 ——Total by instrument 10,444 5,174 2,675 2,539 56 By risk rating Investment grade 1,049 135 602 312 -Below investment grade 9,395 5,039 2,073 2,227 56 Total by risk 10,444 5,174 2,675 2,539 56 By reference entity Brazilian government 7,301 4,921 1,117 1,263 -Governments – abroad 200 34 88 78 -Private entities 2,943 219 1,470 1,198 56 Total by entity 10,444 5,174 2,675 2,539 56 ITAÚ UNIBANCO HOLDING assesses the risk of a credit derivative based on the credit ratings attributed to the reference entity by independent credit rating agencies. Investment grade entities are those for which credit risk is rated as Baa3 or higher, as rated by Moody’s, and BBB- or higher, by Standard & Poor’s and Fitch Ratings. The following table presents the notional amount of credit derivatives purchased. The underlying amounts are identical to those for which ITAÚ UNIBANCO HOLDING has sold credit protection. Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 57

12/31/2020 Notional amount of credit protection Notional amount of credit purchased with identical underlying Net position protection sold amount CDS (8,501) 3,705 (4,796) TRS (7,854)—(7,854) Total (16,355) 3,705 (12,650) 12/31/2019 Notional amount of credit protection Notional amount of credit purchased with identical underlying Net position protection sold amount CDS (6,283) 2,295 (3,988) TRS (4,161)—(4,161) Total (10,444) 2,295 (8,149) Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 58

V—Financial instruments subject to offsetting, enforceable master netting arrangements and similar agreements The following tables set forth the financial assets and liabilities that are subject to offsetting, enforceable master netting arrangements and similar agreements, as well as how these financial assets and liabilities have been presented in ITAÚ UNIBANCO HOLDING’s consolidated financial statements. These tables also reflect the amounts of collateral pledged or received in relation to financial assets and liabilities subject to enforceable arrangements that have not been presented on a net basis in accordance with IAS 32. Financial assets subject to offsetting, enforceable master netting arrangements and similar agreements: 12/31/2020 Gross amount of Net amount of financial Related amounts not offset in the Balance Sheet (2) Gross amount offset in recognized financial assets presented in the Total (1) the Balance Sheet assets Balance Sheet Financial instruments (3) Cash collateral received Securities purchased under agreements to resell 239,935—239,935 (1,657)—238,278 Derivatives financial instruments 76,504—76,504 (15,621)—60,883 12/31/2019 Gross amount of Net amount of financial Related amounts not offset in the Balance Sheet (2) Gross amount offset in recognized financial assets presented in the Total (1) the Balance Sheet assets Balance Sheet Financial instruments (3) Cash collateral received Securities purchased under agreements to resell 198,422—198,422 (596)—197,826 Derivatives financial instruments 41,854—41,854 (14,121)—27,733 Financial liabilities subject to offsetting, enforceable master netting arrangements and similar agreements: 12/31/2020 Gross amount of Net amount of financial Related amounts not offset in the Balance Sheet (2) Gross amount offset in recognized financial liabilities presented in the Total (1) the Balance Sheet liabilities Balance Sheet Financial instruments (3) Cash collateral pledged Securities sold under repurchase agreements 273,364—273,364 (42,161)—231,203 Derivatives financial instruments 79,505—79,505 (15,621) (574) 63,310 12/31/2019 Gross amount of Net amount of financial Related amounts not offset in the Balance Sheet (2) Gross amount offset in recognized financial liabilities presented in the Total (1) the Balance Sheet liabilities Balance Sheet Financial instruments (3) Cash collateral pledged Securities sold under repurchase agreements 256,583—256,583 (23,509)—233,074 Derivatives financial instruments 47,828—47,828 (14,121) (148) 33,559 (1) Includes amounts of master offset agreements and other such agreements, both enforceable and unenforceable. (2) Limited to amounts subject to enforceable master offset agreements and other such agreements. (3) Includes amounts subject to enforceable master offset agreements and other such agreements, and guarantees in financial instruments. Financial assets and financial liabilities are offset in the balance sheet only when there is a legally enforceable right to offset the recognized amounts and there is an intention to settle on a net basis, or realize the asset and settle the liability simultaneously. Derivatives financial instruments and repurchased agreements not set off in the balance sheet relate to transactions in which there are enforceable master netting agreements or similar agreements, but the offset criteria have not been met in accordance with paragraph 42 of IAS 32 mainly because ITAÚ UNIBANCO HOLDING has no intention to settle on a net basis, or realize the asset and settle the liability simultaneously. Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 59

Note 7 – Hedge accounting There are three types of hedge relations: Fair value hedge, Cash flow hedge and Hedge of net investment in foreign operations. In hedge accounting, the groups of risk factors measured by ITAÚ UNIBANCO HOLDING are: · Interest Rate: Risk of loss in transactions subject to interest rate variations; · Currency: Risk of loss in transactions subject to foreign exchange variation. The structure of risk limits is extended to the risk factor level, where specific limits aim at improving the monitoring and understanding process, as well as avoiding concentration of these risks. The structures designed for interest rate and exchange rate categories take into account total risk when there are compatible hedging instruments. In certain cases, management may decide to hedge a risk for the risk factor term and limit of the hedging instrument. The other risk factors hedged by the institution are shown in Note 32. To protect cash flows and fair value of instruments designated as hedged items, ITAÚ UNIBANCO HOLDING uses derivative financial instruments and financial assets. Currently, Futures Contracts, Options, NDF (non deliverable forwards), Forwards, Swaps and Financial Assets are used. ITAÚ UNIBANCO HOLDING manages risks through the economic relationship between hedging instruments and hedged items, where the expectation is that these instruments will move in opposite directions and in the same proportion, with the purpose of neutralizing risk factors. The designated coverage ratio is always 100% of the risk factor eligible for coverage. Sources of ineffectiveness are in general related to the counterparty’s credit risk and possible mismatches of terms between the hedging instrument and the hedged item. a) Cash flow hedge The cash flow hedge strategies of ITAÚ UNIBANCO HOLDING consist of hedging exposure to variations in cash flows, in interest payment and currency exposure which are attributable to changes in interest rates on recognized and unrecognized assets and liabilities. ITAÚ UNIBANCO HOLDING applies cash flow hedge strategies as follows: Interest rate risks: · Hedge of time deposits and repurchase agreements: to hedge fluctuations in cash flows of interest payments resulting from changes in the DI interest rate, through futures contracts; · Hedge of asset transactions: to hedge fluctuations in cash flows of interest receipts resulting from changes in the DI rate, through futures contracts; · Hedge of assets denominated in UF*: to hedge fluctuations in cash flows of interest receipts resulting from changes in the UF*, through swap contracts; · Hedge of Funding: to hedge fluctuations in cash flows of interest payments resulting from changes in the TPM* rate, through swap contracts; · Hedge of loan operations: to hedge fluctuations in cash flows of interest receipts resulting from changes in the TPM* rate, through swap contracts; · Hedge of repurchase agreements: to hedge fluctuations in cash flows of interest received from changes in Selic (benchmark interest rate), through futures contracts; · Hedging of expected highly probable transactions: to hedge the risk of variation in the amount of the commitments assumed when resulting from variation in the exchange rates. *UF – Chilean unit of account / TPM – Monetary policy rate ITAÚ UNIBANCO HOLDING does not use the qualitative method to evaluate the effectiveness or to measure the ineffectiveness of these strategies. For cash flow hedge strategies, ITAÚ UNIBANCO HOLDING uses the hypothetical derivative method. This method is based on a comparison of the change in the fair value of a hypothetical derivative with terms identical to the critical terms of the variable-rate liability, and this change in the fair value is considered a proxy of the present value of the cumulative change in the future cash flow expected for the hedged liability. Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 60

12/31/2020 Hedged item Hedge instrument Book Value Variation in fair Strategies Heading Variation in value Cash flow Notional value used to recognized in Other hedge Assets Liabilities Amount calculate hedge comprehensive income reserve ineffectiveness Interest rate risk Securities purchased under Hedge of deposits and repurchase agreements—103,407 (2,423) (2,458) 103,407 (2,429) agreements to resell Loans and lease operations and Hedge of assets transactions 5,673—66 66 5,743 66 Securities Securities purchased under Hedge of asset-backed securities under repurchase agreements 29,533—697 697 31,417 699 agreements to resell Hedge of loan operations Loans and lease operations 327—12 12 316 15 Hedge of funding Deposits—2,007 (10) (10) 1,996 (11) Hedge of assets denominated in UF Securities 16,674—(4) (4) 16,677 (1) Foreign exchange risk Hedge of highly probable forecast transactions 1,314—(105) 148 1,314 (105) Total 53,521 105,414 (1,767) (1,549) 160,870 (1,766) 12/31/2019 Hedged item Hedge instrument Book Value Variation in fair Strategies Heading Variation in value Cash flow Notional value used to recognized in Other hedge Assets Liabilities Amount calculate hedge comprehensive income reserve ineffectiveness Interest rate risk Securities purchased under Hedge of deposits and repurchase agreements—24,543 (2,808) (3,310) 24,543 (2,814) agreements to resell Loans and lease operations and Hedge of assets transactions 5,564—91 91 5,656 91 Securities Securities purchased under Hedge of asset-backed securities under repurchase agreements 30,896—520 520 32,130 523 agreements to resell Hedge of loan operations Loans and lease operations 269—12 12 257 14 Hedge of funding Deposits—4,617 (27) (22) 4,590 (27) Hedge of assets denominated in UF Securities 12,588—6 6 12,582 5 Foreign exchange risk Hedge of highly probable forecast transactions 294—(11) 179 294 (11) Total 49,611 29,160 (2,217) (2,524) 80,052 (2,219) For strategies of deposits and repurchase agreements to resell, asset transactions and asset-backed securities under repurchase agreements, the entity frequently reestablishes the coverage ratio, since both the hedged item and the instruments change over time. This occurs because they are portfolio strategies that reflect the risk management strategy guidelines approved in the proper authority level. The remaining balance in the reserve of cash flow hedge for which the hedge accounting is no longer applied is R$ 218 (R$ (307) at 12/31/2019). 12/31/2020 Book Value (*) Variations in fair Variation in value Hedge ineffecti- Amount Hedge Instruments Notional value used to recognized in Other veness reclassified from amount calculate hedge comprehensive recognized in Cash flow hedge Assets Liabilities ineffectiveness income income reserve to income Interest rate risk Futures 140,567 146—(1,664) (1,660) (4) (381) Swap 18,989 2,007 17,006 3 (2) 5—Foreign exchange risk Futures 1,314 5 298 (105) (105) — Total 160,870 2,158 17,304 (1,766) (1,767) 1 (381) 12/31/2019 (*) Variations in fair Variation in value Hedge ineffecti- Amount Book Value Hedge Instruments Notional value used to recognized in Other veness reclassified from amount Assets Liabilities calculate hedge comprehensive recognized in Cash flow hedge ineffectiveness income income reserve to income Interest rate risk Futures 62,329—14 (2,200) (2,197) (3) (762) Swap 17,429 4,617 12,858 (8) (9) 1—Foreign exchange risk Futures 294—156 (11) (11) — Total 80,052 4,617 13,028 (2,219) (2,217) (2) (762) (*) Amounts recorded under heading Derivatives. Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 61

b) Hedge of net investment in foreign operations ITAÚ UNIBANCO HOLDING’s strategies for net investments in foreign operations consist of hedging the exposure in the functional currency of the foreign operation against the functional currency of head office. The risk hedged in this type of strategy is the currency risk. ITAÚ UNIBANCO HOLDING does not use the qualitative method to evaluate the effectiveness or to measure the ineffectiveness of these strategies. Instead, ITAÚ UNIBANCO HOLDING uses the Dollar Offset Method, which is based on a comparison of the change in fair value (cash flow) of the hedging instrument, attributable to changes in the exchange rate and the gain (loss) arising from variations in exchange rates on the amount of investment abroad designated as the object of the hedge. 12/31/2020 Hedged item Hedge instrument Strategies Book Value (2) Variation in value Variation in fair value Foreign currency Notional used to calculate recognized in Other convertion reserve amount hedge Assets Liabilities comprehensive income ineffectiveness Foreign exchange risk Hedge of net investment in foreign operations (1) 15,277—(14,598) (14,598) 24,619 (14,601) Total 15,277—(14,598) (14,598) 24,619 (14,601) 12/31/2019 Hedged item Hedge instrument Strategies Book Value (2) Variation in value Variation in fair value Foreign currency Notional used to calculate recognized in Other convertion reserve amount hedge Assets Liabilities comprehensive income ineffectiveness Foreign exchange risk Hedge of net investment in foreign operations (1) 14,396—(7,217) (7,217) 16,947 (7,220) Total 14,396—(7,217) (7,217) 16,947 (7,220) (1) Hedge instruments consider the gross tax position. (2) Amounts recorded under heading Derivatives—Hedge of investments in foreign operation. 12/31/2020 Book Value (*) Variations in fair Variation in the value Hedge Amount reclassified Hedge instruments Notional value used to recognized in Other ineffectiveness from foreign currency amount Assets Liabilities calculate hedge comprehensive recognized in convertion reserve ineffectiveness income income into income Foreign exchange risk Futures 44,186—150 (18,732) (18,695) (37)—Forward (4,262) 4,474—332 305 27—NDF—Non Deliverable Forward (15,196) 538—3,556 3,547 9—Financial Assets (109) 109—243 245 (2)—Total 24,619 5,121 150 (14,601) (14,598) (3)—12/31/2019 (*) Variations in fair Variation in the value Hedge Amount reclassified Book Value Hedge instruments Notional value used to recognized in Other ineffectiveness from foreign currency amount calculate hedge comprehensive recognized in convertion reserve Assets Liabilities ineffectiveness income income into income Foreign exchange risk Futures 32,966 228—(12,329) (12,292) (37)—Forward (2,990) 2,977—408 381 27—NDF—Non Deliverable Forward (11,525) 260—4,443 4,434 9—Financial Assets (1,504) 1,523—258 260 (2)—Total 16,947 4,988—(7,220) (7,217) (3)—(*) Amounts recorded under heading Derivatives. Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 62

c) Fair value hedge The fair value hedging strategy of ITAÚ UNIBANCO HOLDING consists of hedging the exposure to variation in fair value on the receipt and payment of interest on recognized assets and liabilities. ITAÚ UNIBANCO HOLDING applies fair value hedges as follows: Interest rate risk: · To protect the risk of variation in the fair value of receipt and payment of interest resulting from variations in the fair value of the variable rates involved, by contracting swaps and futures. ITAÚ UNIBANCO HOLDING does not use the qualitative method to evaluate the effectiveness or to measure the ineffectiveness of these strategies. Instead, ITAÚ UNIBANCO HOLDING uses the percentage approach and dollar offset method: · The percentage approach is based on the calculation of change in the fair value of the revised estimate for the hedged position (hedged item) attributable to the protected risk versus the change in the fair value of the derivative hedging instrument. · The dollar offset method is based on the difference between the variation in the fair value of the hedging instrument and the variation in the fair value of the hedged item attributed to changes in the interest rate. The effects of hedge accounting on the financial position and performance of ITAÚ UNIBANCO HOLDING are presented below: 12/31/2020 Hedge Item Hedge Instruments (2) Book Value (1) Fair value Variation in fair Strategies Variation in fair value Notional value used to recognized in amount calculate hedge Assets Liabilities Assets Liabilities income ineffectiveness Interest rate risk Hedge of loan operations 9,205—9,616—411 9,205 (423) Hedge of funding—10,200—11,591 (1,391) 10,200 1,390 Hedge of securities at fair value through other 10,192—10,412—220 10,383 (226) comprehensive income Total 19,397 10,200 20,028 11,591 (760) 29,788 741 12/31/2019 Hedge Item Hedge Instruments Book Value (1) Fair value Variation in fair Strategies Variation in fair value Notional value used to recognized in amount calculate hedge Assets Liabilities Assets Liabilities income ineffectiveness Interest rate risk Hedge of loan operations 7,386—7,642—256 7,386 (264) Hedge of funding—7,436—8,195 (759) 7,436 775 Hedge of securities at fair value through other 4,482—4,574—92 4,609 (85) comprehensive income Total 11,868 7,436 12,216 8,195 (411) 19,431 426 (1) Amounts recorded under heading Deposits, Securities, Funds from Interbank Markets and Loan and Lease Operations. (2) Comprises the amount of R$ 4,915 at 12/31/2020, related to instruments exposed by the change in reference interest rates—IBORs. For loan operations strategies, the entity reestablishes the coverage ratio, since both the hedged item and the instruments change over time. This occurs because they are portfolio strategies that reflect the risk management strategy guidelines approved in the proper authority level. Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 63

12/31/2020 Book value (1) Variation in fair value used Hedge Instruments Notional to calculate hedge Hedge ineffectiveness amount Assets Liabilities recognized in income ineffectiveness Interest rate risk Swap (2) 29,788 2,871 5,812 741 (19) Total 29,788 2,871 5,812 741 (19) 12/31/2019 Hedge Instruments Notional Book value (1) Variation in fair value used Hedge ineffectiveness to calculate hedge amount Assets Liabilities recognized in income ineffectiveness Interest rate risk Swap (2) 19,431 766 4,636 426 15 Total 19,431 766 4,636 426 15 (1) Amounts recorded under heading Derivatives. (2) The amount of R$ 183 is no longer qualified as hedge, with effect on result of R$ (17) (R$ 408 at 12/31/2019, with effect on result of R$ (15) from 01/01 to 12/31/2019). Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 64

The table below presents, for each strategy, the notional amount and the fair value adjustments of hedge instruments and the book value of the hedged item: 12/31/2020 12/31/2019 Strategies Hedge instruments Hedged item Hedge instruments Hedged item Fair value Notional Fair value Notional amount Book Value Book Value adjustments amount adjustments Hedge of deposits and repurchase agreements 103,407 158 103,407 24,543 (37) 24,543 Hedge of highly probable forecast transactions 1,314 (105) 1,314 294 (11) 294 Hedge of net investment in foreign operations 24,619 4,971 15,277 16,947 4,988 14,396 Hedge of loan operations (Fair value) 9,205 (423) 9,205 7,386 (264) 7,386 Hedge of loan operations (Cash flow) 316 15 327 257 14 269 Hedge of funding (Fair value) 10,200 1,390 10,200 7,436 775 7,436 Hedge of funding (Cash flow) 1,996 (11) 2,007 4,590 (27) 4,617 Hedge of assets transactions 5,743 66 5,673 5,656 91 5,564 Hedge of asset-backed securities under repurchase agreements 31,417 (11) 29,533 32,130 20 30,896 Hedge of assets denominated in UF 16,677 (1) 16,674 12,582 5 12,588 Hedge of securities at fair value through other comprehensive income 10,383 (226) 10,192 4,609 (85) 4,482 Total 5,823 5,469 The table below shows the breakdown by maturity of the hedging strategies: 12/31/2020 0-1 year 1-2 years 2-3 years 3-4 years 4-5 years 5-10 years over 10 years Total Hedge of deposits and repurchase agreements 70,200 9,077 13,059 5,504 4,848 719—103,407 Hedge of highly probable forecast transactions 1,314 — — — 1,314 Hedge of net investment in foreign operations (*) 24,619 — — — 24,619 Hedge of loan operations (Fair value) 2,999 1,793 1,297 447 898 1,771—9,205 Hedge of loan operations (Cash flow) 212 104 — ——316 Hedge of funding (Fair value) 213 657 549 176 581 5,448 2,576 10,200 Hedge of funding (Cash flow) 1,765 27 204 — — 1,996 Hedge of assets transactions 3,604 2,139 — ——5,743 Hedge of asset-backed securities under repurchase agreements 22,186 2,297 6,130—804 — 31,417 Hedge of assets denominated in UF 15,400 1,277 — ——16,677 Hedge of securities at fair value through other comprehensive income 5,876 1,382 10—719 2,396—10,383 Total 148,388 18,753 21,249 6,127 7,850 10,334 2,576 215,277 12/31/2019 0-1 year 1-2 years 2-3 years 3-4 years 4-5 years 5-10 years over 10 years Total Hedge of deposits and repurchase agreements 5,533 4,409 1,627 8,464—4,510—24,543 Hedge of highly probable forecast transactions 294 — — — 294 Hedge of net investment in foreign operations (*) 16,947 — — — 16,947 Hedge of loan operations (Fair value) 381 2,490 1,248 993 623 1,111 540 7,386 Hedge of loan operations (Cash flow) 27 156 74 — — 257 Hedge of funding (Fair value) 299 152 375 423 129 4,220 1,838 7,436 Hedge of funding (Cash flow) 2,562 — 1,646 161 221—4,590 Hedge of assets transactions—3,671 1,985 — — 5,656 Hedge of asset-backed securities under repurchase agreements 6,225 18,739 812 5,621—733—32,130 Hedge of assets denominated in UF 9,628 2,954 — ——12,582 Hedge of securities at fair value through other comprehensive income 4,230—28 — 351—4,609 Total 46,126 32,571 6,149 17,147 913 11,146 2,378 116,430 (*) Classified as current, since instruments are frequently renewed. Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 65

Note 8 – Financial assets at fair value through other comprehensive income—Securities The fair value and corresponding gross carrying amount of Financial Assets at Fair Value Through Other Comprehensive Income—Securities assets are as follows: 12/31/2020 12/31/2019 Fair value Fair value Gross Gross adjustments (in Expected adjustments (in Expected carrying Fair value carrying Fair value stockholders’ loss stockholders’ loss amount (2) amount equity) equity) Brazilian government securities (1a) 65,235 2,714—67,949 48,718 2,014—50,732 Other government securities 36—(36)—36—(36) -Government securities – abroad (1b) 34,365 38 (1) 34,402 20,638 (64) (3) 20,571 Germany — — 23 — 23 Colombia 3,913 73—3,986 3,851 27—3,878 Chile 21,639 12—21,651 11,119 89—11,208 United States 3,751 (1)—3,750 2,758 (2)—2,756 Italy — — 328 1—329 Mexico 1,180 1—1,181 — —Paraguay 3,008 (60) (1) 2,947 1,957 (174) (3) 1,780 Uruguay 874 13—887 602 (5)—597 Corporate securities (1c) 7,799 (152) (56) 7,591 5,308 96 (47) 5,357 Shares 1,640 (258)—1,382 83 66—149 Bank deposit certificates 305 2—307 2,371 — 2,371 Securitized real estate loans — — 25 1—26 Debentures 956 (23) (44) 889 387 (10) (43) 334 Eurobonds and other 4,895 127 (9) 5,013 2,439 39 (1) 2,477 Other 3—(3)—3—(3)—Total 107,435 2,600 (93) 109,942 74,700 2,046 (86) 76,660 (1) Financial assets at fair value through other comprehensive income—Securities pledged in guarantee of funding transactions of financial institutions and customers were: a) R$ 35,203 (R$ 27,864 at 12/31/2019), b) R$ 2,398 (R$ 590 at 12/31/2019) and c) R$ 518, totaling R$ 38,119 (R$ 28,454 at 12/31/2019). (2) In the period, the result of Adjustment to Fair Value of Financial Assets (particularly private securities) had their amounts affected by oscillations of rates and other market variables arising from the impact of the COVID-19 pandemic on the macroeconomic scenario in the period (Note 33a). The gross carrying amount and the fair value of financial assets through other comprehensive income—securities by maturity are as follows: 12/31/2020 12/31/2019 Gross Gross carrying Fair value carrying Fair value amount amount Current 33,094 32,872 10,258 10,272 Non-stated maturity 1,640 1,382 83 149 Up to one year 31,454 31,490 10,175 10,123 Non-current 74,341 77,070 64,442 66,388 From one to five years 52,825 54,452 45,704 46,456 From five to ten years 14,084 14,852 11,101 11,649 After ten years 7,432 7,766 7,637 8,283 Total 107,435 109,942 74,700 76,660 Equity instruments at fair value through other comprehensive income—securities are presented in the table below: 12/31/2020 Gross carrying Adjustments to fair value Expected loss Fair Value amount (in Stockholders’ equity) Shares 1,640 (258)—1,382 Total 1,640 (258)—1,382 12/31/2019 Gross carrying Adjustments to fair value Expected loss Fair Value amount (in Stockholders’ equity) Shares 83 66—149 Total 83 66—149 In the period there was no receipt of dividends and there was no reclassification in Stockholders´ Equity. ITAÚ UNIBANCO HOLDING adopted the option of designating equity instruments at fair value through other comprehensive income due to the particularities of a certain market. 12/31/2020 12/31/2019 Gross carrying Gross carrying Fair Value Fair Value amount amount Current 1,640 1,382 83 149 Non-stated maturity 1,640 1,382 83 149 Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 66

Reconciliation of expected loss for Other financial assets, segregated by stages: Expected Expected Gains / Transfer to Transfer to Cure from Cure from Stage 1 loss Purchases Settlements loss (Losses) stage 2 stage 3 stage 2 stage 3 12/31/2019 12/31/2020 Financial assets at fair value through other comprehensive (86) (8) (17) 18 — — (93) income Brazilian government securities (36) — — ——(36) Other (36) — — ——(36) Government securities—abroad (3) 2 (1) 1 — — (1) Corporate securities (47) (10) (16) 17 — — (56) Debentures (43)—(1) — ——(44) Eurobonds and other (1) (10) (15) 17 — — (9) Other (3) — — ——(3) Expected Expected Gains / Transfer to Transfer to Cure from Cure from Stage 1 loss Purchases Settlements loss (Losses) stage 2 stage 3 stage 2 stage 3 12/31/2018 12/31/2019 Financial assets at fair value through other comprehensive (85)—(1) — ——(86) income Brazilian government securities (36) — — ——(36) Other (36) — — ——(36) Government securities—abroad - (2) (1) — — - (3) Corporate securities (49) 2 — — — (47) Debentures (43) — — ——(43) Eurobond and other (3) 2 — — — (1) Other (3) — — ——(3) Note 9—Financial assets at amortized cost—Securities The Financial assets at amortized cost—Securities are as follows: 12/31/2020 12/31/2019 Net Net Amortized Expected Amortized Expected Amortized Amortized Cost Loss Cost Loss (1a) Cost Cost Brazilian government securities 64,568 (44) 64,524 56,355 (52) 56,303 Government securities – abroad 19,095 (14) 19,081 17,226—17,226 Colombia 500—500 335—335 Chile 705 (1) 704 621—621 Korea 3,951 (4) 3,947 3,427—3,427 Spain 4,847 (3) 4,844 4,984—4,984 United States ——80—80 Mexico 9,042 (6) 9,036 7,763—7,763 Uruguay 50—50 16—16 Corporate securities (1b) 46,141 (3,007) 43,134 59,538 (2,601) 56,937 Rural product note 3,499 (25) 3,474 5,388 (47) 5,341 Bank deposit certificates 30—30 54—54 Real estate receivables certificates 4,806 (12) 4,794 5,844 (2) 5,842 Debentures 34,849 (2,952) 31,897 41,053 (2,532) 38,521 Eurobonds and other 209 (1) 208 1,083 (1) 1,082 Promissory notes 2,023 (10) 2,013 5,001 (3) 4,998 Other 725 (7) 718 1,115 (16) 1,099 Total 129,804 (3,065) 126,739 133,119 (2,653) 130,466 (1) Financial Assets at Amortized Cost – Securities Pledged as Collateral of Funding Transactions of Financial Institutions and Customers were: a) R$ 13,786 (R$ 9,583 at 12/31/2019); b) R$ 14,364 (R$ 17,457 at 12/31/2019), totaling R$ 28,150 (R$ 27,040 at 12/31/2019). The amortized cost of Financial assets at amortized cost—Securities by maturity is as follows: 12/31/2020 12/31/2019 Net Amortized Net Amortized Amortized Cost Amortized Cost Cost Cost Current 38,285 37,672 30,113 29,766 Up to one year 38,285 37,672 30,113 29,766 Non-current 91,519 89,067 103,006 100,700 From one to five years 56,447 55,070 57,120 56,178 From five to ten years 24,434 23,697 34,599 33,512 After ten years 10,638 10,300 11,287 11,010 Total 129,804 126,739 133,119 130,466 Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 67

Reconciliation of expected loss to financial assets at amortized cost—securities, segregated by stages: Expected Expected Gains / Transfer to Transfer to Cure from Cure from Stage 1 loss Purchases Settlements loss (Losses) Stage 2 Stage 3 Stage 2 Stage 3 12/31/2019 12/31/2020 Financial assets at amortized cost (198) (113) (172) 311 21 — (34) (185) Brazilian government securities (52) 8 — — — (44) Government securities—abroad—8 (34) 12 — — (14) Chile - (1) — — — (1) Colombia -—(2) 2 - — — Korea - 7 (14) 3 - ——(4) Spain -—(3) - - ——(3) Mexico - 2 (15) 7 - ——(6) Corporate securities (146) (129) (138) 299 21 — (34) (127) Rural product note (9) 15 (44) 15 — — (23) Real estate receivables certificates (2) (10) (9) 13 — — (8) Debentures (131) (124) (60) 250 21 — (34) (78) Eurobond and other (1) (6) (2) 8 — — (1) Promissory notes (3) (7) (10) 10 — — (10) Other—3 (13) 3 — — (7) Expected Expected Gains / Transfer to Transfer to Cure from Cure from Stage 2 loss Purchases Settlements loss (Losses) Stage 1 Stage 3 Stage 1 Stage 3 12/31/2019 12/31/2020 Financial assets at amortized cost (58) (9) (67) 61—54 (21) (13) (53) Corporate securities (58) (9) (67) 61—54 (21) (13) (53) Rural product note (5) (3)—5—1 — (2) Real estate receivables certificates—(4) — — — (4) Debentures (53) (1) (67) 55—53 (21) (13) (47) Eurobond and other—(1)—1 — ——Expected Expected Gains / Transfer to Transfer to Cure from Cure from Stage 3 loss Purchases Settlements loss (Losses) Stage 1 Stage 2 Stage 1 Stage 2 12/31/2019 12/31/2020 Financial assets at amortized cost (2,397) (1,278) (238) 1,093 34 13—(54) (2,827) Corporate securities (2,397) (1,278) (238) 1,093 34 13—(54) (2,827) Rural product note (33) (7) (1) 42 ——(1)—Debentures (2,348) (1,287) (207) 1,021 34 13—(53) (2,827) Other (16) 16 (30) 30 — ——Expected Expected Gains / Transfer to Transfer to Cure from Cure from Stage 1 loss Purchases Settlements loss (Losses) Stage 2 Stage 3 Stage 2 Stage 3 12/31/2018 12/31/2019 Financial assets at amortized cost (223) 36 (38) 48 74—(75) (20) (198) Brazilian government securities - 7 — — (59)—(52) Government securities—abroad—Colombia (4) 5 (3) 2 - — - -Corporate securities (219) 24 (35) 46 74—(16) (20) (146) Rural product note (7) 4 (7) 1 — — (9) Real estate receivables certificates (2)—(4) 23 ——(19) (2) Debentures (206) 19 (21) 20 74—(16) (1) (131) Eurobond and other (2) — 1 — — (1) Promissory notes (2) 1 (3) 1 — — (3) Expected Expected Gains / Transfer to Transfer to Cure from Cure from Stage 2 loss Purchases Settlements loss (Losses) Stage 1 Stage 3 Stage 1 Stage 3 12/31/2018 12/31/2019 Financial assets at amortized cost (824) 82 (2) 66 75 619 (74)—(58) Brazilian government securities (59) ——59 — —Corporate securities (765) 82 (2) 66 16 619 (74)—(58) Rural product note—(8) (2) — 5 — (5) Debentures (765) 90—66 16 614 (74)—(53) Expected Expected Gains / Transfer to Transfer to Cure from Cure from Stage 3 loss Purchases Settlements loss (Losses) Stage 1 Stage 2 Stage 1 Stage 2 12/31/2018 12/31/2019 Financial assets at amortized cost (2,599) (35) (193) 1,029 20 — (619) (2,397) Corporate securities (2,599) (35) (193) 1,029 20 — (619) (2,397) Rural product note (173) (3) (50) 198 ——(5) (33) Real estate receivables certificates (361) 16—326 19 — — Debentures (2,037) (48) (127) 477 1 — (614) (2,348) Promissory notes (11) — 11 — ——Other (17)—(16) 17 — — (16) Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 68

