Data across VALOR-HCM, EXPLORER-HCM, AUGUSTUS and other studies continue to demonstrate the safety and efficacy of the company’s cardiovascular portfolio

PRINCETON, N.J.--(BUSINESS WIRE)-- Bristol Myers Squibb (NYSE: BMY) today announced the presentation of research demonstrating the strength of the company’s cardiovascular franchise at the American Heart Association’s (AHA) annual Scientific Sessions, taking place in-person and virtually November 5-7, 2022. Findings from clinical, patient-reported outcomes and real-world studies will be presented across the cardiovascular portfolio. Notably, one abstract from the CAMZYOS® (mavacamten) development program was accepted as a featured science presentation demonstrating advancements in the treatment of obstructive hypertrophic cardiomyopathy (HCM).

“The AHA annual Scientific Sessions is an important congress for us to share new data that is adding to the growing body of evidence demonstrating the continued positive, long-term impact our treatments are having for cardiovascular patients globally,” said Roland Chen, MD, senior vice president and head of cardiovascular development, Global Drug Development at Bristol Myers Squibb. “We continue to pursue the development of innovative, safe, effective and durable treatment options that improve patients’ lives, and are proud to showcase further analysis from our programs in obstructive hypertrophic cardiomyopathy and thrombosis.”

Key presentations include:

• A featured science presentation of the 32-week follow-up and crossover data from the VALOR-HCM study evaluating mavacamten and the use of septal reduction therapy (SRT)
• A poster presentation surrounding the analysis of pooled safety data from five clinical trials of mavacamten treatment in patients with obstructive and nonobstructive hypertrophic cardiomyopathy
• An oral presentation, sponsored by the Bristol Myers Squibb-Pfizer Alliance, on racial disparities and geographic variation in anticoagulant treatment among Medicare beneficiaries with non-valvular atrial fibrillation in the United States

Summary of Presentations

Select Bristol Myers Squibb and Bristol Myers Squibb-Pfizer Alliance studies at the AHA Annual Scientific Sessions 2022 include:

*Sponsored by the Bristol Myers Squibb-Pfizer Alliance

About CAMZYOS (mavacamten)

CAMZYOS (mavacamten) is the first and only cardiac myosin inhibitor approved by the U.S. Food and Drug Administration (FDA) indicated for the treatment of adults with symptomatic New York Heart Association (NYHA) class II-III obstructive hypertrophic cardiomyopathy (HCM) to improve functional capacity and symptoms. CAMZYOS is an allosteric and reversible inhibitor selective for cardiac myosin. CAMZYOS modulates the number of myosin heads that can enter “on actin” (power-generating) states, thus reducing the probability of force-producing (systolic) and residual (diastolic) cross-bridge formation. Excess myosin actin cross-bridge formation and dysregulation of the super-relaxed state are mechanistic hallmarks of HCM. CAMZYOS shifts the overall myosin population towards an energy-sparing, recruitable, super-relaxed state. In HCM patients, myosin inhibition with CAMZYOS reduces dynamic LVOT obstruction and improves cardiac filling pressures.

IMPORTANT SAFETY INFORMATION

WARNING: RISK OF HEART FAILURE

CAMZYOS reduces left ventricular ejection fraction (LVEF) and can cause heart failure due to systolic dysfunction.

Echocardiogram assessments of LVEF are required prior to and during treatment with CAMZYOS. Initiation of CAMZYOS in patients with LVEF