Note 10—Loan and lease operations a) Composition of loans and lease operations portfolio Below is the composition of the carrying amount of loan operations and lease operations by type, sector of debtor, maturity and concentration: Loans and lease operations by type 12/31/2020 12/31/2019 Individuals 255,483 240,490 Credit card 87,073 91,676 Personal loan 35,346 34,892 Payroll loans 55,508 49,608 Vehicles 23,290 18,968 Mortgage loans 54,266 45,346 Corporate 134,521 100,789 Micro / small and medium companies 121,955 90,733 Foreign loans—Latin America 202,145 153,779 Total loans and lease operations 714,104 585,791 Provision for Expected Loss (1) (48,322) (37,508) Total loans and lease operations, net of Expected Credit Loss 665,782 548,283 (1) Comprises Expected Credit Loss for Financial Guarantees Pledged R$ (907) (R$ (837) at 12/31/2019) and Commitments to be Released R$ (3,485) (R$ (3,303) at 12/31/2019). By maturity 12/31/2020 12/31/2019 Overdue as from 1 day 18,683 21,263 Falling due up to 3 months 172,497 165,028 Falling due from 3 months to 12 months 181,033 149,388 Falling due after 1 year 341,891 250,112 Total loans and lease operations 714,104 585,791 By concentration 12/31/2020 12/31/2019 Largest debtor 7,243 5,389 10 largest debtors 37,863 29,340 20 largest debtors 54,812 44,712 50 largest debtors 83,438 71,965 100 largest debtors 112,333 97,695 The breakdown of the loans and lease operations portfolio by debtor’s industry is described in Note 32, item 1.4.1—By business sector. Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 69

b) Gross Carrying Amount (Loan Portfolio) Reconciliation of gross portfolio of loans and lease operations, segregated by stages: Balance at Transfer to Transfer to Cure from the Cure from the Acquisition / Closing balance Stage 1 Derecognition 12/31/2019 Stage 2 Stage 3 (*) Stage 2 Stage 3 (Settlement) 12/31/2020 Individuals 199,907 (32,363) (1,779) 10,186 38—23,169 199,158 Corporate 91,448 (2,822) (82) 996 299—33,826 123,665 Micro / Small and medium companies 77,722 (14,370) (1,501) 4,827 875—29,231 96,784 Foreign loans—Latin America 132,812 (12,793) (2,456) 3,229 47—46,762 167,601 Total 501,889 (62,348) (5,818) 19,238 1,259—132,988 587,208 Balance at Transfer to Transfer to Cure from the Cure from the Acquisition / Closing balance Stage 2 Derecognition 12/31/2019 Stage 1 Stage 3 Stage 1 Stage 3 (Settlement) 12/31/2020 Individuals 19,070 (10,186) (7,158) 32,363 964—(4,260) 30,793 Corporate 911 (996) (370) 2,822 51—375 2,793 Micro / Small and medium companies 7,225 (4,827) (2,193) 14,370 483—907 15,965 Foreign loans—Latin America 14,714 (3,229) (11,998) 12,793 834—3,578 16,692 Total 41,920 (19,238) (21,719) 62,348 2,332—600 66,243 Balance at Transfer to Transfer to Cure from the Cure from the Acquisition / Closing balance Stage 3 Derecognition 12/31/2019 Stage 1 Stage 2 Stage 1 Stage 2 (Settlement) 12/31/2020 Individuals 21,513 (38) (964) 1,779 7,158 (11,764) 7,848 25,532 Corporate 8,430 (299) (51) 82 370 570 (1,039) 8,063 Micro / Small and medium companies 5,786 (875) (483) 1,501 2,193 (1,836) 2,920 9,206 Foreign loans—Latin America 6,253 (47) (834) 2,456 11,998 (608) (1,366) 17,852 Total 41,982 (1,259) (2,332) 5,818 21,719 (13,638) 8,363 60,653 Balance at Acquisition / Closing balance Consolidated 3 Stages Derecognition 12/31/2019 (Settlement) 12/31/2020 Individuals 240,490 (11,764) 26,757 255,483 Corporate 100,789 570 33,162 134,521 Micro / Small and medium companies 90,733 (1,836) 33,058 121,955 Foreign loans—Latin America 153,779 (608) 48,974 202,145 Total 585,791 (13,638) 141,951 714,104 (*) In the movement of transfer of operations from stage 1 to stage 3 over the period, a representative part thereof have first gone through stage 2. Reconciliation of gross portfolio of loan and lease operations, segregated by stages: Balance at Transfer to Transfer to Cure from Cure from Acquisition / Closing balance Stage 1 Derecognition 12/31/2018 Stage 2 Stage 3 (*) the Stage 2 the Stage 3 (Settlement) 12/31/2019 Individuals 177,488 (19,661) (2,009) 8,680 — 35,409 199,907 Corporate 87,344 (904) (36) 875 8—4,161 91,448 Micro / Small and medium companies 60,471 (5,484) (823) 3,224 44—20,290 77,722 Foreign loans—Latin America 134,323 (12,022) (1,001) 5,029 74—6,409 132,812 Total 459,626 (38,071) (3,869) 17,808 126—66,269 501,889 Balance at Transfer to Transfer to Cure from Cure from Acquisition / Closing balance Stage 2 Derecognition 12/31/2018 Stage 1 Stage 3 the Stage 1 the Stage 3 (Settlement) 12/31/2019 Individuals 17,029 (8,680) (7,579) 19,661 977—(2,338) 19,070 Corporate 2,038 (875) (753) 904 1—(404) 911 Micro / Small and medium companies 6,059 (3,224) (1,841) 5,484 483—264 7,225 Foreign loans—Latin America 11,768 (5,029) (3,335) 12,022 731—(1,443) 14,714 Total 36,894 (17,808) (13,508) 38,071 2,192—(3,921) 41,920 Balance at Transfer to Transfer to Cure from Cure from Acquisition / Closing balance Stage 3 Derecognition 12/31/2018 Stage 1 Stage 2 the Stage 1 the Stage 2 (Settlement) 12/31/2019 Individuals 18,047—(977) 2,009 7,579 (9,710) 4,565 21,513 Corporate 9,674 (8) (1) 36 753 (868) (1,156) 8,430 Micro / Small and medium companies 5,869 (44) (483) 823 1,841 (2,011) (209) 5,786 Foreign loans—Latin America 5,981 (74) (731) 1,001 3,335 (1,710) (1,549) 6,253 Total 39,571 (126) (2,192) 3,869 13,508 (14,299) 1,651 41,982 Balance at Acquisition / Closing balance Consolidated 3 Stages Derecognition 12/31/2018 (Settlement) 12/31/2019 Individuals 212,564 (9,710) 37,636 240,490 Corporate 99,056 (868) 2,601 100,789 Micro / Small and medium companies 72,399 (2,011) 20,345 90,733 Foreign loans—Latin America 152,072 (1,710) 3,417 153,779 Total 536,091 (14,299) 63,999 585,791 (*) In the movement of transfer of operations from stage 1 to stage 3 over the period, a representative part thereof have first gone through stage 2. Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 70

c) Expected credit loss Reconciliation of expected credit loss of loans and lease operations, segregated by stages: Balance at Transfer to Transfer to Cure from the Cure from the (Increase) / Closing balance Stage 1 Derecognition 12/31/2019 Stage 2 Stage 3 (1) Stage 2 Stage 3 Reversal 12/31/2020 Individuals (5,215) 1,541 197 (525) — (1,401) (5,403) Corporate (506) 205 3 (180) (17)—(245) (740) Micro / Small and medium companies (1,092) 698 90 (306) (41)—(622) (1,273) Foreign loans—Latin America (1,353) 275 513 (104) (12)—(1,708) (2,389) Total (8,166) 2,719 803 (1,115) (70)—(3,976) (9,805) Balance at Transfer to Transfer to Cure from the Cure from the (Increase) / Closing balance Stage 2 Derecognition 12/31/2019 Stage 1 Stage 3 Stage 1 Stage 3 Reversal 12/31/2020 Individuals (2,811) 525 2,872 (1,541) (69)—(2,231) (3,255) Corporate (91) 180 63 (205) (9)—(1,199) (1,261) Micro / Small and medium companies (890) 306 550 (698) (92)—(513) (1,337) Foreign loans—Latin America (2,765) 104 2,084 (275) (218)—(959) (2,029) Total (6,557) 1,115 5,569 (2,719) (388)—(4,902) (7,882) Balance at Transfer to Transfer to Cure from the Cure from the (Increase) / Closing balance Stage 3 Derecognition 12/31/2019 Stage 1 Stage 2 Stage 1 Stage 2 Reversal 12/31/2020 Individuals (11,427)—69 (197) (2,872) 11,764 (9,809) (12,472) Corporate (6,288) 17 9 (3) (63) (570) 946 (5,952) Micro / Small and medium companies (2,567) 41 92 (90) (550) 1,836 (2,521) (3,759) Foreign loans—Latin America (2,503) 12 218 (513) (2,084) 608 (4,190) (8,452) Total (22,785) 70 388 (803) (5,569) 13,638 (15,574) (30,635) Balance at (Increase) / Closing balance Consolidated 3 Stages Derecognition 12/31/2019 Reversal (2) at 12/31/2020 (3) Individuals (19,453) 11,764 (13,441) (21,130) Corporate (6,885) (570) (498) (7,953) Micro / Small and medium companies (4,549) 1,836 (3,656) (6,369) Foreign loans—Latin America (6,621) 608 (6,857) (12,870) Total (37,508) 13,638 (24,452) (48,322) (1) In the movement of transfer of operations from stage 1 to stage 3 over the period, a representative part thereof have first gone through stage 2. (2) The increase in the Expected Credit Loss is related to the change in the macroeconomic scenario as from the second half of March 2020 and that impacted our provisioning model for expected loss (Note 33a). (3) Comprises Expected Credit Loss for Financial Guarantees R$ (907) (R$ (837) at 12/31/2019) and Loan Commitments R$ (3,485) (R$ (3,303) at 12/31/2019). Reconciliation of expected credit loss of loans and lease operations, segregated by stages: Closing Balance at Transfer to Transfer to Cure from the Cure from the (Increase) / Stage 1 Derecognition balance 12/31/2018 Stage 2 Stage 3 (1) Stage 2 Stage 3 Reversal 12/31/2019 Individuals (3,892) 846 282 (264) — (2,187) (5,215) Corporate (520) 59 1 (158) — 112 (506) Micro / Small and medium companies (1,123) 225 72 (148) (10)—(108) (1,092) Foreign loans—Latin America (1,396) 258 18 (160) (40)—(33) (1,353) Total (6,931) 1,388 373 (730) (50)—(2,216) (8,166) Closing Balance at Transfer to Transfer to Cure from the Cure from the (Increase) / Stage 2 Derecognition balance 12/31/2018 Stage 1 Stage 3 Stage 1 Stage 3 Reversal 12/31/2019 Individuals (2,116) 264 3,117 (846) (155)—(3,075) (2,811) Corporate (549) 158 245 (59) — 114 (91) Micro / Small and medium companies (603) 148 514 (225) (144)—(580) (890) Foreign loans—Latin America (1,183) 160 562 (258) (268)—(1,778) (2,765) Total (4,451) 730 4,438 (1,388) (567)—(5,319) (6,557) Closing Balance at Transfer to Transfer to Cure from the Cure from the (Increase) / Stage 3 Derecognition balance 12/31/2018 Stage 1 Stage 2 Stage 1 Stage 2 Reversal 12/31/2019 Individuals (8,417)—155 (282) (3,117) 9,710 (9,476) (11,427) Corporate (8,231) — (1) (245) 868 1,321 (6,288) Micro / Small and medium companies (2,873) 10 144 (72) (514) 2,011 (1,273) (2,567) Foreign loans—Latin America (2,606) 40 268 (18) (562) 1,710 (1,335) (2,503) Total (22,127) 50 567 (373) (4,438) 14,299 (10,763) (22,785) Closing Balance at (Increase) / Consolidated 3 Stages Derecognition balance at 12/31/2018 Reversal (2) (3) 12/31/2019 Individuals (14,425) 9,710 (14,738) (19,453) Corporate (9,300) 868 1,547 (6,885) Micro / Small and medium companies (4,599) 2,011 (1,961) (4,549) Foreign loans—Latin America (5,185) 1,710 (3,146) (6,621) Total (33,509) 14,299 (18,298) (37,508) (1) In the movement of transfer of operations from stage 1 to stage 3 over the period, a representative part thereof have first gone through stage 2. (2) Change in macroeconomic scenarios used gave rise, in the fourth quarter, to a reversal of the Provision for Expected Loss in the amount of R$ 8. (3) Comprises expected credit loss for Financial Guarantees R$ (837) (R$ (1,191) at 12/31/2018) and Loan Commitments R$ (3,303) (R$ (2,601) at 12/31/2018). Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 71

0 d) Lease operations—Lessor Finance leases are composed of vehicles, machines, equipment and real estate in Brazil and abroad. The analysis of portfolio maturities is presented below: 12/31/2020 12/31/2019 Payments Future financial Present Payments Future financial Present receivable income value receivable income value Current 2,277 (597) 1,680 1,899 (421) 1,478 Up to 1 year 2,277 (597) 1,680 1,899 (421) 1,478 Non-current 10,553 (2,956) 7,597 8,613 (2,640) 5,973 From 1 to 2 years 1,809 (472) 1,337 1,535 (439) 1,096 From 2 to 3 years 1,424 (398) 1,026 1,223 (368) 855 From 3 to 4 years 1,153 (337) 816 982 (310) 672 From 4 to 5 years 930 (289) 641 1,001 (287) 714 Over 5 years 5,237 (1,460) 3,777 3,872 (1,236) 2,636 Total 12,830 (3,553) 9,277 10,512 (3,061) 7,451 Financial lease revenues are composed of: 01/01 to 01/01 to 12/31/2020 12/31/2019 Financial Income 645 612 Variable payments 40 39 Total 685 651 e) Operations of securitization or transfer and acquisition of financial assets ITAÚ UNIBANCO HOLDING carried out operations of securitization or transfer of financial assets in which there was retention of credit risks of financial assets transferred under co-obligation covenants. Thus, these credits are still recorded in the Consolidated Balance Sheet and are represented as follows: 12/31/2020 12/31/2019 Nature of operation Assets Liabilities (*) Assets Liabilities (*) Book Book Book Book Fair value Fair value Fair value Fair value value value value value Mortgage loan 349 366 347 362 1,305 1,352 1,303 1,349 Working capital 1,297 1,299 1,310 1,312 1,211 1,213 1,207 1,208 Other — — — 1 1 Total 1,646 1,665 1,657 1,674 2,516 2,565 2,511 2,558 (*) Under Other liabilities. From 01/01 to 12/31/2020 operations of transfer of financial assets with no retention of risks and benefits generated impact on the result of R$ 309, net of the Allowance for Loan Losses (R$ 403 from 01/01 to 12/31/2019). Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 72

Note 11—Investments in associates and joint ventures a) The following table presents non-material individual investments of ITAÚ UNIBANCO HOLDING: 12/31/2020 01/01 to 12/31/2020 Other Equity in Investment comprehensive Total Income earnings income Associates (a) 15,344 1,556 (59) 1,497 Joint ventures (b) 226 (157)—(157) Total 15,570 1,399 (59) 1,340 01/01 to 12/31/2019 01/01 to 12/31/2019 12/31/2018 Equity in Other comprehensive Equity in Investment Total Income earnings income earnings Associates (a) 14,870 1,380 1 1,381 798 Joint ventures (b) 227 (65)—(65) (51) Total 15,097 1,315 1 1,316 747 (a) At 12/31/2020, this includes interest in total capital and voting capital of the following companies: XP Inc. (41% total capital and 29.32% voting capital; 46.05% total capital and 32.49% voting capital at 12/31/2019); Pravaler S.A. (52.65% total capital and 42.42% voting capital, 52.67% total capital and 42.49% voting capital at 12/31/2019); Porto Seguro Itaú Unibanco Participações S.A. (42.93% total and voting capital; 42.93% at 12/31/2019); BSF Holding S.A. (49% total and voting capital; 49% at 12/31/2019); Gestora de Inteligência de Crédito S.A. (20% total and voting capital; 20% at 12/31/2019), Compañia Uruguaya de Medios de Procesamiento S.A. (31.47% total and voting capital; 31.93% at 12/31/2019); Rias Redbanc S.A. (25% total and voting capital; 25% at 12/31/2019); Kinea Private Equity Investimentos S.A. (80% total capital and 49% voting capital; 80% total capital and 49% voting capital at 12/31/2019) and Tecnologia Bancária S.A. (28.05% total capital and 28.95% voting capital; and 28.95% at 12/31/2019). As from April 20, 2020, ITAÚ UNIBANCO HOLDING does not exercise significant influence on IRB-Brasil Resseguros S.A., so that its ownership interest is no longer classified as associate and started being classified as Financial Asset at Fair Value through Other Comprehensive Income. (b) At 12/31/2020, this includes interest in total and voting capital of the following companies: Olímpia Promoção e Serviços S.A. (50% total and voting capital; 50% at 12/31/2019); ConectCar Soluções de Mobilidade Eletrônica S.A. (50% total and voting capital; 50% at 12/31/2019) and includes result not arising from subsidiaries’ net income. Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 73

Note 12 – Lease—Lessee ITAÚ UNIBANCO HOLDING is the lessee mainly of properties for use in its operations, which include renewal options and restatement clauses. During the period ended December 31, 2020, total cash outflow with lease amounted to R$ 673. Lease agreements in the amount of R$ 455 were renewed. There are no relevant sublease agreements. Total liabilities in accordance with remaining contractual maturities, considering their undiscounted flows, is presented below: 12/31/2020 12/31/2019 Up to 3 months 333 320 3 months to 1 year 945 886 From 1 to 5 years 2,830 2,457 Over 5 years 1,930 1,135 Total Financial Liability 6,038 4,798 Lease amounts recognized in the Consolidated Statement of Income: 01/01 to 01/01 to 12/31/2020 12/31/2019 Sublease revenues 8 12 Depreciation expenses (1,209) (1,060) Interest expenses (227) (271) Lease expenses for low value assets (87) (82) Variable expenses not include in lease liabilities (66) (81) Total (1,581) (1,482) In the period from 01/01 to 12/31/2020, there was no impairment adjustment (R$ (175) from 01/01 to 12/31/2019), recorded under the heading General and Administrative Expenses. Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 74

Note 13—Fixed assets Real estate Other fixed assets Fixed assets Other Fixed Assets (1) under Furniture and Data processing (communication, Total Land Buildings Improvements Installations construction equipment systems security and transportation) Annual depreciation rates 4% 10% 10% to 20% 10% to 20% 20% to 50% 10% to 20% Cost Balance at 12/31/2019 734 1,099 3,065 2,560 1,729 1,260 9,564 1,335 21,346 Acquisitions 457 1 37 39 59 77 976 70 1,716 Disposals (38) (27) (79) (327) (30) (104) (471) (25) (1,101) Exchange variation—4 20 191 29 83 152 12 491 Transfers (596)—196 303 79 4 10—(4) Other (2) 6 25 (85) 84 (3) 65 (1,984) 15 (1,877) Balance at 12/31/2020 563 1,102 3,154 2,850 1,863 1,385 8,247 1,407 20,571 Depreciation Balance at 12/31/2019 — (1,823) (1,755) (1,147) (909) (7,536) (983) (14,153) Depreciation expenses — (81) (285) (147) (82) (777) (122) (1,494) Disposals — 50 320 25 94 418 22 929 Exchange variation — (4) (103) (19) (52) (117) (12) (307) Other (2) — 8 (62) 30 (64) 1,639 (13) 1,538 Balance at 12/31/2020 — (1,850) (1,885) (1,258) (1,013) (6,373) (1,108) (13,487) Impairment Balance at 12/31/2019 — — — (27) - (27) Increase — (3) (112) (2) (3) — (120) Reversals — — — — -Balance at 12/31/2020 -—(3) (112) (2) (3) (27)—(147) Book value Balance at 12/31/2020 563 1,102 1,301 853 603 369 1,847 299 6,937 (1) The contractual commitments for purchase of the fixed assets totaled R$ 36, achievable by 2024 (Note 32b 3.2—Off balance commitments). (2) Includes the total amount of R$ 54 related to the hyperinflationary adjustment for Argentina. Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 75

Real estate Other fixed assets Fixed assets Other Fixed Assets under Furniture and Data processing (communication, Total Land Buildings Improvements Installations (1) construction equipment systems security and transportation) Annual depreciation rates 4% 10% 10% to 20% 10% to 20% 20% to 50% 10% to 20% Cost Balance at 12/31/2018 556 1,084 3,111 2,487 1,988 1,209 9,328 1,253 21,016 Acquisitions 473 14 38 60 10 68 868 90 1,621 Disposals—(8) (30) (97) (10) (7) (534) (5) (691) Exchange variation (1)—(6) (16) (6) (12) (34) (1) (76) Transfers (278)—107 130 27—14 —Other (2) (16) 9 (155) (4) (280) 2 (78) (2) (524) Balance at 12/31/2019 734 1,099 3,065 2,560 1,729 1,260 9,564 1,335 21,346 Depreciation Balance at 12/31/2018 — (1,929) (1,670) (1,290) (834) (7,128) (863) (13,714) Depreciation expenses — (79) (191) (136) (87) (1,043) (126) (1,662) Disposals — 21 94 8 6 483 4 616 Exchange variation — 5 8 4 6 21 1 45 Other (2) — 159 4 267—131 1 562 Balance at 12/31/2019 — (1,823) (1,755) (1,147) (909) (7,536) (983) (14,153) Impairment Balance at 12/31/2018 - — — - — -Increase — — — (27)—(27) Reversals — — — ——Balance at 12/31/2019 — — — (27)—(27) Book value Balance at 12/31/2019 734 1,099 1,242 805 582 351 2,001 352 7,166 (1) Includes financial lease contracts, mainly related to data processing equipment, which are accounted for as financial lease operations. Assets and the liabilities are recognized in the Financial Statements. (2) Includes the total amount of R$ 67 related to the hyperinflationary adjustment for Argentina. Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 76

Note 14—Goodwill and Intangible assets Intangible assets Goodwill and Association for the intangible from promotion and offer Software Acquired Internally developed Other intangible Total acquisition of financial products software assets (1) and services Annual amortization rates 8% 20% 20% 10% to 20% Cost Balance at 12/31/2019 11,158 2,518 5,899 5,716 2,971 28,262 Acquisitions 287—795 1,968 541 3,591 Rescissions / disposals — (1,121) (20) (137) (1,278) Exchange variation 2,514 320 901—232 3,967 Other (3)—(16) 10—(333) (339) Balance at 12/31/2020 13,959 2,822 6,484 7,664 3,274 34,203 Amortization Balance at 12/31/2019—(1,057) (3,206) (2,497) (1,242) (8,002) Amortization expense (2)—(174) (825) (779) (457) (2,235) Rescissions / disposals — 834—136 970 Exchange variation—(126) (451)—(174) (751) Other (3)—10 (32) (12) 327 293 Balance at 12/31/2020—(1,347) (3,680) (3,288) (1,410) (9,725) Impairment (Note 2.4h) Balance at 12/31/2019 — (171) (370)—(541) Increase (5,772) (789) (33) (13)—(6,607) Disposals — — — Balance at 12/31/2020 (5,772) (789) (204) (383)—(7,148) Book value Balance at 12/31/2020 8,187 686 2,600 3,993 1,864 17,330 (1) Includes amounts paid for acquisition of rights to provide services of payment of salaries, proceeds, retirement and pension benefits and similar benefits. (2) Amortization expenses related to the rights for acquisition of payrolls and associations, in the amount of R$ (594) (R$ (519) from 01/01 to 12/31/2019) are disclosed in the General and administrative expenses (Note 23). (3) Includes the total amount of R$ 17 related to the hyperinflationary adjustment for Argentina. Goodwill and Intangible Assets from Acquisition are mainly represented by Itaú Corpbanca’s goodwill in the amount of R$ 3,606. ITAÚ UNIBANCO HOLDING recognized adjustments to the recoverable amount of goodwill and intangible assets related to Itaú Corpbanca, in the amounts of R$ 5,772 and R$ 789. The value in use of the Cash Generating Unit (CGU) in which Itáu Corpbanca is allocated was considered and cash flows were based on the result of June 2020 and internal projects of results until 2025. The adjustment to recoverable amount results from economic conditions at June 30, 2020, of Itaú Corpbanca’s market capitalization, discount rates applicable and other changes in variables triggered by the current uncertain macroeconomic condition that, when combined, resulted in a CGU amount lower than its book value. The discount rates used for the impairment test were 10.4% for operations in Chile and 12.3% for operations in Colombia, determined by the cost of capital calculated based on CAPM model. Long-term interest rates considered were 5.2% p.a. and 6.5% p.a. for Chile and Colombia, respectively. The most sensitive assumptions are cost of capital and perpetuity growth rate. Impairment was recognized in the Consolidated Statement of Income under General and administrative expenses (Note 23). Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 77

Intangible assets (1) Goodwill and Association for the intangible from promotion and offer Internally developed Other intangible Total acquisition Software Acquired (2) of financial products software assets and services Annual amortization rates 8% 20% 20% 10% to 20% Cost Balance at 12/31/2018 11,464 2,529 5,247 4,529 2,360 26,129 Acquisitions — 789 1,187 715 2,691 Rescissions / disposals (26) (4) (93)—(130) (253) Exchange variation (285) 22 (84)—6 (341) Other (4) 5 (29) 40—20 36 Balance at 12/31/2019 11,158 2,518 5,899 5,716 2,971 28,262 Amortization Balance at 12/31/2018 (26) (867) (2,501) (1,823) (1,015) (6,232) Amortization expense (3)—(218) (675) (674) (332) (1,899) Rescissions / disposals 26 4 28—130 188 Exchange variation—(5) 45—(13) 27 Other (4)—29 (103)—(12) (86) Balance at 12/31/2019—(1,057) (3,206) (2,497) (1,242) (8,002) Impairment (Note 2.4h) Balance at 12/31/2018 — (225) (343)—(568) Incresase — (4) (27)—(31) Disposals — 58 — 58 Balance at 12/31/2019 — (171) (370)—(541) Book value Balance at 12/31/2019 11,158 1,461 2,522 2,849 1,729 19,719 (1) The contractual commitments for the purchase of the new intangible assets totaled R$ 273, achievable by 2020. (2) Includes amounts paid for acquisition of rights to provide services of payment of salaries, proceeds, retirement and pension benefits and similar benefits. (3) Amortization expenses related to the rights for acquisition of payrolls and associations, in the amount of R$ (519) (R$ (452) from 01/01 to 12/31/2018) are disclosed in the General and administrative expenses (Note 23). (4) Includes the total amount of R$ 3 related to the hyperinflationary adjustment for Argentina. Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 78

Note 15—Deposits 12/31/2020 12/31/2019 Current Non-current Total Current Non-current Total Interest-bearing deposits 376,139 297,995 674,134 251,882 172,863 424,745 Savings deposits 179,470—179,470 144,558—144,558 Interbank deposits 3,185 245 3,430 2,866 155 3,021 Time deposits 193,484 297,750 491,234 104,458 172,708 277,166 Non-interest bearing deposits 134,876—134,876 82,315—82,315 Demand deposits 134,805—134,805 82,306—82,306 Others deposits 71—71 9—9 Total 511,015 297,995 809,010 334,197 172,863 507,060 Note 16 – Financial liabilities designated at fair value through profit or loss 12/31/2020 12/31/2019 Current Non-current Total Current Non-current Total Structured notes Shares ——11—11 Debt securities 11 132 143 38 152 190 Total 11 132 143 49 152 201 The effect of credit risk of these instruments is not significant at 12/31/2020 and 12/31/2019. Shares and debt securities do not have a defined amount on maturity, since they vary according to stock market quotation and an exchange variation component, respectively. Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 79

Note 17 – Securities sold under repurchase agreements and interbank and institutional market funds a) Securities sold under repurchase agreements The table below shows the breakdown of funds: 12/31/2020 12/31/2019 Interest rate (p.a.) Non- Non- Current Total Current Total current current Assets pledged as collateral 45,961 564 46,525 67,065 2,696 69,761 Government securities 1.70% to 1.90% 22,088—22,088 46,271—46,271 Corporate securities 45% of CDI to 98.5% of CDI 20,773—20,773 17,665—17,665 Own issue 100% of Selic to 16.40% 1,965 20 1,985 2,831 2,427 5,258 Foreign 0.03% to 2.20% 1,135 544 1,679 298 269 567 Assets received as collateral 1.38% to 1.90% 151,370—151,370 140,004 - 140,004 Right to sell or repledge the collateral 0.01% to 10.0% 27,851 47,618 75,469 16,807 30,011 46,818 Total 225,182 48,182 273,364 223,876 32,707 256,583 b) Interbank market funds 12/31/2020 12/31/2019 Interest rate (p.a.) Non- Non- Current Total Current Total current current Financial bills 2.76% to 29.34% 21,898 21,691 43,589 20,829 44,604 65,433 Real state credit bills 1.65% to 11.83% 2,600 1,605 4,205 6,194 1,441 7,635 Agribusiness credit bills 1.39% to 14.30% 10,166 4,119 14,285 14,543 6,661 21,204 Guaranteed real state notes 2.62% to 9.43% 437 10,592 11,029—4,320 4,320 Import and export financing 0% to 9.60% 56,148 15,322 71,470 59,810 4,812 64,622 On-lending-domestic 0% to 18% 3,672 7,785 11,457 3,863 7,785 11,648 Total 94,921 61,114 156,035 105,239 69,623 174,862 Funding for import and export financing represents credit facilities available for financing of imports and exports of Brazilian companies, in general denominated in foreign currency. c) Institutional market funds 12/31/2020 12/31/2019 Interest rate (p.a.) Non- Non- Current Total Current Total current current Subordinated debt (1) 12,125 62,791 74,916 LIBOR to IGPM + 4.63% 4,098 55,364 59,462 Obligations on securities abroad -0.05% to 29.75% 6,636 55,797 62,433 9,162 34,510 43,672 Raisings through Structured Operations Certificates (2) 1.41% to 11.12% 578 381 959 575 535 1,110 Total 19,339 118,969 138,308 13,835 90,409 104,244 (1) At 12/31/2020, the amount of R$ 41,000 (R$ 36,627 at 12/31/2019) is included in the Reference Equity, under the proportion defined by CMN Resolution No. 4,192, on March 01, 2013. (2) At 12/31/2020, the fair value of raisings through Structured Operations Certificates issued is R$ 1,018 (R$ 1,204 at 12/31/2019). Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 80

Note 18—Other assets and liabilities a) Other assets 12/31/2020 12/31/2019 Non- Non- Current Total Current Total current current Financial 81,144 12,117 93,261 87,498 7,254 94,752 At Amortized Cost 81,138 12,117 93,255 87,498 7,254 94,752 Receivables from credit card issuers 43,511—43,511 42,395—42,395 Deposits in guarantee for contingent liabilities, provisions and legal obligations (Note 29e) 1,338 11,355 12,693 7,990 6,530 14,520 Trading and intermediation of securities 28,021 233 28,254 26,544 207 26,751 Income receivable 2,941 38 2,979 3,236—3,236 Operations without credit granting characteristics, net of provisions 2,995 481 3,476 3,612 5 3,617 Insurance and reinsurance operations 1,312 10 1,322 836 511 1,347 Net amount receivables from reimbursement of provisions (Note 29d) 919—919 978—978 Deposits in guarantee of fund raisings abroad 101—101 1,864 1 1,865 Other ——43—43 At Fair Value Through Profit or Loss 6—6 ——Other financial assets 6—6 ——Non-financial 9,175 6,598 15,773 9,323 5,368 14,691 Sundry foreign 713 4 717 639 7 646 Prepaid expenses 3,230 1,174 4,404 3,288 1,038 4,326 Sundry domestic 2,552 3 2,555 2,916 9 2,925 Assets of post-employment benefit plans (Note 26e)—585 585—717 717 Lease right-of-use 76 4,832 4,908 211 3,597 3,808 Other 2,604—2,604 2,269—2,269 b) Other liabilities 12/31/2020 12/31/2019 Non- Non- Current Total Current Total current current Financial 112,745 6,184 118,929 113,092 3,989 117,081 At Amortized Cost 112,740 6,184 118,924 113,092 3,989 117,081 Credit card operations 92,580—92,580 87,361—87,361 Trading and intermediation of securities 14,995 126 15,121 18,062 65 18,127 Foreign exchange portfolio 859—859 1,245—1,245 Finance leases 49 5,020 5,069 207 3,924 4,131 Other 4,257 1,038 5,295 6,217—6,217 At Fair Value Through Profit or Loss 5—5 ——Other financial liabilities 5—5 ——Non-financial 35,248 3,263 38,511 26,275 2,063 28,338 Funds in transit 15,944 127 16,071 10,573 11 10,584 Charging and collection of taxes and similar 339—339 335—335 Social and statutory 6,201 558 6,759 5,057 32 5,089 Deferred income 3,201—3,201 2,686—2,686 Sundry domestic 2,957 66 3,023 2,118 79 2,197 Personnel provision 1,609 291 1,900 1,569 75 1,644 Provision for sundry payments 2,506 70 2,576 1,761 63 1,824 Obligations on official agreements and rendering of payment services 1,326—1,326 1,114—1,114 Liabilities from post-employment benefit plans (Note 26e)—2,083 2,083—1,746 1,746 Other 1,165 68 1,233 1,062 57 1,119 Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 81

Note 19 – Stockholders’ equity a) Capital Capital is represented by 9,804,135,348 book-entry shares with no par value, of which 4,958,290,359 are common shares and 4,845,844,989 are preferred shares with no voting rights, but with tag-along rights in a public offering of shares, in an eventual transfer of control, assuring them a price equal to eighty per cent (80%) of the amount paid per voting share in the controlling block, and a dividend at least equal to that of the common shares. The breakdown and change in shares of paid-in capital in the beginning and end of the period are shown below: 12/31/2020 Number Amount Common Preferred Total Residents in Brazil at 12/31/2019 4,931,023,4161,665,657,332 6,596,680,748 65,366 Residents abroad at 12/31/2019 27,266,9433,180,187,657 3,207,454,600 31,782 Shares of capital stock at 12/31/2019 4,958,290,3594,845,844,989 9,804,135,348 97,148 Shares of capital stock at 12/31/2020 4,958,290,3594,845,844,989 9,804,135,348 97,148 Residents in Brazil at 12/31/2020 4,929,824,2811,820,159,657 6,749,983,938 66,885 Residents abroad at 12/31/2020 28,466,0783,025,685,332 3,054,151,410 30,263 Treasury shares at 12/31/2019 (1)—58,533,585 58,533,585 (1,274) Result from delivery of treasury shares—(16,855,133) (16,855,133) 367 Treasury shares at 12/31/2020 (1)—41,678,452 41,678,452 (907) Outstanding shares at 12/31/2020 4,958,290,359 4,804,166,537 9,762,456,896 Outstanding shares at 12/31/2019 4,958,290,3594,787,311,404 9,745,601,763 12/31/2019 Number Amount Common Preferred Total Residents in Brazil at 12/31/2018 4,928,076,320 1,609,055,166 6,537,131,486 64,776 Residents abroad at 12/31/2018 30,214,0393,236,789,823 3,267,003,862 32,372 Shares of capital stock at 12/31/2018 4,958,290,359 4,845,844,989 9,804,135,348 97,148 Shares of capital stock at 12/31/2019 4,958,290,359 4,845,844,989 9,804,135,348 97,148 Residents in Brazil at 12/31/2019 4,931,023,416 1,665,657,332 6,596,680,748 65,366 Residents abroad at 12/31/2019 27,266,943 3,180,187,657 3,207,454,600 31,782 Treasury shares at 12/31/2018 (1)—83,614,426 83,614,426 (1,820) Result from delivery of treasury shares—(25,080,841) (25,080,841) 546 Treasury shares at 12/31/2019 (1)—58,533,585 58,533,585 (1,274) Outstanding shares at 12/31/2019 4,958,290,359 4,787,311,404 9,745,601,763 Outstanding shares at 12/31/2018 4,958,290,359 4,762,230,563 9,720,520,922 (1) Own shares, purchased based on authorization of the Board of Directors, to be held in Treasury for subsequent cancellation of replacement in the market. Below is the average cost of treasury shares and their market price in reais. In 2020, there was none acquisition of treasury shares. 12/31/2020 Cost / market value Common Preferred Average cost—21.76 Market value at 12/31/2020 27.93 31.63 12/31/2019 Cost / market value Common Preferred Average cost—21.76 Market value at 12/31/2019 32.03 37.10 Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 82

b) Dividends Shareholders are entitled to a mandatory minimum dividend in each fiscal year, corresponding to 25% of adjusted net income, as set forth in the Bylaws. Common and preferred shares participate equally in income distributed, after common shares have received dividends equal to the minimum annual priority dividend payable to preferred shares (R$ 0.022 non-cumulative per share). ITAÚ UNIBANCO HOLDING monthly advances the mandatory minimum dividend, using the share position of the last day of the previous month as the calculation basis, and the payment made on the first business day of the subsequent month in the amount of R$ 0.015 per share. l—Calculation of dividends and interest on capital 12/31/2020 12/31/2019 12/31/2018 Statutory net income 18,961 26,712 21,945 Adjustments: (-) Legal reserve—5% (948) (1,336) (1,097) Dividend calculation basis 18,013 25,376 20,848 Minimun mandatory dividend—25% 4,503 6,344 5,212 Dividends and Interest on Capital Paid / Accrued 4,503 18,777 22,437 ll—Stockholders’ compensation 12/31/2020 Gross value WHT (With Value Net per share (R$) holding tax) Paid / Prepaid 2,127 (78) 2,049 Dividends—11 monthly installments paid from February to December 2020 0.0150 1,610—1,610 Interest on capital—paid on 08/26/2020 0.0450 517 (78) 439 Accrued (Recorded in Other Liabilities) 2,861 (407) 2,454 Dividends—1 monthly installment paid on 01/04/2021 0.0150 146—146 Interest on capital—credited on December 17, 2020 to be paid until April 30, 2021 0.0544 624 (93) 531 Interest on capital—credited on January 28, 2021 to be paid until April 30, 2021 0.0426 490 (74) 416 Dividends or Interest on capital 0.1394 1,601 (240) 1,361 Total from 01/01 to 12/31/2020 4,988 (485) 4,503 12/31/2019 Gross value WHT (With Value Net per share (R$) holding tax) Paid / Prepaid 9,274—9,274 Dividends—11 monthly installments paid from February to December 2019 0.0150 1,606—1,606 Dividends—paid on 08/23/2019 0.7869 7,668—7,668 Accrued (Recorded in Other Liabilities) 512 (55) 457 Dividends—1 monthly installment paid on 01/02/2020 0.0150 146—146 Interest on capital—credited on December 19, 2019 to be paid until April 30, 2020 0.0376 366 (55) 311 Identified in Profit Reserves In Stockholders’ Equity 1.0067 9,811 (765) 9,046 Total from 01/01 to 12/31/2019 19,597 (820) 18,777 12/31/2018 Gross value WHT (With Gross Net per share (R$) holding tax) Paid / prepaid 5,921 (122) 5,799 Dividends—11 monthly installments from February to December 2018 0.0150 1,069—1,069 Dividends—paid on 08/30/2018 0.6240 4,041—4,041 Interest on capital—paid on 08/30/2018 0.1252 811 (122) 689 Accrued (Recorded in Other Liabilities) 248 (15) 233 Dividends—1 monthly installment paid on 01/02/2019 0.0150 145—145 Interest on capital—credited on December 27, 2018 to be paid until April 30, 2019 0.0106 103 (15) 88 Identified in Profit Reserves In Stockholders’ Equity 1.8001 17,498 (1,093) 16,405 Total from 01/01 to 12/31/2018 23,667 (1,230) 22,437 Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 83

c) Capital reserves and profit reserves l—Additional paid-in capital Additional paid-in capital corresponds to: (i) the difference between the sale price of treasury shares and the average cost of such shares, and (ii) the yield expenses recognized in accordance with the stock option plan and variable compensation. ll—Appropriated reserves 12/31/2020 12/31/2019 12/31/2018 Capital reserves 285 285 285 Premium on subscription of shares 284 284 284 Reserves from tax incentives, restatement of equity securities and other 1 1 1 Profit reserves 16,943 12,663 13,195 Legal (1) 12,274 11,326 9,989 Statutory (2) 16,186 3,043 (2,775) Corporate reorganizations (Note 2.4 a IV) (11,517) (11,517) (11,517) Special profit reserves (3)—9,811 17,498 Total reserves at parent company 17,228 12,948 13,480 (1) Its purpose is to ensure the integrity of capital, compensate loss or increase capital. (2) Its main purpose is to ensure the yield flow to shareholders. (3) Refers to Dividends or Interest on Capital declared after 12/31/2020, 12/31/2019 and 12/31/2018. lll—Unappropriated reserves Refers to balance of net income remaining after the distribution of dividends and appropriations to statutory reserves in the statutory accounts of ITAÚ UNIBANCO HOLDING. d) Non-controlling interests Stockholders’ equity Income 01/01 to 01/01 to 12/31/2020 12/31/2019 12/31/2020 12/31/2019 Itaú CorpBanca 9,891 11,270 (4,135) 504 Itaú CorpBanca Colômbia S.A. 491 406 (15) (16) Financeira Itaú CBD S.A. Crédito, Financiamento e Investimento 580 446 164 131 Luizacred S.A. Soc. Cred. Financiamento Investimento 385 295 102 20 Other 185 123 52 61 Total 11,532 12,540 (3,832) 700 Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 84

Note 20 – Share-based payment ITAÚ UNIBANCO HOLDING and its subsidiaries have share-based payment plans aimed at involving its management members and employees in the medium and long term corporate development process. The grant of these benefits is only made in years in which there are sufficient profits to permit the distribution of mandatory dividends, limiting dilution to 0.5% of the total shares held by the controlling and minority stockholders at the balance sheet date. These programs are settled through the delivery of ITUB4 treasury shares to stockholders. Expenses on share-based payment plans are presented in the table below: 01/01 to 01/01 to 01/01 to 12/31/2020 12/31/2019 12/31/2018 Partner Plan (241) (242) (226) Share-based plan (489) (384) (377) Total (730) (626) (603) l – Partner Plan The program enables employees and managers of ITAÚ UNIBANCO HOLDING to invest a percentage of their bonus to acquire shares and share-based instruments. There is a lockup period of from three to five years, counted from the initial investment date, and the shares are thus subject to market price variations. After complying with the preconditions outlined in the program, beneficiaries are entitled to receive shares as consideration, in accordance with the number of shares indicated in the regulations. The acquisition price of shares and share-based instruments is established every six months as the average of the share price over the last 30 days, which is performed on the seventh business day prior to the remuneration grant date. The fair value of the consideration in shares is the market price at the grant date, less expected dividends. Change in the Partner Program 01/01 to 01/01 to 12/31/2020 12/31/2019 Quantity Quantity Opening balance 39,305,211 48,871,182 New 10,488,126 8,096,700 Delivered (11,408,109) (15,627,167) Cancelled (2,093,468) (2,035,504) Closing balance 36,291,760 39,305,211 Weighted average of remaining contractual life (years) 1.69 1.59 Market value weighted average (R$) 23.37 25.49 Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 85

II—Variable compensation In this plan, 50% of variable compensation of managers is paid in cash and 50% is paid in shares for a period of three years. Shares are delivered on a deferred basis, of which one-third per year, will be contingent upon the executive’s permancence in the institution. The deferred unpaid portions may be reversed proportionally to a significant reduction in the recurring income realized or the negative income for the period. Management members become eligible for the receipt of these benefits according to individual performance, business performance or both. The benefit amount is established according to the activities of each management member who should meet at least the performance and conduct requirements. The fair value of the share is the market price at its grant date. Change in share-based variable compensation 01/01 to 01/01 to 12/31/2020 12/31/2019 Quantity Quantity Opening balance 20,220,934 25,016,145 New 18,329,108 9,794,250 Delivered (10,574,321) (14,237,280) Cancelled (568,490) (352,181) Closing balance 27,407,231 20,220,934 Market value weighted average (R$) 31.22 37.55 Ill – Stock Option Plan (Simple Options) ITAÚ UNIBANCO HOLDING had a Stock Option Plan (“Simple Options”), which was discontinued, and the last options were vested in 2019. Simple options have the following characteristics: a) Exercise price: calculated as the average prices of shares in the three months of the year prior to the grant date. The prices determined are inflation-adjusted to the last business day of the month prior to the option exercise date in line with the IGP-M inflation index or, in its absence, an index to be determined internally, and must be paid according to the regulations for the settlement of trading on B3. b) Vesting period: determined upon issue, from one to seven years, counted from the grant date. The vesting period is normally five years. Change in the Simple options plan 01/01 to 12/31/2020 01/01 to 12/31/2019 Weighted average Weighted average Quantity Quantity exercise price exercise price Opening balance — 3,089,599 22.11 Options vested at the end of the period — 3,089,599 22.11 Options: Canceled / Forfeited (*) — (72,318) 24.36 Exercised — (3,017,281) 22.68 Closing balance — — Options vested at the end of the period — —Range of exercise prices—22.95 Weighted average of the remaining contractual life (in years) — Market value weighted average (R$)—36.34 (*) Refers to non-vesting based on the beneficiary’s decision. Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 86

Note 21—Interest and similar income and expense and net gain (loss) a) Interest and similar income of financial assets at amortized cost and at fair value through other comprehensive income 01/01 to 01/01 to 01/01 to 12/31/2020 12/31/2019 12/31/2018 Compulsory deposits in the Central Bank of Brazil 2,242 4,734 5,063 Interbank deposits 1,102 1,173 1,080 Securities purchased under agreements to resell 9,832 16,197 17,365 Financial assets at fair value through other comprehensive income 16,982 10,758 9,194 Financial assets at amortized cost 3,629 2,582 2,614 Loan operations 79,503 81,046 73,640 Other financial assets (28) 1,033 1,368 Total 113,262 117,523 110,324 b) Interest and similar expense 01/01 to 01/01 to 01/01 to 12/31/2020 12/31/2019 12/31/2018 Deposits (17,478) (18,559) (17,484) Securities sold under repurchase agreements (10,690) (20,473) (20,889) Interbank market funds (28,878) (13,231) (13,587) Institutional market funds (8,400) (6,837) (6,773) Financial expense from technical provisions for insurance and private pension (8,121) (16,720) (11,815) Other 9 (138) (64) Total (73,558) (75,958) (70,612) c) Adjustment to Fair Value of Financial Assets and Liabilities 01/01 to 01/01 to 01/01 to 12/31/2020 12/31/2019 12/31/2018 Financial assets at fair value through profit or loss 319 3,628 (4,110) Derivatives (*) (9,393) (70) (260) Financial assets designated at fair value through profit or loss (118) (64) (218) Financial assets at fair value through other comprehensive income 1,107 628 (254) Financial liabilities at fair value through profit or loss (9) —Financial liabilities designated at fair value 38 (24) 8 Total (8,056) 4,098 (4,834) (*) Includes the ineffective derivatives portion related to hedge accounting. During the period ended 12/31/2020, ITAÚ UNIBANCO HOLDING recognized R$ (419) of Expected Losses (R$ 1 at 12/31/2019) with loss of R$ (7) for Financial Assets – Fair Value through Other Comprehensive Income and loss of R$ (412) for Financial Assets – Amortized Cost (R$ 993 at 12/31/2019). Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 87

Note 22—Commissions and Banking Fees 01/01 to 01/01 to 01/01 to 12/31/2020 12/31/2019 12/31/2018 Credit and debit cards 13,813 15,619 15,634 Current account services 8,002 7,969 7,802 Asset management 6,951 6,322 5,017 Funds 6,316 5,702 4,470 Consortia 635 620 547 Credit operations and financial guarantees provided 2,298 2,418 2,419 Credit operations 964 1,048 948 Financial guarantees provided 1,334 1,370 1,471 Collection services 1,897 1,831 1,770 Advisory services and brokerage 2,891 2,509 1,632 Custody services 573 501 435 Other 2,132 1,863 2,100 Total 38,557 39,032 36,809 Note 23—General and administrative expenses 01/01 to 01/01 to 01/01 to 12/31/2020 12/31/2019 12/31/2018 Personnel expenses (25,158) (28,415) (24,846) Compensation (10,212) (9,548) (10,226) Employees’ profit sharing (4,224) (5,183) (4,425) Welfare benefits (4,059) (3,856) (3,764) Provision for labor claims and dismissals (2,922) (5,640) (2,907) Payroll charges (3,330) (3,276) (3,011) Share-based payment (Note 20) (241) (242) (226) Training (107) (178) (253) Other (63) (492) (34) Administrative expenses (16,904) (15,912) (17,268) Third party services (5,148) (4,571) (4,482) Data processing and telecommunications (3,983) (4,278) (4,273) Installations (2,005) (2,068) (3,306) Advertising, promotions and publicity (1,095) (1,325) (1,419) Financial services expenses (915) (798) (790) Security (730) (744) (754) Transportation (347) (364) (350) Materials (321) (330) (339) Travel expenses (84) (240) (232) Other (1) (2,276) (1,194) (1,323) Depreciation and Amortization (5,064) (4,630) (3,332) Other expenses (17,081) (12,055) (12,092) Selling—credit cards (4,391) (4,958) (4,285) Claims losses (778) (825) (675) Loss on sale of other assets, fixed assets and investments in associates (683) (719) (632) and joint ventures Provision for lawsuits civil (Note 29) (1,080) (848) (464) Provision for tax and social security lawsuits (191) (1,898) (328) Refund of interbank costs (270) (307) (272) Impairment (2) (6,201) (233) (168) Other (3,487) (2,267) (5,268) Total (64,207) (61,012) (57,538) (1) At 12/31/2020 comprises R$ (1,047) related to donations for the initiative “Todos pela Saúde” (All for Health) (Note 33a). (2) The effects of impairment of goodwill and intangible assets of Itaú Corpbanca, net of tax effects and ownership interest of non-controlling shareholders total R$ (1,452). Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 88

Note 24 – Taxes ITAÚ UNIBANCO HOLDING and each one of its subsidiaries calculate separately, in each fiscal year, Income Tax and Social Contribution on Net Income. Taxes are calculated at the rates shown below and consider, for effects of respective calculation bases, the legislation in force applicable to each charge. Income tax 15.00% Additional income tax 10.00% Social contribution on net income (*) 20.00% (*) Constitutional Amendment (EC) No. 103/2019: disseminated on November 12, 2019, it provides for the Social Security and other matters, also addressing the increase of the tax rate of Social Contribution on Net Income for banks set forth in item I of paragraph 1 of article 1 of Supplementary Law No. 105, of January 10, 2001, that was changed to 20% as from March 1, 2020. For the other financial subsidiaries and equivalent companies, the tax rate remains at 15%, and for the non-financial ones at 9%. a) Expenses for taxes and contributions Breakdown of income tax and social contribution calculation: 01/01 to 01/01 to 01/01 to Due on operations for the period 12/31/2020 12/31/2019 12/31/2018 Income / (loss) before income tax and social contribution 5,230 31,243 30,608 Charges (income tax and social contribution) at the rates in effect (2,354) (12,497) (13,774) Increase / decrease in income tax and social contribution charges arising from: Share of profit or (loss) of associates and joint ventures 384 614 403 Foreign exchange variation on investments abroad 7,201 711 4,381 Interest on capital 2,765 3,012 3,791 Corporate reorganizations (Note 2.4 a IV) — 628 Other nondeductible expenses net of non taxable income (*) (16,651) (932) 2,007 Income tax and social contribution expenses (8,655) (9,092) (2,564) Related to temporary differences Increase / (reversal) for the period 18,489 5,750 (2,650) Increase / (reversal) of prior periods—(88) 245 (Expenses) / Income from deferred taxes 18,489 5,662 (2,405) Total income tax and social contribution expenses 9,834 (3,430) (4,969) (*) Includes temporary (additions) and exclusions. Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 89

b) Deferred taxes I—The deferred tax asset balance and its changes, segregated based on its origin and disbursements, are represented by: Realization / 12/31/2019 Increase 12/31/2020 Reversal Reflected in income 43,380 (12,631) 29,499 60,248 Provision for expected loss 22,860 (3,885) 8,958 27,933 Related to tax losses and social contribution loss carryforwards 2,585 (540) 3,483 5,528 Provision for profit sharing 2,162 (2,162) 1,903 1,903 Provision for devaluation of securities with permanent impairment 1,530 (877) 917 1,570 Provisions 6,208 (2,064) 1,701 5,845 Civil lawsuits 1,413 (547) 465 1,331 Labor claims 3,251 (1,338) 1,143 3,056 Tax and social security lawsuits 1,544 (179) 93 1,458 Legal obligations 723 (7) 58 774 Adjustments of operations carried out on the futures settlement market 84 (84) 52 52 Adjustment to Fair Value of Financial Assets—At Fair Value Through Profit 738 (738) 8,315 8,315 or Loss Provision relating to health insurance operations 348—8 356 Other 6,142 (2,274) 4,104 7,972 Reflected in stockholders’ equity 2,354 (1,191) 212 1,375 Adjustment to Fair Value of Financial Assets—At Fair Value Through Other 766 (762) 56 60 Comprehensive Income Cash flow hedge 1,187 (429)—758 Other 401—156 557 Total (1) (2) 45,734 (13,822) 29,711 61,623 (1) Deferred income tax and social contribution assets and liabilities are recorded in the balance sheet offset by a taxable entity and amounting to R$ 56,583 and R$ 421, respectively. (2) The accounting records of deferred tax assets on income tax losses and/or social contribution loss carryforwards, as well as those arising from temporary differences, are based on technical feasibility studies which consider the expected generation of future taxable income, considering the history of profitability for each subsidiary individually, and for the consolidated taken as a whole. Realization / 12/31/2018 Increase 12/31/2019 Reversal Reflected in income 37,252 (13,667) 19,795 43,380 Provision for expected loss 18,563 (4,712) 9,009 22,860 Related to tax losses and social contribution loss carryforwards 4,391 (2,339) 533 2,585 Provision for profit sharing 1,844 (1,844) 2,162 2,162 Provision for devaluation of securities with permanent impairment 1,729 (902) 703 1,530 Provisions 4,464 (1,552) 3,296 6,208 Civil lawsuits 1,586 (651) 478 1,413 Labor claims 2,037 (790) 2,004 3,251 Tax and social security lawsuits 841 (111) 814 1,544 Goodwill on purchase of investments 60 (60) —Legal obligations 676 (57) 104 723 Adjustments of operations carried out in futures settlement market 98 (98) 84 84 Adjustment to Fair Value of Financial Assets—At Fair Value Through Profit 631 (631) 738 738 or Loss Provision relating to health insurance operations 343—5 348 Other 4,453 (1,472) 3,161 6,142 Reflected in stockholders’ equity 1,888 (509) 975 2,354 Adjustment to Fair Value of Financial Assets—At Fair Value Through Other 383 (163) 546 766 Comprehensive Income Cash flow hedge 1,149 (93) 131 1,187 Other 356 (253) 298 401 Total (1) (2) 39,140 (14,176) 20,770 45,734 (1) Deferred income tax and social contribution assets and liabilities are recorded in the balance sheet offset by a taxable entity and amounting to R$ 38,914 and R$ 1,058, respectively. (2) At 12/31/2019, deferred tax asset balance comprised its annual revaluation and effects caused by EC 103/2019 in tax rate of the Social Contribution on Net Income, which was increased from 15% to 20%, reaching the institutions set forth in item I of paragraph 1 of article 1 of Supplementary Law No. 105, of January 10, 2001, totaling R$ 1,614. Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 90

II—The deferred tax liabilities and its changes are represented by: Realization / 12/31/2019 Increase 12/31/2020 reversal Reflected in income 6,610 (2,951) 1,194 4,853 Depreciation in excess finance lease 202 (57)—145 Adjustment of deposits in guarantee and provisions 1,531 (133) 6 1,404 Post-employment benefits 282 (111) 9 180 Adjustments of operations carried out on the futures settlement market 1,330 (1,330) 452 452 Adjustment to Fair Value of Financial Assets—At Fair Value Through Profit 1,149 (1,149) 136 136 or Loss Taxation of results abroad – capital gains 581—63 644 Other 1,535 (171) 528 1,892 Reflected in stockholders’ equity 1,268 (859) 199 608 Adjustment to Fair Value of Financial Assets—At Fair Value Through Other 1,228 (826) 199 601 Comprehensive Income Cash flow hedge 30 (26)—4 Post-employment benefits 10 (7)—3 Total (*) 7,878 (3,810) 1,393 5,461 (*) Deferred income tax and social contribution asset and liabilities are recorded in the balance sheet offset by a taxable entity and amounting to R$ 56,583 and R$ 421, respectively. Realization / 12/31/2018 Increase 12/31/2019 reversal Reflected in income 6,144 (3,863) 4,329 6,610 Depreciation in excess finance lease 346 (144)—202 Adjustment of deposits in guarantee and provisions 1,348 (29) 212 1,531 Post-employment benefits 287 (56) 51 282 Adjustments of operations carried out on the futures settlement market 923 (923) 1,330 1,330 Adjustment to Fair Value of Financial Assets—At Fair Value Through Profit 1,790 (1,790) 1,149 1,149 or Loss Taxation of results abroad – capital gains 659 (142) 64 581 Other 791 (779) 1,523 1,535 Reflected in stockholders’ equity 662 (262) 868 1,268 Adjustment to Fair Value of Financial Assets—At Fair Value Through Other 474 (107) 861 1,228 Comprehensive Income Cash flow hedge 168 (142) 4 30 Post-employment benefits 7—3 10 Other 13 (13) — Total (*) 6,806 (4,125) 5,197 7,878 (*) Deferred income tax and social contribution asset and liabilities are recorded in the balance sheet offset by a taxable entity and amounting to R$ 38,914 and R$ 1,058, respectively. III—The estimate of realization and present value of deferred tax assets and deferred tax liabilities are: Deferred tax assets Net Year of Tax loss / social Deferred tax Temporary % deferred % realization % contribution loss % Total % liabilities differences taxes carryforwards 2021 10,792 19% 971 18% 11,763 19% (168) 3% 11,595 21% 2022 15,832 28% 521 9% 16,353 27% (500) 9% 15,853 28% 2023 14,821 26% 566 10% 15,387 25% (186) 4% 15,201 27% 2024 3,245 6% 664 12% 3,909 6% (136) 2% 3,773 7% 2025 2,571 5% 714 13% 3,285 5% (212) 4% 3,073 5% After 2025 8,834 16% 2,092 38% 10,926 18% (4,259) 78% 6,667 12% Total 56,095 100% 5,528 100% 61,623 100% (5,461) 100% 56,162 100% Present value (*) 53,476 5,147 58,623 (4,847) 53,776 (*) The average funding rate, net of tax effects, was used to determine the present value. Projections of future taxable income include estimates of macroeconomic variables, exchange rates, interest rates, volumes of financial operations and services fees and others factors, which can vary in relation to actual data and amounts. Net income in the financial statements is not directly related to the taxable income for income tax and social contribution, due to differences between accounting criteria and the tax legislation, in addition to corporate aspects. Accordingly, it is recommended that changes in realization of deferred tax assets presented below are not considered as an indication of future net income. IV—At 12/31/2020, deferred tax assets not accounted for correspond to R$ 780 and result from Management’s evaluation of their perspectives of realization in the long term (R$ 605 at 12/31/2019) . Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 91

c) Tax liabilities 12/31/2020 12/31/2019 Taxes and contributions on income payable 970 3,083 Other Taxes and Contributions payable 1,908 914 Deferred tax liabilities (Note 24b II) 421 1,058 Other 2,411 2,836 Total 5,710 7,891 Note 25 – Earnings per share a) Basic earnings per share Net income attributable to ITAÚ UNIBANCO HOLDING’s shareholders is divided by the average number of outstanding shares in the period, excluding treasury shares. 01/01 to 01/01 to 01/01 to 12/31/2020 12/31/2019 12/31/2018 Net income attributable to owners of the parent company 18,896 27,113 24,907 Minimum non-cumulative dividends on preferred shares (106) (105) (104) Retained earnings to be distributed to common equity owners in an amount per share equal to the minimum dividend payable to preferred equity owners (109) (109) (109) Retained earnings to be distributed, on a pro rata basis, to common and preferred equity owners: Common 9,491 13,693 12,599 Preferred 9,190 13,206 12,095 Total net income available to equity owners: Common 9,600 13,802 12,708 Preferred 9,296 13,311 12,199 Weighted average number of outstanding shares Common 4,958,290,359 4,958,290,359 4,958,290,359 Preferred 4,801,324,161 4,781,855,588 4,759,872,085 Basic earnings per share – R$ Common 1.94 2.78 2.56 Preferred 1.94 2.78 2.56 b) Diluted earnings per share Calculated similarly to the basic earnings per share; however, it includes the conversion of all preferred shares potentially dilutable in the denominator. 01/01 to 01/01 to 01/01 to 12/31/2020 12/31/2019 12/31/2018 Net income available to preferred equity owners 9,296 13,311 12,199 Dividends on preferred shares after dilution effects 41 64 72 Net income available to preferred equity owners considering preferred shares after the dilution effect 9,337 13,375 12,271 Net income available to ordinary equity owners 9,600 13,802 12,708 Dividend on preferred shares after dilution effects (41) (64) (72) Net income available to ordinary equity owners considering preferred shares after the dilution effect 9,559 13,738 12,636 Adjusted weighted average of shares Common 4,958,290,359 4,958,290,359 4,958,290,359 Preferred 4,843,233,835 4,826,925,107 4,815,473,777 Preferred 4,801,324,161 4,781,855,588 4,759,872,085 Incremental as per share-based payment plans 41,909,674 45,069,519 55,601,692 Diluted earnings per share – R$ Common 1.93 2.77 2.55 Preferred 1.93 2.77 2.55 There was no potentially antidulitive effect of the shares in share-based payment plans in the periods of 2020, 2019 and 2018. Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 92

Note 26 – Post-employment benefits ITAÚ UNIBANCO HOLDING, through its subsidiaries, sponsors retirement plans for its employees. Retirement plans are managed by Closed-end Private Pension Entities (EFPC) and are closed to new applicants. These entities have an independent structure and manage their plans according to the characteristics of their regulations. There are three types of retirement plan: · Defined Benefit Plans (BD): plans which scheduled benefits have their value established in advance, based on salaries and/or length of service of employees, and its cost is actuarially determined; · Defined Contribution Plans (CD): are those plans which scheduled benefits have their value permanently adjusted to the investments balance, kept in favor of the participant, including in the benefit concession phase, considering net proceedings of its investment, amounts contributed and benefits paid; and · Variable Contribution Plans (CV): in this type of plan, scheduled benefits present a combination of characteristics of defined contribution and defined benefit modalities, and the benefit is actuarially determined based on the investments accumulated balance by the participant on the retirement date. Below is a list of benefit plans and their modalities: Entity Benefit Plan Modality Supplementary Retirement Plan Supplementary Retirement Plan – Flexible Premium Annuity Franprev Benefit Plan 002 Benefit Plan Prebeg Benefit Plan Defined Benefit UBB PREV Defined Benefit Plan Benefit Plan II Itaulam Basic Plan Fundação Itaú Unibanco – Previdência Itaucard Defined Benefit Plan Complementar—FIU Itaú Unibanco Main Retirement Plan Itaubanco Defined Contribution Plan Itaubank Retirement Plan Defined Contribution Redecard Pension Plan Unibanco Pension Plan – Intelligent Future Itaulam Supplementary Plan Variable Contribution Itaucard Variable Contribution Plan Itaú Unibanco Supplementary Retirement Plan FUNBEP – Fundo de Pensão Benefit Plan l Defined Benefit Multipatrocinado Benefit Plan ll Variable Contribution Defined Contribution plans include pension funds consisting of the portions of sponsor’s contributions not included in a participant’s account balance due to loss of eligibility for the benefit, and of monies arising from the migration of retirement plans in defined benefit modality. These funds are used for future contributions to individual participants’ accounts, according to the respective benefit plan regulations. Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 93

a) Main Actuarial Assumptions Actuarial assumptions of demographic and financial nature should reflect the best estimates about the variables that determine the post-employment benefit obligations. The main demographic assumptions comprise: mortality table and turnover of active participants, while the main financial assumptions include: discount rate, future salary increases, growth of plan benefits and inflation. 12/31/2020 12/31/2019 Discount rate (1) 7.64% p.a. 7.64% p.a. Mortality table (2) AT-2000 AT-2000 Turnover (3) Itaú Experience 2008/2010 Itaú Experience 2008/2010 Future salary growth 4.00% to 7.12% p.a. 4.00% to 7.12% p.a. Growth of the pension fund benefits 4.00% p.a. 4.00% p.a. Inflation 4.00% p.a. 4.00% p.a. Actuarial method Projected Unit Credit Projected Unit Credit (1) Determined based on market yield relating to National Treasury Notes (NTN-B) and compatible with the economic scenario observed on the balance sheet closing date, considering the volatility of interest market and models used. (2) Correspond to those disclosed by SOA – “Society of Actuaries”, by applying a 10% increase in the probabilities of survival regarding the respective basic tables. (3) Updated to the new expectation of mass behavior. Retired plans sponsored by foreign subsidiaries—Banco Itaú (Suisse) S.A., Itaú CorpBanca Colombia S.A. and PROSERV—Promociones y Servicios S.A. de C.V.—are structured as Defined Benefit modality and adopt actual assumptions adequate to masses of participants and the economic scenario of each country. b) Risk Management The EFPCs sponsored by ITAÚ UNIBANCO HOLDING are regulated by the National Council for Complementary Pension (CNPC) and PREVIC, has an Executive Board, Advisory and Tax Councils. Benefits offered have long-tem characteristics and the main factors involved in the management and measurement of their risks are financial risk, inflation risk and demographic risk. - Financial Risk – the actuarial liability is calculated by adopting a discount, which may differ from rates earned in investments. If real income from plan investments is lower than yield expected, this may give rise to a deficit. To mitigate this risk and assure the capacity to pay long-term benefits, the plans have a significant percentage of fixed-income securities pegged to the plan commitments, aiming at minimizing volatility and risk of mismatch between assets and liabilities. Additionally, adherence tests are carried out in financial assumptions to ensure their adequacy to obligations of respective plans. - Inflation risk – a large part of liabilities is pegged to inflation risk, making actuarial liabilities sensitive to increase in rates. To mitigate this risk, the same financial risks mitigation strategies are used. - Demographic Risk – plans that have any obligation actuarially assessed are exposed to demographic risk. In the event the mortality tables used are not adherent to the mass of plan participants, a deficit or surplus may arise in actuarial evaluation. To mitigate this risk, adherence tests to demographic assumptions are conducted to ensure their adequacy to liabilities of respective plans. For purposes of registering in the balance sheet the EFPCs that manage them, actuarial liabilities of plans use discount rate adherent to its asset portfolio and income and expense flows, according to a study prepared by an independent consulting company. The actuarial method used is the aggregate method, through which the plan costing is defined by the difference between its equity coverage and the current value of its future liabilities, observing the methodology established in the respective actuarial technical note. In the event deficit is verified in the concession period above the settlement limits set forth by the legislation in force, a debt agreement is entered into with the sponsor with financial guarantees. Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 94

c) Asset management The purpose of the management of the funds is the long-term balance between pension assets and liabilities with payment of benefits by exceeding actuarial goals (discount rate plus benefit adjustment index, established in the plan regulations). Below is a table with the allocation of assets by category, segmented into Quoted in an Active Market and Not Quoted in an Active Market: Types Fair value % Allocation 12/31/2020 12/31/2019 12/31/2020 12/31/2019 Fixed income securities 21,172 20,672 91.16% 90.93% Quoted in an active market 20,804 20,366 89.58% 89.59% Non quoted in an active market 368 306 1.58% 1.34% Variable income securities 1,387 1,392 5.97% 6.12% Quoted in an active market 1,378 1,384 5.93% 6.09% Non quoted in an active market 9 8 0.04% 0.03% Structured investments 82 65 0.35% 0.29% Quoted in an active market — 0.00% 0.00% Non quoted in an active market 82 65 0.35% 0.29% Real estate 506 529 2.18% 2.33% Loans to participants 78 74 0.34% 0.33% Total 23,225 22,732 100.00% 100.00% The defined benefit plan assets include shares of ITAÚ UNIBANCO HOLDING, its main parent company (ITAÚSA) and of subsidiaries of the latter, with a fair value of R$ 11 (R$ 11 at 12/31/2019), and real estate rented to group companies, with a fair value of R$ 410 (R$ 445 at 12/31/2019). d) Other post-employment benefits ITAÚ UNIBANCO HOLDING and its subsidiaries do not have additional liabilities related to post-employment benefits, except in cases arising from maintenance commitments assumed in acquisition agreements occurred over the years, as well as those benefits originated from court decision in the terms and conditions established, in which there is total or partial sponsorship of health care plan for a specific mass of former employees and their beneficiaries. Its costing is actuarially determined so as to ensure coverage maintenance. These plans are closed to new applicants. Assumptions for discount rate, inflation, mortality table and actuarial method are the same used for retirement plans. ITAÚ UNIBANCO HOLDING used the percentage of 4% p.a. for medical inflation and the percentage of 3% p.a. for aging factor, additionally considering, inflation rate of 4% p.a. Particularly in other post-employment benefits, there is medical inflation risk associated to increase in medical costs above expectation. To mitigate this risk, the same financial risks mitigation strategies are used. Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 95

e) Change in the net amount recognized in the balance sheet The net amount recognized in the Balance Sheet is limited by the asset ceiling and it is computed based on estimated future contributions to be realized by the sponsor, so that it represents the maximum reduction amount in the contributions to be made. 12/31/2020 Other post- BD and CV plans CD plans employment Total benefits Actuarial Recognized Pension plan Asset Recognized Recognized Net assets Asset ceiling Liabilities liabilities amount fund ceiling amount amount Amounts at the beginning of the period 22,732 (19,659) (3,761) (688) 1,475 (849) 626 (967) (1,029) Amounts recognized in income (1+2+3+4) 1,731 (1,578) (287) (134) 20 (65) (45) (76) (255) 1—Cost of current service—(80)—(80) — — (80) 2—Cost of past service—(1)—(1) — — (1) 3—Net interest (1) 1,731 (1,497) (287) (53) 112 (65) 47 (76) (82) 4—Other expenses (2) — — (92)—(92)—(92) Amounts recognized in stockholders´ equity—other comprehensive income (5+6+7) (75) (669) 406 (338) (41) (37) (78) 6 (410) 5—Effects on asset ceiling — 406 406—(37) (37)—369 6—Remeasurements (113) (588)—(701) (41)—(41) 6 (736) Changes in demographic assumptions—(11)—(11) — — (11) Changes in financial assumptions—13—13 ——12 25 Experience of the plan (3) (113) (590)—(703) (41)—(41) (6) (750) 7—Exchange variation 38 (81)—(43) — — (43) Other (8+9) (1,163) 1,244—81 — - 115 196 8—Benefits paid (1,244) 1,244 — ——115 115 9—Contributions and investments from sponsor 81 — 81 — — 81 Amounts at end of the period 23,225 (20,662) (3,642) (1,079) 1,454 (951) 503 (922) (1,498) Amount recognized in Assets (Note 18a) 82 503—585 Amount recognized in Liabilities (Note 18b) (1,161)—(922) (2,083) 12/31/2019 Other post- BD and CV plans CD plans employment Total benefits Actuarial Recognized Pension plan Asset Recognized Recognized Net assets Asset ceiling Liabilities liabilities amount fund ceiling amount amount Amounts at the beginning of the period 18,808 (15,447) (3,664) (303) 1,604 (939) 665 (282) 80 Amounts recognized in income (1+2+3+4) 1,769 (1,505) (355) (91) 49 (91) (42) (459) (592) 1—Cost of current service—(70)—(70) — — (70) 2—Cost of past service — — ——(418) (418) 3—Net interest (1) 1,769 (1,435) (355) (21) 151 (91) 60 (41) (2) 4—Other expenses (2) — — (102)—(102)—(102) Amounts recognized in stockholders´ equity—other comprehensive income (5+6+7) 3,249 (3,881) 258 (374) (178) 181 3 (261) (632) 5—Effects on asset ceiling — 384 384—176 176—560 6—Remeasurements 3,255 (3,907) (126) (778) (178) 5 (173) (261) (1,212) Changes in demographic assumptions — — — ——Changes in financial assumptions—(3,610)—(3,610) ——(123) (3,733) Experience of the plan (3) 3,255 (297) (126) 2,832 (178) 5 (173) (138) 2,521 7—Exchange variation (6) 26—20 — — 20 Other (8+9) (1,094) 1,174—80 ——35 115 8—Benefits paid (1,174) 1,174 — ——35 35 9—Contributions and investments from sponsor 80 — 80 — — 80 Amounts at end of the period 22,732 (19,659) (3,761) (688) 1,475 (849) 626 (967) (1,029) Amount recognized in Assets (Note 18a) 91 626—717 Amount recognized in Liabilities (Note 18b) (779)—(967) (1,746) (1) Corresponds to the amount calculated on 01/01/2020 based on the initial amount (Net Assets, Actuarial Liabilities and Restriction of Assets), taking into account the estimated amount of payments/ receipts of benefits/ contributions, multiplied by the discount rate of 7.64% p.a.(At 01/01/2019 the rate used was 9.72% p.a.). (2) Corresponds to the use of asset amounts allocated in pension funds of the defined contribution plans. (3) Correspond to the income obtained above/below the expected return and comprise the contributions made by participants. Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 96

f) Defined benefit contribution Estimated Contributions made contribution 2021 01/01 to 12/31/2020 01/01 to 12/31/2019 Retirement plan—FIU 47 45 45 Retiremente plan—FUNBEP 3 5 8 Total 50 50 53 g) Maturity profile of defined benefit liabilities Duration (*) 2021 2022 2023 2024 2025 2026 to 2030 Pension plan—FIU 11.65 882 915 949 985 1,021 5,595 Pension plan—FUNBEP 10.51 457 472 488 503 517 2,757 Other post-employment benefits 9.51 124 125 136 131 35 198 Total 1,463 1,512 1,573 1,619 1,573 8,550 (*) Average duration of plan´s actuarial liabilities. h) Sensitivity analysis To measure the effects of changes in the key assumptions, sensitivity tests are conducted in actuarial liabilities annually. The sensitivity analysis considers a vision of the impacts caused by changes in assumptions, which could affect the income for the period and stockholders’ equity at the balance sheet date. This type of analysis is usually carried out under the ceteris paribus condition, in which the sensitivity of a system is measured when only one variable of interest is changed and all the others remain unchanged. The results obtained are shown in the table below: BD and CV plans Other post-employment benefits Stockholders´ Stockholders´ Present value equity (Other Present value of equity (Other Main assumptions Income Income of liability Comprehensive liability Comprehensive Income) (*) Income) (*) Discount rate Increase by 0.5% (1,019)—346 (39)—39 Decrease by 0.5% 1,116—(533) 44—(44) Mortality table Increase by 5% (281)—94 (14)—14 Decrease by 5% 295—(99) 15—(15) Medical inflation Increase by 1% ——101—(101) Decrease by 1% ——(81)—81 (*) Net of effects of asset ceiling Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 97

Note 27 – Insurance contracts and private pension ITAÚ UNIBANCO HOLDING, through its subsidiaries, offers to the market insurance and private pension products, with the purpose of assuming risks and restoring the economic balance of the insured’s assets. Products are offered through insurance brokers (independent and captive brokers), Itaú Unibanco’s electronic channels and branches, in compliance with the regulatory requirements, of the National Council of Private Insurance – CNSP and the Superintendence of Private Insurance—SUSEP. I – Insurance A contract entered into by the parties to protect the customer’s assets, upon payment of a premium, by means of replacement or pre-established financial compensation, against damage their property or their person. As backing, ITAÚ UNIBANCO HOLDING insurance companies set up technical reserves, through specialized areas within the conglomerate, with the objective of indemnifying policyholders’ losses in the event of claims of insured risks. The insurance risks sold by ITAÚ UNIBANCO HOLDING’s insurance companies are divided into property and casualty insurance, covering loss, damage or liabilities for assets or persons, and life insurance that includes coverage for death and personal accidents. II – Private pension Designed to ensure the maintenance of the quality of life of participants, as a supplement to the government plans, through long term investments, private pension products are divided into three major groups: · PGBL – Free Benefit Generating Plan: The main objective of this plan is the accumulation of financial resources, but it can be purchased with additional risk coverage. Recommended for customers that file the full version of the income tax return, because they can deduct contributions paid for tax purposes up to 12% of their annual taxable gross income; · VGBL—Free Benefit Generating Life Plan: This is insurance structured as a pension plan. Its taxation differs from the PGBL; in this case, the tax basis is the earned income; and · FGB – Benefit Generating Fund: This is a pension plan with minimum income guarantee, and possibility of receiving earnings from asset performance. Although there are plans still in existence, they are no longer sold. III – Technical provision for insurance and private pensions The technical provisions for insurance and private pensions are recognized according to the technical notes approved by SUSEP and criteria established by current legislation, as follows: · Provision for unearned premiums (PPNG) - this provision is recognized, based on insurance premiums, to cover amounts payable for future claims and expenses. In the calculation, the term to maturity of risks assumed and issued and risks in effect but not issued (PPNG-RVNE) in the policies or endorsements of contracts in force is taken pro rata on a daily basis; · Provision for unsettled claims (PSL)—this provision is recognized to cover expected amounts for reported and unpaid claims, including administrative and judicial claims. It includes amounts related to indemnities, reserve funds and past-due income, all gross of reinsurance operations and net of coinsurance operations, when applicable. When necessary, it must cover adjustments for IBNER (claims incurred but not sufficiently reported) for the total of claims reported but not yet paid, a total which may change during the process up to final settlement; · Provision for claims incurred and not reported (IBNR)—this provision is recognized for the coverage of expected amount for settlement of claims incurred but not reported up to the calculation base date, including administrative and judicial claims. It includes amounts related to indemnities, reserve funds and income, all gross of reinsurance operations and net of coinsurance operations; · Mathematical provisions for benefits to be granted (PMBAC) - recognized for the coverage of commitments assumed to participants or policyholders, based on the provisions of the contract, while the event that gives rise to the benefit and/or indemnity has not occurred; Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 98

· Mathematical provisions for benefits granted (PMBC) - recognized for the coverage of commitments to payment of indemnities and/or benefits to participants or insured parties, based on the provisions of the contract, after the event has occurred; · Provision for financial surplus (PEF)—it is recognized to guarantee amounts intended for the distribution of financial surplus, if provided for in the contract. Corresponds to the financial income exceeding the minimum return guaranteed in the product; · Supplemental Coverage Reserve (PCC)—recognized when technical reserves are found to be insufficient, as shown by the Liability Adequacy Test, provided for in the regulations; · Provision for redemptions and other amounts to be regularized (PVR)—this provision is recognized for the coverage of amounts related to redemptions to be regularized, returned premiums or funds, transfers requested but, for any reason, not yet transferred to the recipient insurance company or open private pension entity, and where premiums have been received but not quoted; · Provision for related expenses (PDR)—recognized for the coverage of expected amounts related to expenses on benefits and indemnities, due to events which have occurred or will occur. IV—Main information related to Insurance and Private Pension operations a) Indexes Sales ratio Loss ratio % % Main Insurance Lines 01/01 to 01/01 to 01/01 to 01/01 to 01/01 to 01/01 to 12/31/2020 12/31/2019 12/31/2018 12/31/2020 12/31/2019 12/31/2018 Group Accident Insurance 33.8 35.1 34.3 11.3 6.8 9.4 Individual Accident Insurance 18.8 18.8 14.1 29.4 24.1 20.8 Credit Life Insurance 24.2 23.7 20.4 22.3 18.0 18.3 Random Events 23.5 23.5 20.3 34.3 26.3 17.1 Multiple Peril 44.4 46.4 48.1 52.9 60.2 53.3 Mortagage Insurance in Market Policies – Credit Life Insurance 20.4 20.0 20.4 18.5 17.3 15.3 Group Life 24.0 23.2 15.1 41.0 34.4 33.2 b) Revenues from insurance premiuns and private pension Premiums and contributions Main lines 01/01 to 01/01 to 01/01 to 12/31/2020 12/31/2019 12/31/2018 Group Accident Insurance 847 867 689 Individual Accident Insurance 187 222 280 Disability Savings Pension 258 269 291 PGBL 2,235 2,282 2,193 Credit Life Insurance 624 946 879 Random Events 195 227 235 Multiple Peril 370 290 209 Mortagage Insurance in Market Policies – Credit Life Insurance 339 324 288 Traditional 117 115 122 VGBL 8,022 12,335 17,154 Group Life 955 947 937 Other lines 655 800 820 Total 14,804 19,624 24,097 Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 99

c) Technical provisions balances 12/31/2020 12/31/2019 Insurance Private Pension Total Insurance Private Pension Total Unearned premiums (PPNG) 2,298 12 2,310 2,343 13 2,356 Mathematical provisions for benefits to be granted (PMBAC) and granted benefits (PMBC) 17 215,216 215,233 204 212,274 212,478 Redemptions and Other Unsettled Amounts (PVR) 16 332 348 13 318 331 Financial surplus (PEF) 2 655 657 2 610 612 Unsettled claims (PSL) 515 68 583 571 47 618 Claims / events incurred but not reported (IBNR) 294 22 316 277 22 299 Related Expenses (PDR) 29 88 117 28 89 117 Other provisions 132 1,304 1,436 250 1,273 1,523 Total 3,303 217,697 221,000 3,688 214,646 218,334 Current 2,537 526 3,063 2,613 493 3,106 Non-current 766 217,171 217,937 1,075 214,153 215,228 d) Change in technical provisions 12/31/2020 12/31/2019 Private Private Insurance Total Insurance Total pension pension Opening balance—01/01 3,688 214,646 218,334 3,809 197,378 201,187 (+) Additions arising from premiums / contributions 4,176 10,389 14,565 4,634 14,735 19,369 (-) Deferral due to elapsed risk (4,221)—(4,221) (4,216)—(4,216) (-) Payment of claims / benefits (1,263) (364) (1,627) (1,349) (566) (1,915) (+) Reported claims 1,322—1,322 1,465—1,465 (-) Redemptions—(15,431) (15,431)—(15,623) (15,623) (+/-) Net Portability—563 563—1,754 1,754 (+) Adjustment of reserves and financial surplus 12 7,837 7,849 10 16,507 16,517 (+/-) Other (increase / reversal) (190) 57 (133) (665) 461 (204) (+/-) Corporate Reorganization (221)—(221) ——Closing balance 3,303 217,697 221,000 3,688 214,646 218,334 Through actuarial models based mainly on the portfolio historical experience and on macroeconomic projections, ITAÚ UNIBANCO HOLDING establishes the assumptions that influence the assessment of technical provisions. The assumptions are reassessed annually by experts of the actuarial and risk area, and are subsequently submitted to the executive’s approval. The effects on assumptions are recognized in income for the period in which they occurred. Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 100

V—Deferred acquisition costs They are recorded in assets and charges are shown in the table below: 12/31/2020 12/31/2019 Opening Balance—01/01 495 409 Increase 1,089 1,156 Amortization (1,088) (1,070) Closing Balance 496 495 Balance to be amortized in up to 12 months 380 389 Balance to be amortized after 12 months 116 106 VI—Table of Claims Development Provision for unsettled claims (PSL) 583 (-) IBNER 245 (-) Reinsurance 20 (-) Retrocession and other estimates (19) Liability claims presented in the claims development table (a + b) 337 The amount of obligations of the ITAÚ UNIBANCO HOLDING may change. The first part of the table shows how the final loss estimate changes through time. The second part of the table reconciles the amounts pending payment and the liability disclosed in the balance sheet. a) Administratives claims—net of reinsurance Occurrence date 12/31/2016 12/31/2017 12/31/2018 12/31/2019 12/31/2020 Total At the end of reporting period 938 934 993 1,149 1,222 After 1 year 981 977 1,012 1,132 After 2 years 1,001 975 1,014 After 3 years 1,078 973 After 4 years 1,075 Current estimate 1,075 973 1,014 1,132 1,222 Accumulated payments through base date 1,058 960 1,000 1,117 1,122 5,257 Liabilities recognized in the balance sheet 17 13 14 15 100 159 Liabilities in relation to prior periods 26 Total administratives claims 185 b) Judicial claims—net of reinsurance Occurrence date 12/31/2016 12/31/2017 12/31/2018 12/31/2019 12/31/2020 Total At the end of reporting period 26 28 16 20 12 After 1 year 35 40 33 36 After 2 years 43 51 47 After 3 years 55 60 After 4 years 63 Current estimate 63 60 47 36 12 Accumulated payments through base date 52 50 35 25 4 166 Liabilities recognized in the balance sheet 11 10 12 11 8 52 Liabilities in relation to prior periods 100 Total judicial claims 152 The breakdown of the claims development table into administrative and judicial shows the reallocation of admininstrative claims up to a certain base date and that become judicial claims afterwards, which may give the wrong impression of need for adjusting the provisions in each breakdown. Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 101

VII—Liability Adequacy Test ITAÚ UNIBANCO HOLDING tests for Liability Adequacy semiannually, by comparing the amount recognized for its technical reserves with the current estimate of cash flow of its future obligations. The estimate should include all cash flows related to the business, which is the minimum requirement for carrying out the adequacy test. The Liability Adequacy Test did not indicate significant insufficiency in 2020, 2019 and 2018. The assumptions used in the test are periodically reviewed and are based on best practices and an analysis of subsidiaries’ experience, thus representing the best estimates for cash flow projections. Methodology and test grouping Specifically for insurance products, cash flows were projected using the method known as the run-off triangle for quarterly frequency periods. For pension products, cash flows for the deferral and concession phases are tested separately. The risk grouping criteria include groups subject to similar risks that are jointly managed as a single portfolio. Demographic tables Demographic tables are instruments to measure the demographic risk represented by the probability of death, survival or disability of a participant. For death and survival estimates, the latest Brazilian Market Insurer Experience tables (BR-EMS) are used, adjusted according to Scale G life expectancy development, and the Álvaro Vindas table is used to estimate benefit requests for disability. Risk-free interest rate The relevant risk-free forward interest-rate structure (ETTJ) is an indicator of the pure time value of money used to price the set of projected cash flows. The ETTJ was obtained from the curve of securities deemed to be credit risk free, available in the Brazilian financial market and determined by ITAÚ UNIBANCO HOLDING using its own method, plus a spread, which takes into account the impact of the market result of securities classified as Financial assets at amortized cost in the Guarantee assets portfolio. Annuity conversion rate The annuity conversion rate represents the expected conversion of balances accumulated by participants in retirement benefits. The decision by participants convert into an annuity is influenced by behavioral, economic and tax factors. Other assumptions Related expenses, cancellations and partial redemptions, future additions and contributions, are among the assumptions that affect the estimate of projected cash flows since they represent expenses and income arising from insurance agreements assumed. Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 102

Note 28 – Fair value of financial instruments In cases where market prices are not available, fair values are based on estimates using discounted cash flows or other valuation techniques. These techniques are significantly affected by the assumptions adopted, including the discount rate and estimate of future cash flows. The estimated fair value obtained through these techniques cannot be substantiated by comparison with independent markets and, in many cases, cannot be achieved on immediate settlement of the instrument. The following table summarizes the book values and estimated fair values for financial instruments: 12/31/2020 12/31/2019 Book value Fair value (*) Book value Fair value Cash (a) 46,224 46,224 30,367 30,367 Financial assets 1,851,322 1,861,146 1,501,481 1,513,562 At Amortized Cost 1,275,799 1,285,623 1,101,892 1,113,973 Central Bank compulsory deposits (a) 90,059 90,059 91,248 91,248 Interbank deposits (b) 55,685 55,883 34,583 34,622 Securities purchased under agreements to resell (a) 239,943 239,943 198,428 198,428 Securities (c) 129,804 131,159 133,119 135,891 Loan and Financial Lease (d) 714,104 722,375 585,791 595,061 Other financial assets (e) 93,255 93,255 94,752 94,752 (-) Provision for Expected Loss (47,051) (47,051) (36,029) (36,029) At Fair Value Through Other Comprehensive Income 109,942 109,942 76,660 76,660 Securities (c) 109,942 109,942 76,660 76,660 At Fair Value Through Profit or Loss 465,581 465,581 322,929 322,929 Securities (c) 389,071 389,071 281,075 281,075 Derivatives (c) 76,504 76,504 41,854 41,854 Other financial assets 6 6 — Financial liabilities 1,579,686 1,581,953 1,211,999 1,214,196 At Amortized Cost 1,495,641 1,497,908 1,159,830 1,162,027 Deposits (b) 809,010 808,965 507,060 507,110 Securities sold under repurchase agreements (a) 273,364 273,364 256,583 256,583 Interbank market funds (b) 156,035 156,106 174,862 174,949 Institutional market funds (b) 138,308 140,549 104,244 106,304 Other financial liabilities (e) 118,924 118,924 117,081 117,081 At Fair Value Through Profit or Loss 79,653 79,653 48,029 48,029 Derivatives (c) 79,505 79,505 47,828 47,828 Structured notes 143 143 201 201 Other financial liabilities 5 5 — Provision for Expected Loss 4,392 4,392 4,140 4,140 Loan Commitments 3,485 3,485 3,303 3,303 Financial Guarantees 907 907 837 837 (*) In the period, the result of Derivatives, as well as Adjustment to Fair Value of Financial Assets (particularly private securities) had their amounts affected by oscillations of rates and other market variables arising from the impact of the COVID-19 pandemic on the macroeconomic scenario in the period (Note 33a). Financial instruments not included in the Balance Sheet (Note 32) are represented by Standby letters of credit and financial guarantees provided, which amount to R$ 110,410 (R$ 81,733 at 12/31/2019) with an estimated fair value of R$ 520 (R$ 968 at 12/31/2019). Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 103

The methods and assumptions used to estimate the fair value are defined below: a) Cash, Central Bank compulsory deposits, Securities purchased under agreements to resell and Securities sold under repurchase agreements – The carrying amounts for these instruments are close to their fair values. b) Interbank deposits, Deposits, Interbank and Institutional Market Funds – they are calculated by discounting estimated cash flows at market interest rates. c) Securities and Derivatives – Under normal conditions, the prices quoted in the market are the best indicators of the fair values of these financial instruments. However, not all instruments have liquidity or quoted market prices and, in such cases, it is necessary to adopt present value estimates and other techniques to establish their fair value. In the absence of prices quoted by the Brazilian Association of Financial and Capital Markets Entities (ANBIMA), the fair values of government securities are determined based on the interest rates provided by brokers. The fair values of corporate securities are calculated by discounting estimated cash flows at market interest rates. The fair values of shares are based on the prices quoted in the market. The fair values of derivative financial instruments were determined as follows: · Swaps: The cash flows are discounted to present value based on yield curves that reflect the appropriate risk factors, mainly following swap prices on B3 for derivatives, of Brazilian government securities in the secondary market or derivatives and securities traded abroad. These yield curves may be used to obtain the fair value of currency swaps, interest rate swaps and swaps based on other risk factors (commodities, stock exchange indices, etc.). · Futures and forwards: Quotations on exchanges or using criteria identical to those applied to swaps. · Options: Determined through mathematical models, such as Black-Scholes, using data, in general from Bloomberg, for implicit volatility, interest rate yield curve and fair value of the underlying asset. Current market prices of options are used to compute the implicit volatilities. · Credit Derivatives: They are inversely related to the probability of default (PD) in a financial instrument subject to credit risk. The process of adjusting the market price of these spreads is based on the differences between the yield curves with and without credit risk. d) Loans and financial leases – Fair value is estimated for groups of loans with similar financial and risk characteristics, using valuation models. The fair value of fixed-rate loans was determined by discounting estimated cash flows, at interest rates applicable to similar loans. For the majority of loans at floating rates, the carrying amount was considered to be close to their market value. The fair value of loan and lease operations not overdue was calculated by discounting the expected payments of principal and interest to maturity. The fair value of overdue loan and lease transactions was based on the discount of estimated cash flows, using a rate proportional to the risk associated with the estimated cash flows, or on the underlying collateral. The assumptions for cash flows and discount rates rely on information available in the market and knowledge of the individual debtor. e) Other financial assets / liabilities – primarily composed of receivables from credit card issuers, deposits in guarantee for contingent liabilities, provisions and legal obligations and trading and intermediation of securities. The carrying amounts for these assets/liabilities substantially approximate to their fair values, since they principally represent amounts to be received in the short term from credit card holders and to be paid to credit card issuers, deposits in guarantee (indexed to market rates) made by ITAÚ UNIBANCO HOLDING to secure lawsuits or very short-term receivables (generally with a maturity of approximately 5 business days). All of these items represent assets / liabilities without significant associated market, credit or liquidity risks. Level 1: Observable inputs that reflect quoted prices (unadjusted) for identical assets or liabilities in active markets. An active market is a market in which transactions for the asset or liability being measured occur often enough and with sufficient volume to provide pricing information on an ongoing basis. Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 104

Level 2: Input that is not observable for the asset or liability either directly or indirectly. Level 2 generally includes: (i) quoted prices for similar assets or liabilities in active markets; (ii) quoted prices for identical or similar assets or liabilities in markets that are not active, that is, markets in which there are few transactions for the asset or liability, the prices are not current, or quoted prices vary substantially either over time or among market makers, or in which little information is released publicly; (iii) inputs other than quoted prices that are observable for the asset or liability (for example, interest rates and yield curves observable at commonly quoted intervals, volatilities, etc.); (iv) inputs that are mainly derived from or corroborated by observable market data through correlation or by other means. Level 3: Inputs are not observable for the asset or liability. Unobservable information is used to measure fair value to the extent that observable information is not available, thus allowing for situations in which there is little, or no market activity for the asset or liability at the measurement date. Financial assets at fair value through profit or loss, including Derivatives, and at fair value through other comprehensive income: Level 1: Highly-liquid securities with prices available in an active market and derivatives traded on stock exchanges. This classification level includes most of the Brazilian government securities, other foreign government securities, shares and debentures traded on stock exchanges and other securities traded in an active market. Level 2: When pricing information is not available for a specific security, valuation is usually based on prices quoted in the market for similar instruments, pricing information obtained from pricing services, such as Bloomberg, Reuters and brokers (only when the prices represent actual transactions) or discounted cash flows, which use information for assets actively traded in an active market. These securities are classified at Level 2 of the fair value hierarchy and consist of certain Brazilian government securities, debentures, some government securities quoted in a less liquid market than for Level 1, and some share prices in investment funds. Derivatives included in Level 2 are credit default swaps, cross-currency swaps, interest rate swaps, simple options and some forwards, since information adopted by pricing models is immediately observable in actively quoted markets. The models used for these instruments are Black-Scholes, Garman & Kohlhagen, Monte Carlo and discounted cash flow. ITAÚ UNIBANCO HOLDING does not hold positions in alternative investment funds or private equity funds. Level 3: When there is no pricing information in an active market, ITAÚ UNIBANCO HOLDING uses internally developed models, from curves generated according to a proprietary model. Level 3 classification includes some Brazilian government and corporate securities falling due after 2025 which are not usually traded in an active market. Derivatives with fair values classified in Level 3 of the fair value hierarchy are composed of exotic options, certain swaps indexed to non-observable inputs, and swaps with other products, such as swap with options or with verification, credit derivatives and futures of certain commodities. All the above methods may result in a fair value that is not indicative of the net realizable value or future fair values. However, ITAÚ UNIBANCO HOLDING believes that all the method used are appropriate and consistent with other market participants. Moreover, the adoption of different methods or assumptions to estimate fair value may result in different fair value estimates at the balance sheet date. Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 105

Distribution by level The following table presents the breakdown of fair value hierarchy levels. 12/31/2020 12/31/2019 Level 1 Level 2 Level 3 Total Level 1 Level 2 Level 3 Total Financial assets at fair value through profit or loss 312,572 70,791 1,968 385,331 234,583 43,738 1,719 280,040 Investment funds 576 13,628—14,204 318 7,949—8,267 Brazilian government securities 279,180 6,705—285,885 216,167 3,444—219,611 Government securities – other countries 8,210 — 8,210 1,520 — 1,520 Argentina 1,498 — 1,498 318 — 318 Chile 840 — 840 488 — 488 Colombia 3,603 — 3,603 409 — 409 United States 2,085 — 2,085 141 — 141 Italy 130 — 130 — — Mexico 5 — 5 57 — 57 Paraguay 3 — 3 2 — 2 Peru 5 — 5 8 — 8 Uruguay 41 — 41 97 — 97 Corporate securities 24,606 50,458 1,968 77,032 16,578 32,345 1,719 50,642 Shares 14,176 4,871—19,047 9,847 4,790—14,637 Rural product note—2,285 64 2,349 — — Bank deposit certificates—729—729—792—792 Real estate receivables certificates — 548 548 — 1,444 1,444 Debentures 7,962 20,625 1,350 29,937 4,667 7,763 225 12,655 Eurobonds and others 2,383 — 2,383 2,064 102 7 2,173 Financial bills—15,777 6 15,783—18,501 13 18,514 Promissory notes—5,616—5,616—313—313 Other 85 555—640—84 30 114 Other Financial Assets—6—6 — —Financial assets at fair value through other comprehensive income 84,239 25,703—109,942 72,455 4,171 34 76,660 Brazilian government securities 66,701 1,248—67,949 49,879 853—50,732 Government securities – other countries 12,751 21,651—34,402 20,571 — 20,571 Germany — — 23 — 23 Chile—21,651—21,651 11,208 — 11,208 Colombia 3,986 — 3,986 3,878 — 3,878 United States 3,750 — 3,750 2,756 — 2,756 Italy — — 329 — 329 Mexico 1,181 — 1,181 — — Paraguay 2,947 — 2,947 1,780 — 1,780 Uruguay 887 — 887 597 — 597 Corporate securities 4,787 2,804—7,591 2,005 3,318 34 5,357 Shares 1,382 — 1,382 149 — 149 Bank deposit certificates—307—307—2,371—2,371 Real estate receivables certificates — — — 26 26 Debentures 419 470—889 334 — 334 Eurobonds and others 2,986 2,027—5,013 1,522 947 8 2,477 Financial assets designated at fair value through profit or loss 3,740 — 3,740 1,035 — 1,035 Brazilian external debt bonds 3,740 — 3,740 1,035 — 1,035 Financial liabilities at fair value through profit or loss—5—5 — — Other financial liabilities—5—5 — — Financial liabilities designated at fair value through profit or loss—143—143—201—201 Structured notes—143—143—201—201 The following table presents the breakdown of fair value hierarchy levels for derivative assets and liabilities. 12/31/2020 12/31/2019 Level 1 Level 2 Level 3 Total Level 1 Level 2 Level 3 Total Assets 23 76,376 105 76,504 14 41,737 103 41,854 Swap Contracts – adjustment receivable—45,926 93 46,019—26,426 32 26,458 Option Contracts 4 20,402 12 20,418—8,385 71 8,456 Forward Contracts—2,085—2,085—2,162—2,162 Credit derivatives—156—156—167—167 NDF—Non Deliverable Forward—7,596—7,596—4,446—4,446 Other derivative financial instruments 19 211—230 14 151—165 Liabilities (22) (79,373) (110) (79,505) (7) (47,736) (85) (47,828) Swap Contracts – adjustment payable—(51,680) (109) (51,789)—(32,881) (46) (32,927) Option Contracts (13) (20,248) (1) (20,262)—(9,022) (39) (9,061) Forward Contracts—(905)—(905)—(754)—(754) Credit derivatives—(76)—(76)—(40)—(40) NDF—Non Deliverable Forward—(6,426)—(6,426)—(4,971)—(4,971) Other derivative financial instruments (9) (38)—(47) (7) (68)—(75) There were no significant transfer between Level 1 and Level 2 during the periods of 12/31/2020 and 12/31/2019. Transfers to and from Level 3 are presented in movements of Level 3. Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 106

Measurement of Level 2 fair value based on pricing services and brokers To ensure that the fair value of these instruments is properly classified as Level 2, in-house analysis of information received are conducted, so as to understand the nature of the inputs used by the service provider. Prices provided by pricing services that meet the following requirements are considered Level 2: input is immediately available, regularly distributed, provided by sources actively involved in significant markets and it is not proprietary. For financial instruments classified as Level 2, the pricing service or brokers were used to price securities substantially represented by: · Debentures: When available, we use price information for transactions recorded in the Brazilian Debenture System (SND), an electronic platform operated by B3, which provides multiple services for transactions involving debentures in the secondary market. Alternatively, prices of debentures provided by ANBIMA are used. Its methodology includes obtaining, on a daily basis, illustrative non-binding prices from a group of market players deemed to be significant. Such information is subject to statistical filters intended to eliminate outliers. · Financial Bills: In order to mark Financial Bills to market, it is necessary to calculate its future value by projecting the notional issue value and its yields established by contract (fixed rate, floating rate or price index) and discounting the fixed curve in reais, obtained through DI Futures prices traded on B3. · Global and corporate securities: The pricing process for these securities consists of capturing from 2 to 8 quotes from Bloomberg, depending on the asset. The method then compares the highest purchase prices and the lowest sale prices of trades provided by Bloomberg for the last day of the month. These prices are compared with information from purchase orders that the Institutional Treasury of ITAÚ UNIBANCO HOLDING provides to Bloomberg. Should the difference between them be lower than 0.5%, the average price of Bloomberg is used. If it is higher than 0.5% or if the Institutional Treasury does not provide information on this specific security, the average price gathered directly from other banks is used. The Institutional Treasury price is used as a reference only and never in the computation of the final price. Level 3 recurring fair value measurements The departments in charge of defining and applying the pricing models are segregated from the business areas. The models are documented, submitted to validation by an independent area and approved by a specific committee. The daily process of price capture, calculation and disclosure is periodically checked according to formally defined tests and criteria and the information is stored in a single corporate data base. The most frequent cases of assets classified as Level 3 are justified by the discount factors used. Factors such as the fixed interest curve in Brazilian Reais and the TR coupon curve – and, as a result, their related factors – have inputs with terms shorter than the maturities of fixed-income assets. For swaps, the indexers for both legs are analyzed. There are some cases in which the input periods are shorter than the maturity of the derivative. Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 107

Level 3 recurring fair value changes The tables below show balance sheet changes for financial instruments classified by ITAÚ UNIBANCO HOLDING in Level 3 of the fair value hierarchy. Derivative financial instruments classified in Level 3 correspond to other derivatives indexed to shares. Total gains or losses (realized / unrealized) Transfers in Fair value Fair value at Total Gains or Recognized in Purchases Settlements and / or out of at 12/31/2019 Losses (Unrealized) Recognized in other Level 12/31/2020 income comprehensive income Financial assets at fair value through profit or 1,719 (1,160)—1,619 (779) 569 1,968 (700) loss Corporate securities 1,719 (1,160)—1,619 (779) 569 1,968 (700) Real estate receivables certificates 1,444 (726)—263 (433)—548 (14) Debentures 225 (369)—1,050 (272) 716 1,350 (635) Rural Product Note—(55)—227 (19) (89) 64 (51) Eurobonds and other 7 (6)—69 (12) (58) — Financial bills 13 (2) — (5)—6—Other 30 (2)—10 (38) ——Financial assets at fair value through other 34 7 (6) 248 (167) (116) —comprehensive income Corporate securities 34 7 (6) 248 (167) (116) — Real estate receivables certificates 26 ——(26) ——Eurobonds and other 8 7 (6) 248 (141) (116) — Total gains or losses (realized / unrealized) Transfers in Fair value Fair value at Recognized in Total Gains or Purchases Settlements and / or out of at 12/31/2019 Recognized in other Losses (Unrealized) income comprehensive Level 12/31/2020 income Derivatives—assets 103 89—193 (234) (46) 105 51 Swap Contracts – adjustment receivable 32 107—10 (11) (45) 93 91 Option Contracts 71 (18)—183 (223) (1) 12 (40) Derivatives—liabilities (85) (93)—(130) 177 21 (110) (90) Swap Contracts – adjustment payable (46) (74)—(12) 1 22 (109) (90) Option Contracts (39) (19)—(118) 176 (1) (1)—Total gains or losses (realized / unrealized) Transfers in Fair value at Recognized in Fair value at Total Gains or Purchases Settlements and / or out of 12/31/2018 Recognized in other 12/31/2019 Losses (Unrealized) income comprehensive Level income Financial assets at fair value through profit or 2,833 (1,300)—1,755 (907) (662) 1,719 (307) loss Corporate securities 2,833 (1,300)—1,755 (907) (662) 1,719 (307) Shares 1,268 (285) ——(983) — Real estate receivables certificates 1,411 (487)—573 (53)—1,444 29 Debentures 85 (504)—604 (222) 262 225 (336) Eurobonds and other 31 (4)—3 (51) 28 7—Financial bills 5 6—8 (6)—13—Other 33 (26)—567 (575) 31 30—Financial assets designated at fair value—43 (47) 76 (68) 30 34 (2) through other comprehensive income Corporate securities—43 (47) 76 (68) 30 34 (2) Real estate receivables certificates ——26 — 26—Debentures—(2) 6 50 (54) — 1 Eurobonds and other—45 (53)—(14) 30 8 (3) Total gains or losses (realized / unrealized) Transfers in Fair value at Fair value at Total Gains or Recognized in Purchases Settlements and / or out of 12/31/2018 12/31/2019 Losses (Unrealized) Recognized in other Level income comprehensive income Derivatives—Assets 142 (78)—274 (156) (79) 103 (1) Swap Contracts – adjustment receivable 90 21—2 (2) (79) 32 31 Option Contracts 52 (99)—272 (154)—71 (32) Derivatives—Liabilities (26) (17)—(196) 172 (18) (85) (2) Swap Contracts – adjustment payable (3) (51)—(10) 36 (18) (46) (17) Option Contracts (23) 34—(186) 136—(39) 15 Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 108

Sensitivity analysis of Level 3 operations The fair value of financial instruments classified in Level 3 is measured through valuation techniques based on correlations and associated products traded in active markets, internal estimates and internal models. Significant unobservable inputs used for measurement of the fair value of instruments classified in Level 3 are: interest rates, underlying asset prices and volatility. Significant variations in any of these inputs separately may give rise to substantial changes in the fair value. The table below shows the sensitivity of these fair values in scenarios of changes of interest rates or, asset prices, or in scenarios with varying shocks to prices and volatilities for nonlinear assets: Sensitivity – Level 3 Operations 12/31/2020 12/31/2019 Impact Impact Market risk factor groups Scenarios Stockholders’ Stockholders’ Income Income equity equity I (0.8)—(0.9) (0.0) Interest rates II (19.8)—(23.3) (0.3) III (38.2)—(46.1) (0.6) I — —Commodities, Index and Shares II — —I (8.3)—(22.6) -Nonlinear II (11.6)—(43.2)—The following scenarios are used to measure sensitivity: Interest rate Based on reasonably possible changes in assumptions of 1, 25 and 50 basis points (scenarios I, II and III respectively) applied to the interest curves, both up and down, taking the largest losses resulting in each scenario. Commodities, Index and Shares Based on reasonably possible changes in assumptions of 5 and 10 percentage points (scenarios I and II respectively) applied to share prices, both up and down, taking the largest losses resulting in each scenario. Nonlinear Scenario I: Based on reasonably possible changes in assumptions of 5 percentage points on prices and 25 percentage points on the volatility level, both up and down, taking the largest losses resulting in each scenario. Scenario II: Based on reasonably possible changes in assumptions of 10 percentage points on prices and 25 percentage points on the volatility level, both up and down, taking the largest losses resulting in each scenario. Note 29—Contingent Assets and Liabilities, Provisions and Legal Obligations In the ordinary course of its business, ITAÚ UNIBANCO HOLDING may be a party to legal proceedings to labor, civil and tax nature. The contingencies related to these lawsuits are classified as follows: a) Contingent Assets: There are no contingent assets recorded. b) Provisions and contingencies: The criteria to quantify of provisions for contingencies are adequate in relation to the specific characteristics of civil, labor and tax lawsuits portfolios, as well as other risks, taking into consideration the opinion of its legal advisors, the nature of the lawsuits, the similarity with previous lawsuits and the prevailing previous court decisions. A provision is recognized whenever the loss is classified as probable. Legal liabilities arise from lawsuits filed to discuss the legality and unconstitutionality of the legislation in force, being subject to an accounting provision. Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 109

I- Civil lawsuits In general, provisions and contingencies arise from claims related to the revision of contracts and compensation for material and moral damages. The lawsuits are classified as follows: Collective lawsuits: Related to claims of a similar nature and with individual amounts that are not considered significant. Provisions are calculated on a monthly basis and the expected amount of losses is accrued according to statistical references that take into account the nature of the lawsuit and the characteristics of the court (Small Claims Court or Regular Court). Contingencies and provisions are adjusted to reflect the amounts deposited into court as guarantee for their execution when realized. Individual lawsuits: Related to claims with unusual characteristics or involving significant amounts. The probability of loss is ascertained periodically, based on the amount claimed and the special nature of each case. The amounts considered as probable losses are recorded as provisions. ITAÚ UNIBANCO HOLDING, despite having complied with the rules in force at the time, is a defendant in lawsuits filed by individuals referring to payment of inflation adjustments to savings accounts resulting from economic plans implemented in the 1980s and the 1990s, as well as in collective lawsuits filed by: (i) consumer protection associations; and (ii) the Public Attorney’s Office, on behalf of the savings accounts holders. ITAÚ UNIBANCO HOLDING recognizes provisions upon receipt of summons, and when individuals demand the enforcement of a ruling handed down by the courts, using the same criteria as for provisions for individual lawsuits. The Federal Supreme Court (STF) has issued some decisions favorable to savings account holders, but it has not established its understanding with respect to the constitutionality of the economic plans and their applicability to savings accounts. Currently, the appeals involving these matters are suspended, by order of the STF, until it pronounces its final decision. In December 2017, through mediation of the Federal Attorney’s Office (AGU) and supervision of the BACEN, savers (represented by two civil associations, FEBRAPO and IDEC) and FEBRABAN entered into an instrument of agreement aiming at resolving lawsuits related the economic plans, and ITAÚ UNIBANCO HOLDING has already accepted its terms. Said agreement was approved on March 1, 2018, by the Plenary Session of the Federal Supreme Court (STF) and savers could adhere to its terms for a 24-month period. Due to the end of this term, the parties signed an amendment to the instrument of agreement to extend this period in order to contemplate a higher number of holders of savings accounts and, consequently, to increase the end of lawsuits. In May, 2020 the Federal Supreme Court (STF) approved this amendment and granted a 30-month term for new adhesions, and this term may be extended for another 30 months, subject to the reporting of the number of adhesions over the first period. II- Labor claims Provisions for contingencies arise from lawsuits in which labor rights provided for in labor legislation specific to the related profession are discussed, such as: overtime, salary equalization, reinstatement, transfer allowance and, pension plan supplement. These lawsuits are classified as follows: Collective lawsuits: related to claims considered similar and with individual amounts that are not considered significant. The expected amount of loss is determined and accrued on a monthly basis in accordance with a statistical model which calculates the amount of the claims, and is reassessed taking into account court rulings. Provisions for contingencies are adjusted to reflect the amounts deposited into court as security for execution. Individual lawsuits: related to claims with unusual characteristics or involving significant amounts. These are periodically calculated based on the amounts claimed. The probability of loss is estimated in accordance with the actual and legal characteristics of each lawsuit. III- Other Risks These are quantified and accrued on the basis of the value of rural credit transactions with joint liability and FCVS (salary variations compensation fund) credits assigned to Banco Nacional. Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 110

Below are the changes in civil, labor and other risks provisions: 12/31/2020 Other Civil Labor Total Risks Opening balance—01/01 3,634 8,579 976 13,189 (-) Provisions guaranteed by indemnity clause (Note 2.4.n) (216) (980)—(1,196) Subtotal 3,418 7,599 976 11,993 Adjustment / Interest (Note 23) 191 482—673 Changes in the period reflected in income (Note 23) 889 2,110 547 3,546 Increase 1,179 2,296 550 4,025 Reversal (290) (186) (3) (479) Payment (1,203) (3,126) (40) (4,369) Subtotal 3,295 7,065 1,483 11,843 (+) Provisions guaranteed by indemnity clause (Note 2.4.n) 216 950—1,166 Closing balance 3,511 8,015 1,483 13,009 Current 1,254 3,125 1,483 5,862 Non-current 2,257 4,890—7,147 12/31/2019 Other Civil Labor Total Risks Opening balance—01/01 4,426 6,821 573 11,820 (-) Provisions guaranteed by indemnity clause (Note 2.4.n) (226) (957)—(1,183) Subtotal 4,200 5,864 573 10,637 Adjustment / Interest (Note 23) 122 1,024—1,146 Changes in the period reflected in income (Note 23) 726 3,160 403 4,289 Increase (*) 1,177 3,325 435 4,937 Reversal (451) (165) (32) (648) Payment (1,630) (2,449)—(4,079) Subtotal 3,418 7,599 976 11,993 (+) Provisions guaranteed by indemnity clause (Note 2.4.n) 216 980—1,196 Closing balance 3,634 8,579 976 13,189 Current 1,662 2,451 976 5,089 Non-current 1,972 6,128—8,100 (*) Includes the effects of the Voluntary Severance Program. IV- Tax proceedings and legal obligations Tax provisions correspond to the principal amount of taxes involved in administrative or judicial tax lawsuits, subject to tax assessment notices, plus interest and, when applicable, fines and charges. The table below shows the changes in the provisions: 12/31/2020 12/31/2019 Opening balance—01/01 8,266 6,793 (-) Provisions guaranteed by indemnity clause (Note 2.4 n) (68) (68) Subtotal 8,198 6,725 Adjustment / Interest (*) 220 779 Changes in the period reflected in income 56 843 Increase (*) 142 1,135 Reversal (*) (86) (292) Payment (1,735) (151) Subtotal 6,739 8,196 (+) Provisions guaranteed by indemnity clause (Note 2.4 n) 71 70 Closing balance 6,810 8,266 Current 65 83 Non-current 6,745 8,183 (*) The amounts are included in the headings Tax Expenses, General and Administrative Expenses and Current Income Tax and Social Contribution. Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 111

The main discussions related to Tax Lawsuits and Legal Obligations are described below: · INSS – Non-compensatory Amounts – R$ 1,769: the non-levy of social security contribution on amounts paid as profit sharing is defended. The balance of the deposits in guarantee is R$ 991; · PIS and COFINS – Calculation Basis – R$ 643: defending the levy of PIS and COFINS on revenue, a tax on revenue from the sales of assets and services. The balance of the deposits in guarantee is R$ 618. c) Contingencies not provided for in the Balance Sheet Amounts involved in administrative and judicial arguments with the risk of loss estimated as possible are not provided for and they are basically composed of: I- Civil and Labor Claims In Civil Lawsuits with possible loss, total estimated risk is R$ 4,470 (R$ 4,266 at 12/31/2019), and in this total there are no amounts arising from interests in Joint Ventures. For Labor Claims with possible loss, estimated risk is R$ 389 (R$ 251 at 12/31/2019). II—Tax proceedings The tax proceedings of possible loss totaled R$ 31,330 (R$ 28,959 at 12/31/2019), and the main cases are described below: · INSS – Non-compensatory Amounts – R$ 6,303: defends the non-levy of this contribution on these amounts, among which are profit sharing and stock options; · IRPJ, CSLL, PIS and COFINS – Funding Expenses – R$ 4,857: the deductibility of raising costs (Interbank deposits rates) for funds that were capitalized between Group companies; · ISS – Banking Activities – R$ 3,991: the levy and/or payment place of ISS for certain banking revenues are discussed; · IRPJ and CSLL – Goodwill – Deduction – R$ 3,398: the deductibility of goodwill for future expected profitability on the acquisition of investments; · IRPJ, CSLL, PIS and COFINS – Requests for Offsetting Dismissed—R$ 1,642: cases in which the liquidity and the certainty of credits offset are discussed; · PIS and COFINS—Reversal of Revenues from Depreciation in Excess – R$ 1,346: discussing the accounting and tax treatment of PIS and COFINS upon settlement of leasing operations; · IRPJ and CSLL – Disallowance of Losses – R$ 1,188: discussion on the amount of tax loss (IRPJ) and/or social contribution (CSLL) tax loss carryforwards used by the Federal Revenue Service when drawing up tax assessment notes that are still pending a final decision; · IRPJ and CSLL – Deductibility of Losses with Derivatives – R$ 656: the deductibility of losses calculated in the disposal of financial derivative contracts is being discussed. Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 112

d) Accounts Receivables – Reimbursement of Provisions The receivables balance arising from reimbursements of contingencies totals R$ 919 (R$ 978 at 12/31/2019) (Note 18a), arising basically from the collateral established in Banco Banerj S.A. privatization process occurred in 1997, when the State of Rio de Janeiro created a fund to guarantee the equity recomposition in provisions for Civil, Labor and Tax Claims. e) Guarantees of contingencies, provisions and legal obligations The guarantees related to legal proceedings involving ITAÚ UNIBANCO HOLDING and basically consist of: 12/31/2020 12/31/2019 Civil Labor Tax Total Total Deposits in guarantee (Note 18a) 1,476 2,126 9,091 12,693 14,520 Investment fund quotas 600 303 84 987 1,148 Surety 65 69 3,878 4,012 3,223 Insurance bond 1,837 1,203 15,362 18,402 14,867 Guarantee by government securities 14—235 249 96 Total 3,992 3,701 28,650 36,343 33,854 ITAÚ UNIBANCO HOLDING’s provisions for judicial and administrative challenges are long-term, considering the time required for their questioning, and this prevents the disclosure of a deadline for their conclusion. The legal advisors believe that ITAÚ UNIBANCO HOLDING is not a party to this or any other administrative proceedings or lawsuits that could significantly affect the results of its operations. Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 113

Note 30 – Segment Information The current operational and reporting segments of ITAÚ UNIBANCO HOLDING are described below: · Retail Banking The segment comprises retail customers, account holders and non-account holders, individuals and legal entities, high income clients (Itaú Uniclass and Personnalité) and the companies segment (microenterprises and small companies). It includes financing and credit offers made outside the branch network, in addition to credit cards and payroll loans. · Wholesale Banking It comprises products and services offered to middle-market companies, high net worth clients (Private Banking), and the operation of Latin American units and Itaú BBA, which is the unit responsible for business with large companies and Investment Banking operations. · Activities with the Market + Corporation Basically, corresponds to the result arising from capital surplus, subordinated debt surplus and the net balance of tax credits and debits. It also includes the financial margin on market trading, Treasury operating costs, and equity in earnings of companies not included in either of the other segments. a) Basis of Presentation Segment information is based on the reports used by senior management to assess performance and to make decisions about allocation of funds for investment and other purposes. These reports use a variety of information for management purposes, including financial and non-financial information supported by bases different from information prepared according to accounting practices adopted in Brazil. The main indicators used for monitoring business performance are Recurring Income, and Return on Economic Capital allocated to each business segment. Information by segment has been prepared in accordance with accounting practices adopted in Brazil and is adjusted by the items below: Allocated capital: The statements for each segment consider capital allocation based on a proprietary model and consequent impacts on results arising from this allocation. This model includes the following components: Credit risk, operating risk, market risk and insurance underwriting risk. Income tax rate: We take the total income tax rate, net of the tax effect from the payment of interest on capital, for the Retail Banking, Wholesale Banking and Activities with the Market + Corporation. The difference between the income tax amount calculated by segment and the effective income tax amount, as stated in the consolidated financial statements, is allocated to the Trading + Institutional column. · Reclassification and application of managerial criteria The managerial statement of income was used to prepare information per segment. These statements were obtained based on the statement of income adjusted by the impact of non-recurring events and the managerial reclassifications in income. The main reclassifications between the accounting and managerial results are: Operating revenues: Considers the opportunity cost for each operation. The financial statements were adjusted so that the stockholders’ equity was replaced by funding at market price. Subsequently, the financial statements were adjusted to include revenues related to capital allocated to each segment. The cost of subordinated debt and the respective remuneration at market price were proportionally allocated to the segments, based on the economic capital allocated. Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 114

Tax effects of hedging: The tax effects of hedging of investments abroad were adjusted – they were originally recorded as tax expenses (PIS and COFINS) and Income Tax and Social Contribution on Net Income – and are now reclassified to financial margin. Insurance: The main reclassifications of revenues refer to the financial margins obtained from technical provisions for insurance, pension plans and premium bonds, in addition to revenue from management of pension plan funds. Other reclassifications: Other Income, Share of Income of Associates and joint ventures, Non-Operating Income, Profit Sharing of Management Members and Expenses for Credit Card Reward Program were reclassified to those lines representing the way the ITAÚ UNIBANCO HOLDING manages its business, to provide a clearer understanding of our performance. The adjustments and reclassifications column shows the effects of the differences between the accounting principles followed for the presentation of segment information, which are substantially in line with the accounting practices adopted for financial institutions in Brazil, except as described above, and the policies used in the preparation of these consolidated financial statements according to IFRS. Significant adjustments are as follows: · Requirements for impairment testing of financial assets are based on the expected credit losses model; · Adjustment to fair value due to reclassifications of financial assets to categories of measurement at amortized cost, at fair value through profit and loss or at fair value through other comprehensive income, as a result of the concept of business models of IFRS 9; · Financial assets modified and not written-off, with their balances recalculated in accordance with the requirements of IFRS 9; · Effective interest rate of financial assets and liabilities measured at amortized cost, appropriating revenues and costs directly attributable to their acquisition, issue or disposal over the transaction term, whereas in the standards adopted in Brazil, recognition of expenses and revenues from fees occurs at the time these transactions are contracted; · Goodwill generated in a business combination is not amortized, whereas in the standards adopted in Brazil, it is amortized. Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 115

b) Consolidated Statement of Managerial Result 01/01 to 12/31/2020 Activities with the Retail Wholesale ITAÚ (3) Market + Adjustments IFRS consolidated Banking Banking UNIBANCO Corporation Operating revenues 72,680 32,187 9,918 114,785 (14,586) 100,199 Interest margin (1) 41,818 19,883 8,394 70,095 (20,042) 50,053 Revenues from banking services and bank charges 23,918 11,911 1,401 37,230 1,327 38,557 Income from insurance and private pension operations before claim and selling expenses 6,944 393 123 7,460 (2,972) 4,488 Other revenues — — 7,101 7,101 Cost of Credit (21,247) (8,968) 6 (30,209) 5,583 (24,626) Claims (1,345) (8)—(1,353) (1) (1,354) Operating margin 50,088 23,211 9,924 83,223 (9,004) 74,219 Other operating income / (expenses) (40,221) (16,133) (650) (57,004) (11,985) (68,989) Non-interest expenses (2) (35,310) (14,592) (287) (50,189) (14,018) (64,207) Tax expenses for ISS, PIS and COFINS and Other (4,911) (1,541) (363) (6,815) 634 (6,181) Share of profit or (loss) in associates and joint ventures — — 1,399 1,399 Income before income tax and social contribution 9,867 7,078 9,274 26,219 (20,989) 5,230 Income tax and social contribution (3,071) (1,893) (3,099) (8,063) 17,897 9,834 Non-controlling interest in subsidiaries (175) 601 (46) 380 3,452 3,832 Net income 6,621 5,786 6,129 18,536 360 18,896 Total assets (*)—12/31/2020 1,265,620 981,034 143,715 2,112,586 (93,335) 2,019,251 Total liabilities—12/31/2020 1,218,977 915,253 108,432 1,964,880 (100,154) 1,864,726 (*) Includes: Investments in associates and joint ventures 2,012—13,879 15,891 (321) 15,570 Fixed assets, net 4,587 806—5,393 1,544 6,937 Goodwill and Intangible assets, net 4,978 9,901—14,879 2,451 17,330 (1) Includes interest and similar income, expenses and dividend of R$ 55,420, net gains (loss) on investment securities and derivatives of R$ (8,056) and results from foreign exchange operations and exchange variation of transactions abroad of R$ 2,689. (2) Refers to general and administrative expenses including depreciation and amortization expenses of R$ (5,064). (3) The IFRS Consolidated figures do not represent the sum of the parties because there are intercompany transactions that were eliminated only in the consolidated statements. Segments are assessed by top management, net of income and expenses between related parties. Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 116

01/01 to 12/31/2019 Activities with the Retail Wholesale ITAÚ IFRS Market + Adjustments (3) Banking Banking UNIBANCO consolidated Corporation Operating revenues 79,227 30,650 9,913 119,790 (2,711) 117,079 Interest margin (1) 46,764 18,778 9,088 74,630 (5,280) 69,350 Commissions and Banking Fees 25,411 11,306 590 37,307 1,725 39,032 Income from insurance and private pension operations before claim and selling expenses 7,052 566 235 7,853 (3,300) 4,553 Other revenues — — 4,144 4,144 Cost of Credit (16,072) (2,082)—(18,154) 882 (17,272) Claims (1,206) (59)—(1,265) (30) (1,295) Operating margin 61,949 28,509 9,913 100,371 (1,859) 98,512 Other operating income / (expenses) (41,430) (15,403) (986) (57,819) (9,450) (67,269) Non-interest expenses (2) (36,346) (13,940) (365) (50,651) (10,361) (61,012) Tax expenses for ISS, PIS and COFINS and Other (5,084) (1,463) (621) (7,168) (404) (7,572) Share of profit or (loss) in associates and joint ventures — — 1,315 1,315 Income before income tax and social contribution 20,519 13,106 8,927 42,552 (11,309) 31,243 Income tax and social contribution (7,095) (3,856) (2,545) (13,496) 10,066 (3,430) Non-controlling interest in subsidiaries (198) (444) (51) (693) (7) (700) Net income 13,226 8,806 6,331 28,363 (1,250) 27,113 Total assets (*)—12/31/2019 1,056,275 682,271 147,901 1,738,713 (101,232) 1,637,481 Total liabilities—12/31/2019 1,013,186 625,614 104,799 1,595,865 (107,849) 1,488,016 (*) Includes: Investments in associates and joint ventures 1,911—13,666 15,577 (480) 15,097 Fixed assets, net 5,252 1,160—6,412 754 7,166 Goodwill and Intangible assets, net 6,681 7,645—14,326 5,393 19,719 (1) Includes interest and similar income,expenses and dividend of R$ 64,325, net gains (loss) on investment securities and derivatives of R$ 4,098 and results from foreign exchange operations and exchange variation of transactions abroad of R$ 927. (2) Refers to general and administrative expenses including depreciation and amortization expenses of R$ (4,630). (3) The IFRS Consolidated figures do not represent the sum of the segments because there are intercompany transactions that were eliminated only in the consolidated financial statements. Segments are assessed by top management, net of income and expenses between related parties. Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 117

01/01 to 12/31/2018 Activities with Retail Wholesale ITAÚ IFRS the Market + Adjustments (3) Banking Banking UNIBANCO consolidated Corporation Operating revenues 72,182 29,389 10,246 111,817 (7,617) 104,200 Interest margin (1) 40,243 18,930 9,912 69,085 (8,380) 60,705 Commissions and Banking Fees 25,131 9,810 138 35,079 1,730 36,809 Income from insurance and private pension operations before claim and selling expenses 6,808 649 196 7,653 (3,692) 3,961 Other revenues — — 2,725 2,725 Cost of Credit (12,526) (1,540)—(14,066) 5,112 (8,954) Claims (1,160) (68)—(1,228)—(1,228) Operating margin 58,496 27,781 10,246 96,523 (2,505) 94,018 Other operating income / (expenses) (40,002) (15,217) (1,070) (56,289) (7,121) (63,410) Non-interest expenses (2) (35,296) (13,817) (331) (49,444) (8,094) (57,538) Tax expenses for ISS, PIS and COFINS and Other (4,706) (1,400) (739) (6,845) 226 (6,619) Share of profit or (loss) in associates and joint ventures — — 747 747 Net income before income tax and social contribution 18,494 12,564 9,176 40,234 (9,626) 30,608 Income tax and social contribution (6,939) (3,829) (2,964) (13,732) 8,763 (4,969) Non-controlling interest in subsidiaries (184) (550) (35) (769) 37 (732) Net income 11,371 8,185 6,177 25,733 (826) 24,907 Total assets (*)—12/31/2018 1,042,145 655,393 142,853 1,649,613 (96,816) 1,552,797 Total liabilities—12/31/2018 1,005,194 597,528 93,546 1,505,490 (103,159) 1,402,331 (*) Includes: Investments in associates and joint ventures 1,220—11,438 12,658 (639) 12,019 Fixed assets, net 5,526 879—6,405 897 7,302 Goodwill and Intangible assets, net 6,845 8,178—15,023 4,306 19,329 (1) Includes net interest and similar income and expenses of R$ 62,565, net gain (loss) on investment securities and derivatives of R$ (4,834) and foreign exchange results and exchange variation on transactions of abroad R$ 2,974. (2) Refers to general and administrative expenses including depreciation and amortization expenses of R$ (3,332). (3) The IFRS Consolidated figures do not represent the sum of the segments because there are intercompany transactions that were eliminated only in the consolidated financial statements. Segments are assessed by top management, net of income and expenses between related parties. Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 118

c) Result of Non-Current Assets and Main Services and Products by Geographic Region 12/31/2020 12/31/2019 Brazil Abroad Total Brazil Abroad Total Non-current assets 17,095 7,172 24,267 16,123 10,762 26,885 01/01 to 12/31/2020 01/01 to 12/31/2019 01/01 to 12/31/2018 Brazil Abroad Total Brazil Abroad Total Brazil Abroad Total Income related to financial operations (1) (2) 102,016 21,595 123,611 117,541 27,767 145,308 108,362 22,955 131,317 Income from insurance and private pension operations before claim and selling expenses 4,488—4,488 4,423 130 4,553 3,812 149 3,961 Commissions and Banking Fees 34,533 4,024 38,557 35,283 3,749 39,032 33,211 3,598 36,809 (1) Includes interest and similar income, dividend income, net gain (loss) on investment securities and derivatives, foreign exchange results, and exchange variation on transactions abroad. (2) ITAÚ UNIBANCO HOLDING does not have customers representing 10% or higher of its revenues. Note 31 – Related parties Transactions between related parties are carried out for amounts, terms and average rates in accordance with normal market practices during the period, and under reciprocal conditions. Transactions between companies and investment funds, included in consolidation (note 2.4a), have been eliminated and do not affect the consolidated statements. The principal unconsolidated related parties are as follows: · Itaú Unibanco Participações S.A. (IUPAR), Companhia E. Johnston de Participações S.A. (shareholder of IUPAR) and ITAÚSA, direct and indirect shareholders of ITAÚ UNIBANCO HOLDING; · The associates, non-financial subsidiaries and joint ventures of ITAÚSA, in particular Duratex S.A., Copagaz – Distribuidora de Gás S.A. and Alpargatas S.A.; · Investments in associates and joint ventures, in particular Porto Seguro Itaú Unibanco Participações S.A., BSF Holding S.A. and XP Inc.; · Pension Plans: Fundação Itaú Unibanco – Previdência Complementar and FUNBEP – Fundo de Pensão Multipatrocinado, closed-end supplementary pension entities, that administer retirement plans sponsored by ITAÚ UNIBANCO HOLDING, created exclusively for employees; · Associations: Associação Cubo Coworking Itaú – a partner entity of ITAÚ UNIBANCO HOLDING its purpose is to encourage and promote the discussion and development of alternative and innovative technologies, business models and solutions; the produce and disseminate the resulting technical and scientific knowledge; the attract and bring in new information technology talents that may be characterized as startups; and to research, develop and establish ecosystems for entrepreneur and startups; · Foundations and Institutes maintained by donations from ITAÚ UNIBANCO HOLDING and by the proceeds generated by their assets, so that they can accomplish their objectives and to maintain their operational and administrative structure: Fundação Itaú para a Educação e Cultura – promotes education, culture, social assistance, defense and guarantee of rights, and strengthening of civil society. Instituto Unibanco – supports projects focused on social assistance, particularly education, culture, promotion of integration into the labor market, and environmental protection, directly or as a supplement to civil institutions. Instituto Unibanco de Cinema – promotes culture in general and provides access of low-income families to screenings of films, videos, video-laser discs etc, in theaters and movie clubs which it owns or manages including showings of popular movies, in particular Brazilian productions. Associação Itaú Viver Mais – provides social services for the welfare of beneficiaries, on the terms defined in its Internal Regulations, and according to the funds available. These services may include the promotion of cultural, educational, sports, entertainment and healthcare activities. Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 119

a) Transactions with related parties: ITAÚ UNIBANCO HOLDING Assets / (Liabilities) Revenues / (Expenses) Annual rate 12/31/2020 12/31/2019 01/01 to 01/01 to 01/01 to 12/31/2020 12/31/2019 12/31/2018 Short-term Interbank investments 18,539 1,000 63 58—Other 1.90% 18,539 1,000 63 58—Loan operations 591 83 56 6 187 2.50% to 6% / SELIC + 2.35 / CDI Alpargatas S.A. 65 30 36 1 3 + 3.85% to 3.95% Duratex S.A. CDI + 1.45% 515—19 —Other 113% CDI 11 53 1 5 184 Securities and derivative financial instruments (assets and liabilities) 1,716 99 6—(138) Investment funds 107 99 14 —Copagaz – Distribuidora de Gás S.A. CDI + 1.70% 950—1—-Itaúsa S.A. CDI + 2.40% 771—1—(138) Other (112)—(10) — Deposits — (1) (1) (10) Other — (1) (1) (10) Deposits received under securities repurchase agreements (165) (374) (13) (14) (2) Alpargatas S.A. 95% to 101% CDI (107) (4) (11) —Duratex S.A. 78% to 99% CDI (49) (43) (2) (2) (1) Other 100% CDI (9) (327)—(12) (1) Amounts receivable (payable) / Commissions and/or Other General and (35) (151) 26 3 50 Administrative expenses Instituto Unibanco 123—3—2 Fundação Itaú Unibanco – Previdência Complementar (93) (93) 42 43 51 ConectCar Soluções de Mobilidade Eletrônica S.A. (46) (46) 7 7 4 Olímpia Promoção e Serviços S.A. (9) (5) (45) (31) (25) Itaúsa S.A. (8) 1 12 (28) 6 Fundação Itaú para a Educação e Cultura (4)—(3) 1 1 FUNBEP—Fundo de Pensão Multipatrocinado (1)—7 7 6 Other 3 (8) 3 4 5 Rent — (31) (39) (46) Fundação Itaú Unibanco – Previdência Complementar — (28) (32) (36) FUNBEP – Fundo de Pensão Multipatrocinado — (3) (6) (7) Other ——(1) (3) Donation (500)—(1,002) (35) (95) Fundação Itaú para a Educação e Cultura (500)—(1,000) (35) (95) Other — (2) — Sponsorship 12 29 (16) (15) (32) Associação Cubo Coworking Itaú 12 29 (16) (14) (31) Other ——(1) (1) Operations with Key Management Personnel of ITAÚ UNIBANCO HOLDING present Assets of R$ 65, Liabilities of R$ (6,623) and Results of R$ (58) (R$ 49, R$ (5,758) at 12/31/2019 and R$ (28) from 01/01 to 12/31/2019, respectively). b) Compensation and Benefits of Key Management Personnel Compensation and benefits attributed to Managers Members, members of the Audit Committee and the Board of Directors of ITAÚ UNIBANCO HOLDING in the period correspond to: 01/01 to 01/01 to 01/01 to 12/31/2020 12/31/2019 12/31/2018 Fees (578) (499) (481) Profit sharing (112) (363) (258) Post-employment benefits (9) (6) (9) Share-based payment plan (228) (224) (212) Total (927) (1,092) (960) Total amounts related to share-based payment plans, personnel expenses and post-employment benefits is detailed in Notes 20, 23 and 26, respectively. Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 120

Note 32 – Risk and Capital Management a) Corporate Governance ITAÚ UNIBANCO HOLDING invests in robust risk management processes and capital management that are the basis for its strategic decisions to ensure business sustainability and maximize shareholder value creation. These processes are aligned with the guidelines of the Board of Directors and Executive which, through collegiate bodies, define the global objectives expressed as targets and limits for the business units that manage risk. Control and capital management units, in turn, support ITAÚ UNIBANCO HOLDING’s management by monitoring and analyzing risk and capital. The Board of Directors is the main body responsible for establishing guidelines, policies and approval levels for risk and capital management. The Capital and Risk Management Committee (CGRC), in turn, is responsible for supporting the Board of Directors in managing capital and risk. At the executive level, collegiate bodies, presided over by the Chief Executive Officer (CEO) of ITAÚ UNIBANCO HOLDING, are responsible for capital and risk management, and their decisions are monitored by the CGRC. Additionally, ITAÚ UNIBANCO HOLDING has collegiate bodies with capital and risk management responsibilities delegated to them, chaired by the Executive Vice-President of the Risk and Finance Department (ARF). To support this structure, ARF has departments to ensure, on an independent and centralized basis, that the institution’s risks and capital are managed in compliance with defined policies and procedures. b) Risk Management Risk Appetite The risk appetite of ITAÚ UNIBANCO HOLDING is based on the Board of Director’s statement: “We are a universal bank, operating mainly in Latin America. Supported by our risk culture, we insist on with strict ethical standards and regulatory compliance, seeking high and increasing returns, with low volatility, through lasting relationships with our customers, accurate risk pricing, widespread funding and proper use of capital.” Based on this statement, five dimensions have been defined, each dimension consists of a set of metrics associated with the main risks involved, combining supplementary measurement methods, to give a comprehensive vision of our exposure. The Board of Directors is responsible for approving guidelines and limits for risk appetite, with the support of CGRC and the CRO (Chief Risk Officer). The limits for risk appetite are monitored regularly and reported to risk committees and to the Board of Directors, which will oversee the preventive measures to be taken to ensure that exposure is aligned with the strategies of ITAÚ UNIBANCO HOLDING. The five dimensions of risk appetite are: · Capitalization: establishes that ITAÚ UNIBANCO HOLDING must have capital sufficient to face any serious recession period or a stress event without the need to adjust its capital structure under unfavorable circumstances. It is monitored by tracking ITAÚ UNIBANCO HOLDING’s capital ratios, both in normal and stress scenarios, and of the ratings of the institution’s debt issues. · Liquidity: establishes that the liquidity of ITAÚ UNIBANCO HOLDING must withstand long periods of stress. It is monitored tracking liquidity indicators. · Composition of results: defines that business will be focused primarily on Latin America, where ITAÚ UNIBANCO HOLDING has a diversified base of customers and products, with low appetite for income volatility or for high risk. This dimension comprises aspects related to business, profitability, market risk and credit risk. By adopting exposure concentration limits, such as industry sectors, counterparty quality, countries and geographical regions and risk factors, these monitored metrics are intended to ensure well-adjusted portfolios, low income volatility and business sustainability. Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 121

· Operational risk: focuses on the control of operating risk events that may adversely impact business and operating strategy, and involves monitoring the main operational risk events and losses incurred. · Reputation: addresses risks that may impact the institution’s brand value and reputation with customers, employees, regulatory bodies, investors and the general public. The risk monitoring in this dimension is carried out by tracking customer satisfaction or dissatisfaction and media exposure, in addition to monitoring the institution’s conduct. Risk appetite, risk management and guidelines for employees of ITAÚ UNIBANCO HOLDING for routine decision-making purposes are based on: · Sustainability and customer satisfaction: ITAÚ UNIBANCO HOLDING vision is to be the leading bank in sustainable performance and customer satisfaction and, accordingly, we are committed to creating shared value for staff, customers, stockholders and society, ensuring the continuity of the business. ITAÚ UNIBANCO HOLDING is committed to doing business that is good both for the customer and the institution itself; · Risk culture: ITAÚ UNIBANCO HOLDING’s risk culture goes beyond policies, procedures or processes, reinforcing the individual and collective responsibility of all employees so that they will do the right thing at the right time and in the proper manner, respecting the ethical way of doing business; · Risk pricing: ITAÚ UNIBANCO HOLDING’s operates and assumes risks in business that it knows and understands, avoids the ones that are unknown or that do not provide competitive advantages, and carefully assesses risk-return ratios; · Diversification: ITAÚ UNIBANCO HOLDING has little appetite for volatility in earnings, and it therefore operates with a diverse base of customers, products and business, seeking to diversify risks and giving priority to lower risk business; · Operational excellence: It is the wish of ITAÚ UNIBANCO HOLDING to be an agile bank, with a robust and stable infrastructure enabling us to offer top quality services; · Ethics and respect for regulations: for ITAÚ UNIBANCO HOLDING, ethics is non-negotiable, and it therefore promotes an institutional environment of integrity, encouraging staff to cultivate ethics in relationships and business and to respect the rules, thus caring for the institution’s reputation. ITAÚ UNIBANCO HOLDING has various ways of disseminating risk culture, based on four principles: conscious risk-taking, discussion of the risks the institution faces, the corresponding action taken, and the responsibility of everyone for managing risk. These principles serve as a basis for ITAÚ UNIBANCO HOLDING guidelines, helping employees to conscientiously understand, identify, measure, manage and mitigate risks. 1. Credit risk The possibility of losses arising from failure by a borrower, issuer or counterparty to meet their financial obligations, the impairment of a loan due to downgrading of the risk rating of the borrower, the issuer or the counterparty, a decrease in earnings or remuneration, advantages conceded on renegotiation or the costs of recovery. There is a credit risk control and management structure, centralized and independent from the business units, that provides for operating limits and risk mitigation mechanisms, and also establishes processes and tools to measure, monitor and control the credit risk inherent in all products, portfolio concentrations and impacts of potential changes in the economic environment. The credit policy of ITAÚ UNIBANCO HOLDING is based on internal criteria such as: classification of customers, portfolio performance and changes, default levels, rate of return and economic capital allocated, and external factors such as interest rates, market default indicators, inflation, changes in consumption, and so on. Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 122

For personal customers and small and middle-market companies, credit rating is based on statistical application models (at the early stages of the relationship with a customer) and behavior score (used for customers with which ITAÚ UNIBANCO HOLDING already has a relationship). For large companies, the rating is based on information such as economic and financial condition of the counterparty, their cash-generating capability, the economic group to which they belong, and the current and prospective situation of the economic sector in which they operate. Credit proposals are analyzed on a case by case basis, through an approval-level mechanism. ITAÚ UNIBANCO HOLDING strictly controls the credit exposure of customers and counterparties, taking action to address situations in which the current exposure exceeds what is desirable. For this purpose, measures provided for in loan agreements are available, such as accelerated maturity or a requirement for additional collateral. 1.1 Collateral and policies for mitigating credit risk ITAÚ UNIBANCO HOLDING uses guarantees to increase its capacity for recovery in operations exposed to credit risk. The guarantees may be personal, secured, legal structures with mitigating power and offset agreements. For collateral to be considered instruments that mitigate credit risk, they must comply with the requirements and standards that regulate them, both internal and external ones, and they must be legally valid (effective), enforceable, and assessed on a regular basis. ITAÚ UNIBANCO HOLDING also uses credit derivatives, to mitigate credit risk of its portfolios of loans and securities. These instruments are priced based on models that use the fair value of market inputs, such as credit spreads, recovery rates, correlations and interest rates. 1.2 Policy for Provisioning and Economic Scenarios Both the credit risk and the finance areas are responsible for defining the methods used to measure expected loan losses and for periodically assessing changes in the provision amounts. These areas monitor the trends observed in provisions for expected credit losses by segment, in addition to establishing an initial understanding of the variables that may trigger changes in the allowance for loan losses, the probability of default (PD) or the loss given default (LGD). Once the trends have been identified and an initial assessment of the variables has been made at the corporate level, the business areas are responsible for further analyzing these trends in more detail and for each segment, in order to understand the underlying reasons for the trends and to decide whether changes are required in credit policies. Provisions for expected losses take into account the expected risk linked to contracts with similar characteristics and in anticipation of signs of deterioration, over a loss horizon suitable for the remaining period of the contract to maturity. For contracts of products with no determined termination date, average results of deterioration and default are used to determine the loss horizon. Additionally, information on economic scenarios and public data with internal projections are used to determine and adjust the expected credit loss in line with expected macroeconomic realities. Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 123

Sensitivity analysis ITAÚ UNIBANCO HOLDING prepares studies on the impact of estimates in the calculation of expected credit loss. The expected loss models use three different scenarios: Optimistic, Base and Pessimistic.In Brazil, where operations are substantially carried out, these scenarios are combined by weighting their probabilities: 15%, 40% and 45% (2019 – 10%, 75% and 15%), respectively, which are updated so as to reflect the new economic conditions. For loan portfolios originated in other countries, the scenarios are weighted by different probabilities, considering regional economic aspects and conditions The table below shows the amount of financial assets at amortized cost and at fair value through other comprehensive income, expected loss and the impacts on the calculation of expected credit loss in the adoption of 100% of each scenario: 12/31/2020 12/31/2019 Reduction/(Increase) of Reduction/(Increase) of Financial Expected Expected Loss Financial Expected Expected Loss Assets (1) Loss (2) Assets (1) Loss (2) Pessimistic Base Optimistic Pessimistic Base Optimistic scenario scenario scenario scenario scenario scenario 951,343 (51,480) (830) 491 1,416 793,610 (40,247) (328) 13 193 (1) Composed of Loan operations, lease operations and securities. (2) Comprises expected credit loss for Financial Guarantees R$ (907) (R$ (837) at 12/31/2019) and Loan Commitments R$ (3,485) (R$ (3,303) at 12/31/2019). 1.3 Classification of Stages of Credit Impairment ITAÚ UNIBANCO HOLDING uses customers’ internal information, statistic models, days of default and quantitative analysis in order to determine the credit status of portfolio agreements. Rules for changing stages take into account lower and higher internal limits (quantitative criteria), in addition to the relative variation in the rating since the initial recognition. Information on days of delay, used on an absolute basis, is an important factor for the classification of stages, and after a certain credit status has been defined for an agreement, it is classified in one of the three stages of credit deterioration. Based on this classification, rules for measuring expected credit loss in each stage are used, as described in Note 2.4d. For retail and middle market portfolios, ITAÚ UNIBANCO HOLDING classifies loan agreements which are over 30 days overdue in stage 2, except payroll loans for government agency, for which the figure is 45 days, due to the dynamics of payment for transfer of the product. For the Wholesale business portfolio, information on arrears is taken into account when allocating a rating. Default parameters are: 90 days with no payments made(*); debt restructuring; adjudication of bankruptcy; loss; and court-ordered restructuring. (*) For the real estate loans portfolio, the figure is 180 days with no payments made. Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 124

1.4 Maximum Exposure of Financial Assets to Credit Risk 12/31/2020 12/31/2019 Brazil Abroad Total Brazil Abroad Total Financial Assets 1,294,428 466,835 1,761,263 1,073,430 336,803 1,410,233 At Amortized Cost 861,485 324,255 1,185,740 755,773 254,871 1,010,644 Interbank deposits 17,775 37,910 55,685 10,620 23,963 34,583 Securities purchased under agreements to resell 237,528 2,415 239,943 197,157 1,271 198,428 Securities 103,146 26,658 129,804 114,046 19,073 133,119 Loan and lease operations 468,461 245,643 714,104 386,206 199,585 585,791 Other financial assets 67,425 25,830 93,255 75,968 18,784 94,752 (-) Provision for Expected Loss (32,850) (14,201) (47,051) (28,224) (7,805) (36,029) At Fair Value Through Other Comprehensive Income 48,992 60,950 109,942 35,990 40,670 76,660 Securities 48,992 60,950 109,942 35,990 40,670 76,660 At Fair Value Through Profit or Loss 383,951 81,630 465,581 281,667 41,262 322,929 Securities 365,718 23,353 389,071 271,470 9,605 281,075 Derivatives 18,227 58,277 76,504 10,197 31,657 41,854 Other financial assets 6—6 ——Financial liabilities—provision for expected loss 3,655 737 4,392 3,581 559 4,140 Loan Commitments 3,135 350 3,485 2,909 394 3,303 Financial Guarantees 520 387 907 672 165 837 Off balance sheet 372,542 58,773 431,315 338,262 48,893 387,155 Financial Guarantees 51,830 17,103 68,933 52,663 14,057 66,720 Letters of credit to be released 41,477—41,477 15,013—15,013 Loan commitments 279,235 41,670 320,905 270,586 34,836 305,422 Mortgage loans 6,357—6,357 5,536—5,536 Overdraft accounts 126,302—126,302 124,449—124,449 Credit cards 144,386 3,859 148,245 138,014 2,823 140,837 Other pre-approved limits 2,190 37,811 40,001 2,587 32,013 34,600 Total 1,663,315 524,871 2,188,186 1,408,111 385,137 1,793,248 Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 125

Amounts shown for credit risk exposure are based on gross book value and do not take into account any collateral received or other added credit improvements. The contractual amounts of financial guarantees and letters of credit cards represent the maximum potential of credit risk in the event that a counterparty does not meet the terms of the agreement. The vast majority of loan commitments (mortgage loans, overdraft accounts and other pre-approved limits) mature without being drawn, since they are renewed monthly and can be cancelled unilaterally. As a result, the total contractual amount does not represent our real future exposure to credit risk or the liquidity needs arising from such commitments. 1.4.1. By business sector Loans and lease operations 12/31/2020 % 12/31/2019 % Industry and commerce 163,784 22.9 129,998 22.2 Services 172,322 24.1 126,718 21.6 Other sectors 37,565 5.3 26,693 4.6 Individuals 340,433 47.7 302,382 51.6 Total 714,104 100.0 585,791 100.0 Other financial assets (*) 12/31/2020 % 12/31/2019 % Public sector 713,705 71.2 562,485 73.5 Services 79,788 8.0 59,193 7.7 Other sectors 67,636 6.8 45,744 6.0 Financial 139,820 14.0 98,297 12.8 Total 1,000,949 100.0 765,719 100.0 (*) Includes Financial Assets at Fair Value through Profit and Loss, Financial Assets at Fair Value through Other Comprehensive Income and Financial Assets at Amortized Cost, except for Loan and Lease Operations and Other Financial Assets. The exposure of Off Balance financial instruments (Financial Collaterals and Loan Commitments) is neither categorized nor managed by business sector. Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 126

1.4.2 By type and classification of credit risk Loan and lease operations 12/31/2020 Stage 1 Stage 2 Stage 3 Total Consolidated of 3 stages Loans Loan Financial Loans Loan Financial Loans Loan Financial Loans Loan Financial Total Total Total Total Operations commitments Guarantees Operations commitments Guarantees Operations commitments Guarantees Operations commitments Guarantees Individuals 199,158 190,273 854 390,285 30,793 19,387 - 50,180 25,532 987 - 26,519 255,483 210,647 854 466,984 Corporate 123,665 17,670 43,602 184,937 2,793 16 595 3,404 8,063 93 2,516 10,672 134,521 17,779 46,713 199,013 Micro/Small and medium companies 96,784 50,813 5,434 153,031 15,965 3,884 440 20,289 9,206 307 131 9,644 121,955 55,004 6,005 182,964 Foreign loans—Latin America 167,601 35,960 14,498 218,059 16,692 1,414 676 18,782 17,852 101 187 18,140 202,145 37,475 15,361 254,981 Total 587,208 294,716 64,388 946,312 66,243 24,701 1,711 92,655 60,653 1,488 2,834 64,975 714,104 320,905 68,933 1,103,942 % 62.1 31.1 6.8 100.0 71.5 26.7 1.8 100.0 93.3 2.3 4.4 100.0 64.7 29.1 6.2 100.0 12/31/2019 Stage 1 Stage 2 Stage 3 Total Consolidated of 3 stages Loans Loan Financial Loans Loan Financial Loans Loan Financial Loans Loan Financial Total Total Total Total Operations commitments Guarantees Operations commitments Guarantees Operations commitments Guarantees Operations commitments Guarantees Individuals 199,907 197,717 861 398,485 19,070 6,437 - 25,507 21,513 763 - 22,276 240,490 204,917 861 446,268 Corporate 91,448 16,411 44,720 152,579 911 22 200 1,133 8,430 102 3,420 11,952 100,789 16,535 48,340 165,664 Micro/Small and medium companies 77,722 50,307 4,817 132,846 7,225 2,378 38 9,641 5,786 190 46 6,022 90,733 52,875 4,901 148,509 Foreign loans—Latin America 132,812 29,842 12,087 174,741 14,714 1,166 424 16,304 6,253 87 107 6,447 153,779 31,095 12,618 197,492 Total 501,889 294,277 62,485 858,651 41,920 10,003 662 52,585 41,982 1,142 3,573 46,697 585,791 305,422 66,720 957,933 % 58.5 34.3 7.2 100.0 79.7 19.0 1.3 100.0 89.9 2.4 7.7 100.0 61.1 31.9 7.0 100.0 12/31/2020 12/31/2019 Internal Rating Stage 1 Stage 2 Stage 3 Total loans Stage 1 Stage 2 Stage 3 Total loans Low 501,463 13,172 - 514,635 420,936 4,204 - 425,140 Medium 84,193 37,249 - 121,442 80,106 17,871 - 97,977 High 1,552 15,822 - 17,374 847 19,845 - 20,692 Credit-Impaired — 60,653 60,653 — 41,982 41,982 Total 587,208 66,243 60,653 714,104 501,889 41,920 41,982 585,791 % 82.2 9.3 8.5 100.0 85.6 7.2 7.2 100.0 Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 127

Other financial assets 12/31/2020 Fair Value Stage 1 Stage 2 Stage 3 Cost Fair Value Cost Fair Value Cost Fair Value Investment funds 14,204 3,232 2,997 10,943 10,943 1,232 264 Government securities 483,791 479,477 483,791 — — Brazilian government 422,098 417,782 422,098 — — Other Public - 36 — ——Other countries 61,693 61,659 61,693 — — Argentina 1,498 1,480 1,498 — —United States 5,835 5,847 5,835 — —Mexico 10,222 10,227 10,222 — —Italy 130 133 130 — —Spain 4,844 4,847 4,844 — —Korea 3,947 3,951 3,947 — —Chile 23,195 23,183 23,195 — —Paraguay 2,950 3,011 2,950 — —Uruguay 978 964 978 — —Colombia 8,089 8,012 8,089 — —Peru 5 4 5 — — Corporate securities 127,757 122,695 122,326 3,485 2,738 5,873 2,693 Rural product note 5,823 5,717 5,723 38 36 115 64 Real estate receivables certificates 5,342 5,290 5,268 77 73—1 Bank deposit certificate 1,066 1,064 1,066 — —Debentures 62,723 57,963 58,365 2,402 1,779 5,462 2,579 Eurobonds and other 7,604 7,445 7,604 — —Financial bills 15,783 15,784 15,783 — —Promissory notes 7,629 7,611 7,629 — —Other 21,787 21,821 20,888 968 850 296 49 Total 625,752 605,404 609,114 14,428 13,681 7,105 2,957 Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 128

12/31/2019 Stage 1 Stage 2 Stage 3 Fair Value Cost Fair Value Cost Fair Value Cost Fair Value Investment funds 8,267 8,322 8,062 — 955 205 Government securities 366,998 364,078 366,998 — — Brazilian government 327,681 324,637 327,681 — — Other Public—36 — ——Other countries 39,317 39,405 39,317 — — Argentina 318 349 318 — —United States 2,977 2,979 2,977 — —Mexico 7,820 7,820 7,820 — —Italy 329 328 329 — —Spain 4,984 4,984 4,984 — —Korea 3,427 3,427 3,427 — —Chile 12,317 12,227 12,317 — —Paraguay 1,782 1,959 1,782 — —Uruguay 710 716 710 — —Colombia 4,622 4,585 4,622 — —Peru 8 8 8 — —Germany 23 23 23 — — Corporate securities 112,936 109,169 108,685 637 402 6,784 3,849 Rural product note 5,341 5,122 5,114 62 58 204 169 Real estate receivables certificates 7,312 7,253 7,280 10 11 20 21 Bank deposit certificate 3,217 3,217 3,217 — —Debentures 51,510 47,751 47,607 336 283 6,311 3,620 Eurobonds and other 5,732 5,671 5,704 29 28 —Financial bills 18,514 18,517 18,514 — —Promissory notes 5,311 5,314 5,311 — —Other 15,999 16,324 15,938 200 22 249 39 Total 488,201 481,569 483,745 637 402 7,739 4,054 Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 129

Other Financial Assets—Internal Classification by Level of Risk 12/31/2020 Financial Assets—At Amortized Cost Financial Assets at fair Financial assets at fair value Interbank deposits and value through other through profit or loss (*) Internal rating securities purchased under Securities comprehensive income Total agreements to resell Low 295,334 123,553 463,168 109,942 991,997 Medium—4,396 2,192 - 6,588 High 294 1,855 215 - 2,364 Total 295,628 129,804 465,575 109,942 1,000,949 % 29.5 13.0 46.5 11.0 100.0 (*) Includes Derivatives in the amount of R$ 76,504 at 12/31/2020. 12/31/2019 Financial Assets—At Amortized Cost Financial Assets at fair Financial assets at fair value Interbank deposits and value through other through profit or loss (*) Internal rating securities purchased under Securities comprehensive income Total agreements to resell Low 233,011 127,251 321,595 76,660 758,517 Medium—3,721 952 - 4,673 High—2,147 382 - 2,529 Total 233,011 133,119 322,929 76,660 765,719 % 30.4 17.4 42.2 10.0 100.0 (*) Includes Derivatives in the amount of R$ 41,854 at 12/31/2019. Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 130

1.4.3 Collateral for loans and lease operations 12/31/2020 12/31/2019 Over-collateralized assets Under-collateralized assets Over-collateralized assets Under-collateralized assets Carrying Carrying Carrying Carrying Fair value of Fair value of Fair value of Fair value of value of the value of the value of the value of the collateral collateral collateral collateral assets assets assets assets Individuals 80,907 202,819 1,746 1,621 65,921 170,045 1,997 1,867 Personal (1) 1,960 6,759 737 698 978 2,982 857 819 Vehicles (2) 21,595 44,673 999 918 17,720 37,355 1,102 1,020 Mortgage loans (3) 57,352 151,387 10 5 47,223 129,708 38 28 Micro, small and medium companies and corporates (4) 151,129 444,696 31,582 27,011 115,608 311,043 11,097 6,142 Foreign loans—Latin America (4) 161,987 309,489 15,381 9,050 123,367 222,300 7,348 2,841 Total 394,023 957,004 48,709 37,682 304,896 703,388 20,442 10,850 (1) In general requires financial collaterals. (2) Vehicles themselves are pledged as collateral, as well as assets leased in lease operations. (3) Properties themselves are pledged as collateral. (4) Any collateral set forth in the credit policy of ITAÚ UNIBANCO HOLDING (chattel mortgage, surety/joint debtor, mortgage and others). Of total loans and lease operations R$ 271,372 (R$ 260,453 at 12/31/2019), represented unsecured loans. Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 131

1.4.4 Repossessed assets Assets received from the foreclosure of loans, including real estate, are initially recorded at the lower of: (i) the fair value of the asset less the estimated selling expenses, or (ii) the carrying amount of the loan. Further impairment of assets is recorded as a provision, with a corresponding charge to income. The maintenance costs of these assets are expensed as incurred. The policy for sales of these assets includes periodic auctions that are announced to the market in advance, and provides that the assets cannot be held for more than one year, as stipulated by BACEN. Total repossessed assets in the period were R$ 224 (R$ 390 from 01/01 to 12/31/2019), mainly composed of real estate. 2. Market risk The possibility of incurring financial losses from changes in the market value of positions held by a financial institution, including the risks of transactions subject to fluctuations in currency rates, interest rates, share prices, price indexes and commodity prices, as set forth by CMN. Price Indexes are also treated as a risk factor group. Market risk is controlled by an area independent from the business areas, which is responsible for the daily activities of (i) risk measurement and assessment, (ii) monitoring of stress scenarios, limits and alerts, (iii) application, analysis and testing of stress scenarios, (iv) risk reporting to those responsible within the business areas, in compliance with the governance of ITAÚ UNIBANCO HOLDING, (v) monitoring of actions required to adjust positions and risk levels to make them realistic, and (vi) providing support for the safe launch of new financial products. The market risk structure categorizes transactions as part of either the banking portfolio or the trading portfolio, in accordance with general criteria established by CMN Resolution 4,557, of February 23, 2017, and BACEN Circular 3,354, of June 27, 2007. The trading portfolio consists of all transactions involving financial instruments and commodities, including derivatives, which are held for trading. The banking portfolio is basically characterized by transactions for the banking business, and transactions related to the management of the balance sheet of the institution, where there is no intention of sale and time horizons are medium and long term. Market risk management is based on the following metrics: · Value at risk (VaR): a statistical measure that estimates the expected maximum potential economic loss under normal market conditions, considering a certain time horizon and confidence level; · Losses in stress scenarios (Stress Test): simulation technique to assess the behavior of assets, liabilities and derivatives of a portfolio when several risk factors are taken to extreme market situations (based on prospective and historical scenarios); · Stop loss: metrics used to revise positions, should losses accumulated in a fixed period reach a certain level; · Concentration: cumulative exposure of a certain financial instrument or risk factor, calculated at market value (MtM – Mark to Market); and · Stressed VaR: statistical metric derived from the VaR calculation, with the purpose is of simulating higher risk in the trading portfolio, taking returns that can be seen in past scenarios of extreme volatility. Management of interest rate risk in the Banking Book (IRRBB) is based on the following metrics: · ÄEVE (Delta Economic Value of Equity): difference between the present value of the sum of repricing flows of instruments subject to IRRBB in a base scenario and the present value of the sum of repricing flows of these instruments in a scenario of shock in interest rates; Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 132

· ÄNII (Delta Net Interest Income): difference between the result of financial intermediation of instruments subject to IRRBB in a base scenario and the result of financial intermediation of these instruments in a scenario of shock in interest rates. In addition, sensitivity and loss control measures are also analyzed. They include: · Mismatching analysis (GAPS): accumulated exposure by risk factor of cash flows expressed at market value, allocated at the maturity dates; · Sensitivity (DV01- Delta Variation): impact on the market value of cash flows, when submitted to an one annual basis point increase in the current interest rates or index rate; · Sensitivity to Sundry Risk Factors (Greeks): partial derivatives of an option portfolio in relation to the prices of underlying assets, implied volatilities, interest rates and time. In order to operate within the defined limits, ITAÚ UNIBANCO HOLDING hedges transactions with customers and proprietary positions, including its foreign investments. Derivatives are commonly used for these hedging activities, which can be either accounting or economic hedges, both governed by the institutional polices of ITAÚ UNIBANCO HOLDING. The structure of limits and alerts obeys the Board of Directors’ guidelines, and it is reviewed and approved on an annual basis. This structure has specific limits aimed at improving the process of monitoring and understanding risk, and at avoiding concentration. These limits are quantified by assessing the forecast balance sheet results, the size of stockholders’ equity, market liquidity, complexity and volatility, and ITAU UNIBANCO HOLDING’s appetite for risk. The consumption of market risk limits is monitored and disclosed daily through exposure and sensitivity maps. The market risk area analyzes and controls the adherence of these exposures to limits and alerts and reports them timely to the Treasury desks and other structures foreseen in the governance. ITAÚ UNIBANCO HOLDING uses proprietary systems to measure the consolidated market risk. The processing of these systems occurs in a high-availability access-controlled environment, which has data storage and recovery processes and an infrastructure that ensures business continuity in contingency (disaster recovery) situations. 2.1 VaR—Consolidated ITAÚ UNIBANCO HOLDING Is calculated by Historical Simulation, i.e. the expected distribution for profits and losses (P&L) of a portfolio over time can be estimated from past behavior of returns of market risk factors for this portfolio. VaR is calculated at a confidence level of 99%, historical period of 4 years (1000 business days) and a holding period of one day. In addition, in a conservative approach, VaR is calculated daily, with and without volatility weighting, and the final VaR is the more restrictive of the values given by the two methods. From 01/01 to 12/31/2020, the average total VaR in Historical Simulation was R$ 282 or 0.2% of total stockholders’ equity (R$ 334 from 01/01 to 12/31/2019 or 0.2% of total stockholders’ equity). VaR Total (Historical Simulation) (Reais million) 12/31/2020 (*) 12/31/2019 (*) Average Minimum Maximum Var Total Average Minimum Maximum Var Total VaR by risk factor group Interest rates 614 292 1,961 431 816 652 960 813 Currencies 29 9 71 24 28 11 59 11 Shares 23 9 49 30 30 14 57 29 Commodities 2 1 4 1 2 1 5 1 Effect of diversification ——(263) ——(576) Total risk 282 166 763 223 334 209 472 278 (*) VaR by Group of Risk Factors considers information from foreign units. Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 133

2.1.1 Interest rate risk The table below shows the accounting position of financial assets and liabilities exposed to interest rate risk, distributed by maturity (remaining contractual terms). This table is not used directly to manage interest rate risks; it is mostly used to permit the assessment of mismatching between accounts and products associated thereto and to identify possible risk concentration. 12/31/2020 12/31/2019 0-30 31-180 181-365 1-5 Over 5 0-30 31-180 181-365 1-5 Over 5 Total Total days days days years years days days days years years Financial assets 478,065 335,803 185,587 568,219 227,397 1,795,071 264,750 382,751 141,277 443,579 203,328 1,435,685 At amortized cost 406,497 251,388 121,432 314,949 125,282 1,219,548 222,026 354,893 102,649 244,862 111,6661,036,096 Compulsory deposits in the Central Bank of Brazil 83,133 — — 83,133 86,836 — — 86,836 Interbank deposits 34,998 5,410 8,178 6,864 187 55,637 23,337 4,448 3,290 3,474 32 34,581 Securities purchased under agreements to resell 196,053 43,625 170 10 77 239,935 22,617 175,643 — 162 198,422 Securities 9,325 16,907 11,440 55,070 33,997 126,739 1,290 13,659 14,817 56,178 44,522 130,466 Loan and lease operations 82,988 185,446 101,644 253,005 91,021 714,104 87,946 161,143 84,542 185,210 66,950 585,791 At fair value through other comprehensive income 13,357 12,557 6,958 54,452 22,618 109,942 2,464 4,524 3,284 46,456 19,932 76,660 At fair value through profit and loss 58,211 71,858 57,197 198,818 79,497 465,581 40,260 23,334 35,344 152,261 71,730 322,929 Securities 40,577 63,455 48,092 178,565 58,382 389,071 33,262 15,420 32,299 137,612 62,482 281,075 Derivatives 17,634 8,403 9,099 20,253 21,115 76,504 6,998 7,914 3,045 14,649 9,248 41,854 Other financial assets — 6 — 6 — — — Financial liabilities 624,542 141,647 122,233 452,797 118,616 1,459,835 508,064 115,876 74,582 309,571 86,135 1,094,228 At amortized cost 607,741 134,640 109,560 426,488 101,753 1,380,182 501,401 106,763 71,460 288,584 77,9911,046,199 Deposits 370,604 80,456 59,955 277,055 20,940 809,010 272,447 38,873 22,877 154,032 18,831 507,060 Securities sold under repurchase agreements 220,219 3,001 1,962 23,811 24,371 273,364 218,055 4,121 1,700 13,309 19,398 256,583 Interbank market funds 9,542 48,407 36,972 56,482 4,632 156,035 9,845 54,141 41,253 66,818 2,805 174,862 Institutional market funds 6,950 2,247 10,142 67,159 51,810 138,308 600 8,472 4,763 53,452 36,957 104,244 Premium bonds plans 426 529 529 1,981—3,465 454 1,156 867 973—3,450 At fair value through profit and loss 16,801 7,007 12,673 26,309 16,863 79,653 6,663 9,113 3,122 20,987 8,144 48,029 Derivatives 16,791 7,002 12,672 26,252 16,788 79,505 6,653 9,100 3,096 20,906 8,073 47,828 Structured notes 10—1 57 75 143 10 13 26 81 71 201 Other financial liabilities—5 ——5 — — — Difference assets / liabilities (*) (146,477) 194,156 63,354 115,422 108,781 335,236 (243,314) 266,875 66,695 134,008 117,193 341,457 Cumulative difference (146,477) 47,679 111,033 226,455 335,236 (243,314) 23,561 90,256 224,264 341,457 Ratio of cumulative difference to total interest-bearing assets -8.2% 2.7% 6.2% 12.6% 18.7% -16.9% 1.6% 6.3% 15.6% 23.8% (*) The difference arises from the mismatch between the maturities of all remunerated assets and liabilities, at the respective period-end date, considering the contractually agreed terms. Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 134

2.1.2 Currency risk The purpose of ITAÚ UNIBANCO HOLDING’s management of foreign exchange exposure is to mitigate the effects arising from variation in foreign exchange rates, which may present high- volatility periods. The currency (or foreign exchange) risk arises from positions that are sensitive to oscillations in foreign exchange rates. These positions may be originated by financial instruments that are denominated in a currency other than the functional currency in which the balance sheet is measured or through positions in derivative instruments (for negotiation or hedge). Sensitivity to currency risk is disclosed in the table VaR Total (Historical Simulation) described in item 2.1 – VaR Consolidated – ITAÚ UNIBANCO HOLDING. 2.1.3 Share Price Risk The exposure to share price risk is disclosed in Note 5, related to Financial Assets Through Profit or Loss—Securities, and Note 8, related to Financial Assets at Fair Value Through Other Comprehensive Income—Securities. 3. Liquidity risk The possibility that the institution may be unable to efficiently meet its expected and unexpected obligations, both current and future, including those arising from guarantees issued, without affecting its daily operations and without incurring significant losses. Liquidity risk is controlled by an area independent from the business area and responsible for establishing the reserve composition, estimating the cash flow and exposure to liquidity risk in different time horizons, and for monitoring the minimum limits to absorb losses in stress scenarios for each country where ITAÚ UNIBANCO HOLDING operates. All activities are subject to verification by independent validation, internal control and audit areas. Liquidity management policies and limits are based on prospective scenarios and senior management’s guidelines. These scenarios are reviewed on a periodic basis, by analyzing the need for cash due to atypical market conditions or strategic decisions by ITAÚ UNIBANCO HOLDING. ITAÚ UNIBANCO HOLDING manages and controls liquidity risk on a daily basis, using procedures approved in superior committees, including the adoption of liquidity minimum limits, sufficient to absorb possible cash losses in stress scenarios, measured with the use of internal and regulatory methods. Additionally the following items for monitoring and supporting decisions are periodically prepared and submitted to senior management: · Different scenarios projected for changes in liquidity; · Contingency plans for crisis situations; · Reports and charts that describe the risk positions; · Assessment of funding costs and alternative sources of funding; · Monitoring of changes in funding through a constant control of sources of funding, considering the type of investor, maturities and other factors. 3.1 Primary sources of funding ITAÚ UNIBANCO HOLDING has different sources of funding, of which a significant portion is from the retail segment. Of total customers’ funds, 37.1% or R$ 379.5 billion, are immediately available to customers. However, the historical behavior of the accumulated balance of the two largest items in this group – demand and savings deposits—is relatively consistent with the balances increasing over time and inflows exceeding outflows for monthly average amounts. Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 135

12/31/2020 12/31/2019 Funding from customers 0-30 days Total % 0-30 days Total % Deposits 370,604 809,010 272,447 507,060 Demand deposits 134,805 134,805 13.2 82,306 82,306 11.5 Savings deposits 179,470 179,470 17.5 144,558 144,558 20.2 Time deposits 55,778 491,234 48.0 44,855 277,166 38.8 Other 551 3,501 0.3 728 3,030 0.4 Funds from acceptances and issuance of securities (1) 1,978 136,638 13.4 4,293 143,569 20.1 Funds from own issue (2) 218 1,985 0.2 235 5,258 0.7 Subordinated debt 6,657 74,916 7.3 2 59,462 8.3 Total 379,457 1,022,549 100.0 276,977 715,349100.0 (1) Includes mortgage notes, guaranteed real estate credit bills, agribusiness, financial recorded in interbank markets funds and Obligations on the issue of debentures, Securities abroad and strutured operations certificates recorded in Institutional Markets Funds. (2) Refer to deposits received under securities repurchase agreements with securities from own issue. 3.2 Control over liquidity ITAÚ UNIBANCO HOLDING manages its liquidity reserves based on estimates of funds that will be available for investment, assuming the continuity of business in normal conditions. During the period of 2020, ITAÚ UNIBANCO HOLDING maintained sufficient levels of liquidity in Brazil and abroad. Liquid assets totaled R$ 323.2 billion and accounted for 85.2% of the short term redeemable obligations, 31.6% of total funding, and 23.4% of total assets. The table below shows the indicators used by ITAÚ UNIBANCO HOLDING in the management of liquidity risk: Liquidity indicators 12/31/2020 % 12/31/2019 % Net assets (1) / customers funds within 30 days (2) 85.2 62.4 Net assets (1) / total customers funds (3) 31.6 24.2 Net assets (1) / total financial assets (4) 23.4 16.6 (1) Net assets (present value): Cash, Securities purchased under agreements to resell – Funded position and Government securities—available. Detailed in the table Non discounted future flows – Financial assets. (2) Table Funding from customers table (Total Funding from customers 0-30 days). (3) Table funding from customers (Total funding from customers). (4) Detailed in the table Non discounted future flows – Financial assets, total present value regards R$ 1,381,769 (R$ 1,040,865 at 12/31/2019). Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 136

Assets and liabilities according to their remaining contractual maturities, considering their undiscounted flows, are presented below: Undiscounted future flows, except for derivatives which are fair value 12/31/2020 12/31/2019 (1) Over 720 Over 720 Financial assets 0—30 31—365 366—720 Total 0—30 31—365 366—720 Total days days Cash 46,224 ——46,224 30,367 ——30,367 Interbank investments 234,755 43,276 6,273 1,092 285,396 69,756 151,497 1,444 1,191 223,888 Securities purchased under agreements to resell – Collateral held (2) 44,743 ——44,743 26,797 ——26,797 Securities purchased under agreements to resell – Collateral repledge 150,474 31,561 — 182,035 17,871 144,234 — 162,105 Interbank deposits (4) 39,538 11,715 6,273 1,092 58,618 25,088 7,263 1,444 1,191 34,986 Securities 239,964 16,348 17,144 101,908 375,364 131,195 17,669 19,846 108,011 276,721 Government securities—available 226,615 393 379 5,779 233,166 111,487 300 302 4,763 116,852 Government securities – under repurchase commitments 93 3,905 6,749 15,132 25,879 7,744 6,616 12,445 25,366 52,171 Corporate securities—available 13,256 11,113 8,352 51,927 84,648 11,964 10,181 4,967 56,839 83,951 Corporate securities – under repurchase commitments—937 1,664 29,070 31,671—572 2,132 21,043 23,747 Derivative financial instruments—Net position 17,634 17,502 6,478 34,890 76,504 6,998 10,959 5,355 18,542 41,854 Swaps 4,064 2,952 5,117 33,886 46,019 107 4,039 4,464 17,848 26,458 Options 10,103 8,783 992 540 20,418 4,696 3,043 500 217 8,456 Forwards (onshore) 1,323 757 5—2,085 940 1,207 15—2,162 Other derivatives 2,144 5,010 364 464 7,982 1,255 2,670 376 477 4,778 Loans and lease operations (3) 60,896 236,173114,523 317,492 729,084 63,401 197,090 93,203 236,982 590,676 Other financial assets—6 — 6 — ——Total financial assets 599,473 313,305 144,418 455,382 1,512,578 301,717 377,215 119,848 364,726 1,163,506 (1) The assets portfolio does not take into consideration the balance of compulsory deposits in Central Bank, amounting to R$ 90,059 (R$ 91,248 at 12/31/2019), which release of funds is linked to the maturity of the liability portfolios. The amounts of PGBL and VGBL are not considered in the assets portfolio because they are covered in Note 26. (2) Net of R$ 11,119 (R$ 8,544 at 12/31/2019) which securities are linked to guarantee transactions at B3 S.A.—Brasil, Bolsa, Balcão and the BACEN. (3) Net of payment to merchants of R$ 71,820 (R$ 69,050 at 12/31/2019) and the amount of liabilities from transactions related to credit assignments R$ 1,623 (R$ 2,451 at 12/31/2019). (4) Includes R$ 32,477 (R$ 18,938 at 12/31/2019) related to Compulsory Deposits with Central Banks of other countries. Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 137

Undiscounted future flows, except for derivatives which are fair value 12/31/2020 12/31/2019 Over 720 Over 720 Financial liabilities 0 – 30 31 – 365 366 – 720 Total 0 – 30 31 – 365 366 – 720 Total days days Deposits 369,957 145,085 36,258 344,261 895,561 266,690 69,367 20,555 211,531 568,143 Demand deposits 134,805 ——134,805 82,306 ——82,306 Savings deposits 179,470 ——179,470 144,558 ——144,558 Time deposit 53,978 143,446 36,182 343,974 577,580 37,570 68,757 20,502 211,395 338,224 Interbank deposits 1,633 1,639 76 287 3,635 2,247 610 53 136 3,046 Other deposits 71 ——71 9 ——9 Compulsory deposits (36,337) (16,874) (4,412) (32,436) (90,059) (38,576) (14,067) (4,110) (34,495) (91,248) Demand deposits (6,926) ——(6,926) (4,412) ——(4,412) Savings deposits (22,672) ——(22,672) (26,234) ——(26,234) Time deposit (6,739) (16,874) (4,412) (32,436) (60,461) (7,930) (14,067) (4,110) (34,495) (60,602) Securities sold under repurchase agreements (1) 260,846 5,024 5,183 22,591 293,644 246,499 6,509 5,218 17,585 275,811 Government securities 182,848 2,070 2,414 22,564 209,896 200,499 344 1,720 17,553 220,116 Corporate securities 22,056 2,954 2,769 27 27,806 17,978 2,810 3,498 32 24,318 Foreign 55,942 ——55,942 28,022 3,355 — 31,377 Funds from acceptances and issuance of securities (2) 2,391 40,463 35,189 68,573 146,616 4,335 47,697 39,505 67,435 158,972 Loans and onlending obligations (3) 11,891 64,735 6,239 6,388 89,253 6,368 65,182 6,259 7,462 85,271 Subordinated debt (4) 6,797 8,428 28,994 45,762 89,981 251 6,594 11,794 53,745 72,384 Derivative financial instruments—Net position 16,791 19,674 6,895 36,145 79,505 6,653 12,196 9,458 19,521 47,828 Swaps 7,344 3,612 5,573 35,260 51,789 326 5,218 8,349 19,034 32,927 Option 6,355 12,381 998 528 20,262 3,668 4,567 571 255 9,061 Forward (onshore) 892 13 — 905 753 1 — 754 Other derivatives 2,200 3,668 324 357 6,549 1,906 2,410 538 232 5,086 Other financial liabilities—5 — 5 — ——Total financial liabilities 632,336 266,540 114,346 491,284 1,504,506 492,220 193,478 88,679 342,784 1,117,161 (1) Includes own and third parties’ portfolios. (2) Includes mortgage notes, Guaranteed real estate notes, agribusiness, financial recorded in interbank market funds and Obligations on issue of debentures, Securities abroad and Structured Transactions certificates recorded in institutional markets funds. (3) Recorded in funds from interbank markets. (4) Recorded in funds from institutional markets. 12/31/2020 12/31/2019 Off balance commitments 0 – 30 31 – 365 366 – 720 Over 720 Total 0 – 30 31 – 365 366 – 720 Over 720 Total days days Financial Guarantees 2,859 24,491 6,428 35,155 68,933 1,286 19,447 9,359 36,628 66,720 Commitments to be released 128,792 27,144 11,776 153,193 320,905 125,664 22,818 7,064 149,876 305,422 Letters of credit to be released 41,477 — - 41,477 15,013 — - 15,013 Contractual commitments—Fixed and Intangible assets (Notes 13 and 14)—36 — 36—273 — 273 Total 173,128 51,671 18,204 188,348 431,351 141,963 42,538 16,423 186,504 387,428 Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 138

c) Capital Management Governance ITAÚ UNIBANCO HOLDING is subject to the regulations of BACEN, which determines minimum capital requirements, procedures to obtain information to assess the global systemic importance of banks, fixed asset limits, loan limits and accounting practices, and requires banks to conform to the regulations based on the Basel Accord for capital adequacy. Additionally, CNSP and SUSEP issue regulations on capital requirements that affect our insurance operations and private pension and premium bonds plans. The capital statements were prepared in accordance with BACEN’s regulatory requirements and with internationally accepted minimum requirements according to the Bank for International Settlements (BIS). I – Composition and Capital Adequacy The Board of Directors is the body responsible for approving the institutional capital management policy and guidelines for the capitalization level of ITAÚ UNIBANCO HOLDING. The Board is also responsible for the full approval of the ICAAP (Internal Capital Adequacy Assessment Process) report, the purpose of which is to assess the capital adequacy of ITAÚ UNIBANCO HOLDING. The result of the last ICAAP – which was dated December 2019 – indicated that ITAÚ UNIBANCO HOLDING has, in addition to capital to cover all material risks, a significant capital surplus, thus assuring the solidity of the institution’s equity position. In order to ensure that ITAÚ UNIBANCO HOLDING is sound and has the capital needed to support business growth, the institution maintains PR levels above the minimum level required to face risks, as demonstrated by the Common Equity, Tier I Capital and Basel ratios. 12/31/2020 12/31/2019 Available capital (amounts) Common Equity Tier 1 119,960 117,328 Tier 1 137,157 128,696 Total capital (PR) 151,244 140,596 Risk-weighted assets (amounts) Total risk-weighted assets (RWA) 1,042,207 891,300 Risk-based capital ratios as a percentage of RWA Common Equity Tier 1 ratio (%) 11.5% 13.2% Tier 1 ratio (%) 13.2% 14.4% Total capital ratio (%) 14.5% 15.8% Additional CET1 buffer requirements as a percentage of RWA Capital conservation buffer requirement (%) (*) 1.25% 2.5% Countercyclical buffer requirement (%) 0.0% 0.0% Bank G-SIB and/or D-SIB additional requirements (%) 1.0% 1.0% Total of bank CET1 specific buffer requirements (%) 2.25% 3.5% (*) For purposes of calculating the Conservation capital buffer, BACEN Resolution 4,783 establishes, for defined periods, percentages to be applied to the RWA value with a gradual increase until April/22, when it reaches 2.5%. The Basel Ratio reached 14.5% at 12/31/2020, 1.3 p.p. lower than at 12/31/2019, mainly due to the foreign exchange impact, the provision of interest on capital, dividends referring to fiscal year 2019, and increase in risk-weighted assets, partially diminished by net income in the period and issuance of level 1 and level 2 debts. Additionally, ITAÚ UNIBANCO HOLDING has a surplus over the required minimum Referential Equity of R$ 67,867 (R$ 69,292 at 12/31/2019), well above the ACP of R$ 23,450 (R$ 31,195 at 12/31/2019), generously covered by available capital. In December 2020, ITAÚ UNIBANCO HOLDING issued R$ 2.1 billion in Subordinated Financial Notes, which have a repurchase option as from 2025. These subordinated notes are subject to approval by the Central Bank of Brazil for the composition of ITAÚ UNIBANCO HOLDING´S Tier II Capital, with an estimated increase of 0.20 p.p. in its Total Capital Ratio. The fixed assets ratio shows the commitment percentage of adjusted Referential Equity with adjusted permanent assets. ITAÚ UNIBANCO HOLDING falls within the maximum limit of 50% of adjusted PR, established by BACEN. At 12/31/2020, fixed assets ratio reached 24.0% (27.9% at 12/31/2019), showing a surplus of R$ 39,274 (R$ 31,104 at 12/31/2019). Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 139

Funds from the issuance of subordinated debt securities are considered Tier II capital for purpose of capital to risk-weighted assets ratio, as shown below. According to current legislation, the balance of subordinated debt in December 2012 was used for calculating the reference equity as of December 2020, totaling R$ 47,296. Name of security / currency Principal amount Issue Maturity Return p.a. Account balance (original currency) 12/31/2020 12/31/2019 Subordinated financial bills—BRL - 2012 2020 111% of CDI—2—IPCA + 6% to 6.17%—49 6 2011 2021 109.25% to 110.5% of CDI 14 14 2,307 2012 2022 IPCA + 5.15% to 5.83% 5,484 4,994 20 IGPM + 4.63% 38 30 2,333 Total 5,536 5,089 Subordinated euronotes—USD 990 2010 2020 6.20%—4,041 1,000 2010 2021 5.75% 5,360 4,152 730 2011 2021 5.75% to 6.20% 3,805 2,952 550 2012 2021 6.20% 2,858 2,218 2,600 2012 2022 5.50% to 5.65% 13,764 10,673 1,851 2012 2023 5.13% 9,677 7,502 7,721 Total 35,464 31,538 Debt instruments eligible as capital—USD 740 2019 2029 4.50% 3,865—740 Total 3,865—Debt instruments eligible as capital—BRL 50 2019 2028 CDI + 0.72% 52—2,280 2029 CDI + 0.75% 2,379—2,330 Total 2,431—Total 47,296 36,627 II—Risk-Weighted Assets (RWA) For calculating minimum capital requirements, RWA must be obtained by taking the sum of the following risk exposures: RWA = RWACPAD + RWAMINT + RWAOPAD · portion related to exposures to credit risk, calculated using the standardized approach; · portion related to capital required for market risk, composed of the maximum between the internal model and 80% of the standardized model, regulated by BACEN Circular nº 3,646 and nº 3,674; · = portion related to capital required for operational risk, calculated based on the standardized approach. Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 140

RWA 12/31/2020 12/31/2019 Credit Risk—standardized approach 921,934 784,730 Credit risk (excluding counterparty credit risk) 778,153 690,474 Counterparty credit risk (CCR) 45,674 31,356 Of which: standardized approach for counterparty credit risk (SA-CCR) 27,119 16,523 Of which: other CCR 18,555 14,833 Credit valuation adjustment (CVA) 5,960 3,494 Equity investments in funds—look-through approach 4,897 7,669 Equity investments in funds—mandate-based approach 623 205 Equity investments in funds—fall-back approach 716 1,133 Securitisation exposures—standardized approach 1,506—Amounts below the thresholds for deduction 84,405 50,399 Market Risk 27,481 25,002 Of which: standardized approach (RWAMPAD) 34,351 28,328 Of which: internal models approach (RWAMINT) 22,362 25,002 Operational Risk 92,792 81,568 Total 1,042,207 891,300 III – Recovery Plan In response to the latest international crises, the Central Bank published Resolution No. 4,502, which requires the development of a Recovery Plan by financial institutions within Segment 1, with total exposure to GDP of more than 10%. This plan aims to reestablish adequate levels of capital and liquidity above regulatory operating limits in the face of severe systemic or idiosyncratic stress shocks. In this way, each institution could preserve its financial viability while also minimizing the impact on the National Financial System. Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 141

IV—Stress testing The stress test is a process of simulating extreme economic and market conditions on ITAÚ UNIBANCO HOLDING’s results, liquidity and capital. The institution has been carrying out this test in order to assess its solvency in plausible scenarios of crisis, as well as to identify areas that are more susceptible to the impact of stress that may be the subject of risk mitigation. For the purposes of the test, the economic research area estimates macroeconomic variables for each stress scenario. The elaboration of stress scenarios considers the qualitative analysis of the Brazilian and the global conjuncture, historical and hypothetical elements, short and long term risks, among other aspects, as defined in CMN Resolution 4,557. In this process, the main potential risks to the economy are assessed based on the judgment of the bank’s team of economists, endorsed by the Chief Economist of ITAÚ UNIBANCO HOLDING and approved by the Board of Directors. Projections for the macroeconomic variables (such as GDP, basic interest rate, exchange rates and inflation) and for variables in the credit market (such as raisings, lending, rates of default, margins and charges) used are based on exogenous shocks or through use of models validated by an independent area. Then, the stress scenarios adopted are used to influence the budgeted result and balance sheet. In addition to the scenario analysis methodology, sensitivity analysis and the Reverse Stress Test are also used. ITAÚ UNIBANCO HOLDING uses the simulations to manage its portfolio risks, considering Brazil (segregated into wholesale and retail) and External Units, from which the risk-weighted assets and the capital and liquidity ratios are derived. The stress test is also an integral part of the ICAAP, the main purpose of which is to assess whether, even in severely adverse situations, the institution would have adequate levels of capital and liquidity, without any impact on the development of its activities. This information enables potential offenders to the business to be identified and provides support for the strategic decisions of the Board of Directors, the budgeting and risk management process, as well as serving as an input for the institution’s risk appetite metrics. V – Leverage Ratio The Leverage Ratio is defined as the ratio of Capital Tier I to Total Exposure, calculated pursuant to BACEN Circular 3,748, of February 27, 2015. The purpose of this ratio is to be a simple measure of leverage not sensitive to risk, thus it does not consider weighting or mitigation factors. According to instructions in BACEN Circular Letter 3,706, of May 5, 2015, ITAÚ UNIBANCO HOLDING has sent the Leverage Ratio monthly to BACEN, whose minimum requirement is 3%. d) Management Risks of insurance and private pension I – Management Structure, roles and responsibilities In line with good domestic and international practices, ITAÚ UNIBANCO HOLDING has a risk management structure that ensures that the risks arising from insurance and pension plans products are properly monitored and reported to the appropriate bodies. The management process of insurance and pension plans risks is independent and focuses on the specific nature of each risk. ITAÚ UNIBANCO HOLDING has committees to define the management of funds from the technical reserves for insurance and private pensions, to issue guidelines for managing these funds with the objective of achieving long term returns, and to define valuation models, risk limits and strategies on allocation of funds to specific financial assets. The members of these committees are not only executives and those directly responsible for the business management process, but also heads and coordinators of commercial and financial areas. Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 142

II – Risks of Insurance and Private Pensions ITAÚ UNIBANCO HOLDING offers its products to customers through a bancassurance structure or direct distribution. Life, personal accident, loan and multiple peril insurance products are mainly distributed by a bancassurance operation. Life insurance and pension plans are, in general, medium or long-term products and the main risks involved in the business may be classified as demographic, financial and behavioral. · Demographic risk relates to: i) a greater than expected increase in life expectancies for products with survivorship coverage (mostly pension plans); and ii) a greater than expected decrease in mortality rates for products with life coverage (mostly life insurance). · Financial risk: is inherent in the underwriting risk of products that offer a contractual financial guarantee, this risk being considered insurance risk. · Behavioral risk relates to a greater than expected increase in the rates of conversion into annuity income, resulting in increased payments of retirement benefits. Estimated actuarial assumptions are based on the past experience of ITAÚ UNIBANCO HOLDING, on market benchmarks and on the experience of the actuaries. a) Effect of changes on actuarial assumptions To measure the effects of changes in the key actuarial assumptions, sensitivity tests were conducted in the amounts of current estimates of future liability cash flows. The sensitivity analysis considers a vision of the impacts caused by changes in assumptions, which could affect the income for the period and stockholders’ equity at the balance sheet date. This type of analysis is usually conducted under the ceteris paribus condition, in which the sensitivity of a system is measured when one variable of interest is changed and all the others remain unchanged. The results obtained are shown in the table below: Impact in Income and Stockholders’ Equity (1) Sensitivity Test 12/31/2020 12/31/2019 Private Pension Insurance Private Pension Insurance Mortality Rates 5% increase 56 2 25—5% decrease (59) (2) (37) (1) Risk-free Interest Rates 0.1% increase 98 10 61 12 0.1% decrease (100) (11) (63) (12) Conversion in Income Rates 5% increase (9)—20—5% decrease 9—(21)—Claims 5% increase—(52)—(47) 5% decrease—52—47 (1) Amounts net of tax effects. Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 143

b) Risk concentration For ITAÚ UNIBANCO HOLDING, there is no product concentration in relation to insurance premiums, reducing the risk of product concentration and distribution channels. 01/01 a 12/31/2020 01/01 a 12/31/2019 01/01 a 12/31/2018 Insurance Retained Retention Insurance Retained Retention Insurance Retained Retention premiums premium (%) premiums premium (%) premiums premium (%) Individuals Group accident insurance 849 847 99.8 867 867 100.0 690 689 99.9 Individual accident 192 187 97.3 222 222 100.0 275 280 101.8 Credit life 624 624 100.0 948 946 99.8 881 879 99.8 Group life 956 955 99.9 948 947 99.9 934 937 100.3 III) Market, credit and liquidity risk a) Market risk Market risk is analyzed, in relation to insurance operations, using the following metrics and sensitivity and loss control measures: Value at Risk (VaR), Losses in Stress Scenarios (Stress Test), Sensitivity (DV01- Delta Variation) and Concentration. In the table, the sensitivity analysis (DV01 – Delta Variation) is presented in relation to insurance operations that demonstrate the impact on the market value of cash flows when submitted to a one basis point increase in the current interest rate or indexer rate and one percentage point in the share price and currency. 0 12/31/2020 12/31/2019 Class Account DV01 Account DV01 balance balance Government securities National Treasury Notes (NTN-C) 7,025 (3.11) 5,495 (2.57) National Treasury Notes (NTN-B) 5,215 (5.42) 8,675 (9.42) National Treasury Notes (NTN-F) 134 (0.08) —National Treasury Bills (LTN) 2,098 (0.31) —Chile Government securities (BTU) — 152 (0.04) Corporate securities Indexed to IPCA 22 (0.01) 83 (0.01) Indexed to PRE 85—142 (0.01) Indexed to CLP — 79 -Indexed to CLF — 6—Shares 1,320 13 6 -Post-fixed assets 2,414—2,297—Under agreements to resell 697—777 -Total 19,010 17,712 Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 144

b) Liquidity Risk Liquidity risk is identified by ITAÚ UNIBANCO HOLDING as the risk of lack of liquid resources available to cover its current obligations at a given moment. For insurance operations, the liquidity risk is managed continuously by monitoring payment flows against liabilities, compared to the inflows generated by its operations and financial assets portfolio. Financial assets are managed in order to optimize the risk-return ratio of investments, considering, on a careful basis, the characteristics of their liabilities. The risk integrated control considers the concentration limits by issuer and credit risk, sensitivities and market risk limits and control over asset liquidity risk. Thus, investments are concentrated in government and private securities with good credit quality in active and liquid markets, keeping a considerable amount invested in short-term assets, available on demand, to cover regular needs and any liquidity contingencies. Additionally, ITAÚ UNIBANCO HOLDING constantly monitors the solvency conditions of its insurance operations. Liabilities Assets 12/31/2020 12/31/2019 Liabilities Liabilities Assets Liabilities Liabilities Assets Insurance operations Backing asset amounts (1) DU (2) DU (2) amounts (1) DU (2) DU (2) Unearned premiums LFT, repurchase agreements, NTN-B, CDB, LF and debentures 2,298 57.8 19.1 2,343 59.1 22.9 IBNR, PDR e PSL LFT, repurchase agreements, NTN-B, CDB, LF and debentures 838 50.9 27.2 876 49.9 29.0 Redemptions and Other Unsettled Amounts LFT, repurchase agreements, NTN-B, CDB, LF and debentures 16 16.3 18.3 13 7.9 22.9 Mathematical reserve for benefits to be granted and benefits granted LFT, repurchase agreements, NTN-B, NTN-C, debentures 17 172.6 24.0 204 16.9 2.6 Financial surplus LFT, repurchase agreements, NTN-B, NTN-C, CDB, LF and debentures 2 204.1 18.3 2 222.4 22.9 Other provisions LFT, repurchase agreements, NTN-B, CDB, LF and debentures 132 7.0 96.4 250 6.9 104.5 Subtotal Subtotal 3,303 3,688 Pension plan, VGBL and individual life operations Related expenses LFT, repurchase agreements, NTN-B, CDB, LF and debentures 88 109.4 81.3 89 126.2 82.6 Unearned premiums LFT, repurchase agreements, NTN-B, CDB and debentures 12 17.4 22.2 13 11.1 20.8 Unsettled claims LFT, repurchase agreements, NTN-B, CDB and debentures 68 17.4 22.2 47 11.1 20.8 IBNR LFT, repurchase agreements, NTN-B, CDB and debentures 22 17.4 22.2 22 11.1 20.8 Redemptions and Other Unsettled Amounts LFT, repurchase agreements, NTN-B, CDB and debentures 332 17.4 22.2 318 11.1 20.8 Mathematical reserve for benefits granted LFT, repurchase agreements, LTN, NTN-B, NTN-C, NTN-F, CDB, LF and debentures 3,278 109.4 81.4 2,781 126.2 82.8 Mathematical reserve for benefits to be granted – PGBL/ VGBL LFT, repurchase agreements, LTN, NTN-B, NTN-C, NTN-F, CDB, LF and debentures (3) 205,670 166.5 56.2 204,394 180.6 57.0 Mathematical reserve for benefits to be granted – traditional LFT, repurchase agreements, NTN-B, NTN-C, debentures 6,268 188.5 80.9 5,099 199.8 110.1 Other provisions LFT, repurchase agreements, NTN-B, NTN-C, CDB, LF and debentures 1,304 188.4 80.9 1,273 199.7 110.1 Financial surplus LFT, repurchase agreements, NTN-B, NTN-C, CDB, LF and debentures 655 188.5 80.9 610 199.8 110.1 Subtotal Subtotal 217,697 214,646 Total technical reserves Total backing assets 221,000 218,334 (1) Gross amounts of Credit Rights, Deposits in Guarantee and Reinsurance. (2) DU = Duration in months. (3) Excluding PGBL / VGBL reserves allocated in variable income. Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 145

c) Credit Risk I—Reinsurers Reinsurance operations are controlled through an internal policy, in compliance with the provisions of the regulatory authority governing the reinsurers with which ITAÚ UNIBANCO HOLDING operates. We present below a breakdown of the risks assigned by ITAÚ UNIBANCO HOLDING’s subsidiaries to reinsurance companies: - Insurance Operations: reinsurance premiums operations are basically represented by: IRB Brasil Resseguros S.A. with 59% (86% at 12/31/2019), Mapfre Re do Brasil Companhia de Resseguros with 21% and Austral Resseguradora S.A. with 20% (1% at 12/31/2019). - Private Pension Operations: related to reinsurance premiums are entirely represented by Mapfre Re do Brasil Companhia de Resseguros with 45%, Austral Resseguradora S.A. with 30% (40% at 12/31/2019), IRB Brasil Resseguros S.A. with 25% (30% at 12/31/2019) and General Reinsurance AG without % of interest in the current period (30% at 12/31/2019). II – Premiums Receivable ITAÚ UNIBANCO HOLDING considers the credit risk arising from past-due premiums immaterial, since cases with coverage payment in default may be canceled, pursuant to Brazilian regulations. III—Risk level of financial assets The table below shows insurance financial assets, individually evaluated, classified by rating: 12/31/2020 Financial Assets at Amortized Cost Financial assets at fair Financial Assets at Fair Interbank deposits and securities Value Through Other value through profit or Total Internal rating purchased under agreements to Securities Comprehensive loss (*) resell Income Low 3,517 30,614 205,099 1,194 240,424 Medium — 3—3 High — ——Total 3,517 30,614 205,102 1,194 240,427 % 1.5 12.7 85.3 0.5 100.0 (*) Includes Derivatives in the amount of R$ 1,336. 12/31/2019 Financial Assets at Amortized Cost Financial assets at fair Financial Assets at Fair Interbank deposits and securities Value Through Other value through profit or Total Internal rating purchased under agreements to Securities Comprehensive loss (*) resell Income Low 3,027 31,342 197,940—232,309 Medium — 2—2 High — ——Total 3,027 31,342 197,942 - 232,311 % 1.3 13.5 85.2—100.0 (*) Includes Derivatives in the amount of R$ 960. Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 146

Note 33 – Supplementary information a) “Coronavirus” COVID-19 relief efforts ITAÚ UNIBANCO HOLDING monitors the economic effects of this COVID-19 pandemic in Brazil and the other countries where it operates, which may adversely affect its Profit or Loss. At the beginning of the COVID-19 outbreak, the Institutional Crisis Management Committee was set up. The Executive Committee established an intensified agenda to manage the crisis, which is responsible for the monitoring the pandemic and its impacts on its operations, in addition to the government actions to mitigate the effects of this pandemic. In Brazil, measures were taken to mitigate the impacts caused by COVID-19 throughout 2020, by the Federal Government, the National Monetary Council (CMN) and the Central Bank of Brazil (BACEN), particularly: i) CMN Resolution No. 4,782/20, and amendments made by CMN Resolutions No. 4,791/20 and No. 4.856/20, which established, for a determined period of time, criteria for characterization of restructuring of loan operations; ii) CMN Resolution No. 4,838/20, which regulates the Working Capital Program for Business Preservation (CGPE); iii) CMN Resolution No. 4,846/20 which provides for loan operations for financing of payroll carried out by financial institutions, under the Emergency Employment Support Program (PESE); iv) Law No. 13,999/20 that instituted the National Support Program for Micro and Small Companies (Pronampe) with the purpose of developing and strengthening small businesses; v) Law No. 14,042/20 that established the Emergency Program for Access to Credit (Peac), with the purpose of making easier the access to credit and preserving companies, for the protection of jobs and income. The Peac has two modalities: Emergency Program for Access to Credit in the modality of guarantee (Peac-FGI) and Emergency Program for Access to Credit in the modality guarantee of receivables (Peac-Maquininhas); and vi) BACEN Circular No. 3,990/20 and amendments made by BACEN Circular 3,992/20 which permits to carry out repurchase agreements in foreign currency by BACEN; ITAÚ UNIBANCO HOLDING identified the following impacts on its results, as well as effects on estimates and critical judgments for the preparation of the Consolidated Financial Statements: (a) increase in loan and financing operations, especially for micro, small and medium-sized companies due to the measures adopted for mitigation of the impacts of COVID-19 by the authorities with the creation of programs such as PESE, Pronampe, Peac-FGI and CGPE in the amount of R$ 24,169. Through timely monitoring of credit standards and behavior of clients, ITAÚ UNIBANCO HOLDING maintained the regularity of its operations, despite the adverse conditions, and helped clients in the sustainable search for their financial rebalancing; (b) with the purpose of treating indebtedness in a structured way and giving financial impetus to clients, initiatives were established that allowed the extension of grace periods, terms and better interest rate conditions for individuals, and micro and small business clients. In March 2020, the Program 60+ was established, which, among other measures, allowed a 60-day grace period for defaulting agreements and in mid-April the Travessia (Crossing) Program. Travessia allowed the extension of grace periods between 120 and 180 days and terms of operations between 5 and 6 years, respectively, for individual and micro and small companies clients, under better interest rate conditions; (c) 28.05% increase in applications of renegotiation and extension of terms for loan operations as the economic situation changed; (d) the allowance for loan losses was increased by R$ 4,194 due to the level of risk and default, due to the changes in the financial perspectives of clients and the visible deterioration of macroeconomic variables. To fully reflect the risk of its loan operations, ITAÚ UNIBANCO HOLDING adopts the expected loss model for provisioning of operations since the moment they are granted and it is periodically updated according to the macroeconomic variables and circumstances of the client, and in 2020, in view of the pandemic, a weighting in the economic scenarios was added. In December 2020, the level of coverage of provisions in the loan portfolio of ITAÚ UNIBANCO HOLDING accounted for 255% as compared to 187% in the same period of 2019. Specifically for the expected loss of operations that have not shown any signs of deterioration so far (default or downgrading of the client’s rating), provisioning posted an increase of 28.8% in 12 months. The credit risk governance allowed ITAÚ UNIBANCO HOLDING a quick response for monitoring the impacts of the COVID-19 pandemic on the loan portfolio, permitting quick access to the information needed for discussions and actions of the crisis management daily forums; Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 147

(e) the mark-to-market component of the securities portfolio was reduced to -1.3% in the first quarter of 2020, partially due to rate fluctuations and high price volatility in the markets in the beginning of the pandemic, influencing the measurement of items stated at fair value in their different levels; (f) due to the COVID-19 pandemic, instability in the variable income market was noted causing a migration to fixed income instruments with liquidity. This movement resulted in the increase in the Bank Deposit Certificates portfolio. Additionally, there were impacts on funding, with an increase in deposits too. With the purpose of mitigating the system’s liquidity risk, BACEN made available to financial institutions credit lines through repurchase agreements in foreign currency and purchase of financial bills with guarantee, and operations in the total amount of R$ 30,547 were contracted; (g) increase in the recognition of deferred income tax and social contribution due to the greater volume of deductible temporary differences recorded for the period. The pandemic reduced the projections of taxable income, however, it was not responsible for the generation of tax loss and social contribution loss carryforwards in ITAÚ UNIBANCO HOLDING; and (h) increase in expenses with claims related to COVID-19 of R$ 104, mainly related to credit life and life insurance. There was a reduction in the face-to-face service staff and an increase in the spacing between people in call centers to reduce the circulation of people and the possibilities of contagion. The average number of people circulating in administrative centers was reduced, since they started to work remotely. Approximately 97% of employees in the central management, service centers and digital branches are working from home. It should be noted that despite the aforementioned measures, ITAÚ UNIBANCO HOLDING maintains its operating activities. In order to reduce the effects of the crisis and ensure the employee’s health and safety, self-declaration was encouraged for employees who consider themselves at risk and those who cannot work remotely were put on vacation. With the purpose of supporting those who possibly had additional expenses due to the current crisis, the 13th salary was advanced in full. Additionally, a process of communication and transparency with employees was established through e-mails, internal employee’s portal and periodic videos prepared by our President and CEO communicating news related to COVID-19. At the branches, masks were delivered to all employees who work in customer service, acrylic protections were implemented and cleaning protocols were reviewed. The adaptation of ITAÚ UNIBANCO HOLDING in the crisis is the result not only of investments in technology, which allows for these virtual interactions, but also of investments in flexibility in the work environment, such as work from home, communities integrated between different areas of the bank and new layouts in the administrative centers that promote the employees’ mobility. In 2020, ITAÚ UNIBANCO HOLDING created the initiative “Todos pela Saúde” (All for Health) from the donation of R$ 1 billion, with the purpose of combating the new Coronavirus and its effects on Brazilian society. “Todos Pela Saúde” is conducted based on four axes: Informing, Protecting, Caring, and Resuming. Note 34 – Subsequent Event Issue of Subordinate Notes Tier 2 On January 12, 2021, ITAÚ UNIBANCO HOLDING priced the issue of subordinate notes Tier II 2, issued on January 15, maturing in ten years and three months, in the amount of US$ 500 million, at the fixed rate of 3.875%, effective for five years and three months from the issue date. As from this date, inclusive, the interest rate will be recalculated for another 5 years based on the interest rate of securities issued by the Treasury of the United States of America for the same period. ITAÚ UNIBANCO HOLDING may repurchase the Notes as from the 5th year until the 5th year and three months of the issue date, and it will be subject to BACEN’s approval. BACEN’s approval will be requested for the Notes to make up the Supplementary Capital of Referential Equity of ITAÚ UNIBANCO HOLDING, thus increasing by 0.25 p.p. its Basel Ratio, considering the exchange rate of January 8, quoted at R$ 5.37. The Issue is neither subject to registration rules with the Securities Exchange Commission (SEC), in the United States, nor to registration with the Brazilian Securities Commission (CVM), in Brazil, in compliance with applicable law and regulations. Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 148

The Notes were offered only to qualified institutional investors and to non-American investors outside the territory of the United States of America. ITAÚ UNIBANCO HOLDING will use the funds raised by the Notes to finance or refinance green, social and/or sustainable projects. XP INC Corporate Reorganization At the Extraordinary Stockholders’ Meeting held on January 31, 2021, the corporate reorganization was decided in order to segregate the business line related to interest in XP INC’s capital to the new company that will be named XPart S.A. The XPart S.A. will be constituted by the portion of investment in XP INC and for the cash amount corresponding to R$ 10, and is subject to a favorable opinion from the regulatory authority obtained by the controllers for the completion of the operation. The percentage of XP INC’s capital to be held by XPart S.A. will be 40.52%, totaling R$ 9,371 on the base of December 31, 2020. ITAÚ UNIBANCO HOLDING’s stockholders will then hold an ownership interest in XPart S.A., with the completion of the operation. After registration as a publicly-held company and authorization to list securities issued by XPart S.A., the ownership interest on XPart S.A. will be distributed to the shareholders of ITAÚ UNIBANCO HOLDING. The shares issued by XPart S.A. will be attributed to ITAÚ UNIBANCO HOLDING’s stockholders in the same number, type and proportion of the shares previously held by them in ITAÚ UNIBANCO HOLDING. Itaú Unibanco Holding S.A. – Complete Financial Statements in IFRS – December 31, 2020 149