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Bristol Myers Squibb Research at ESMO Congress 2022 Highlights Depth of Development Program Across Early- and Late-Stages of Cancer

Published: 2022-09-05 10:59:00 ET

Long-term data continue to reinforce benefits of Opdivo (nivolumab)-based combinations

Response outcomes data continue to build upon the clinical evidence of Opdualag (nivolumab and relatlimab-rmbw) in advanced melanoma

Exploratory analyses in non-small cell lung cancer and urothelial carcinoma support the potential benefit of immunotherapy in earlier stages of cancer

PRINCETON, N.J.--(BUSINESS WIRE)-- Bristol Myers Squibb (NYSE: BMY) today announced the presentation of scientific research across several solid tumors showcasing the breadth of the Company’s oncology development program at the European Society for Medical Oncology (ESMO) Congress 2022 from September 9-13 in Paris, France. Over 90 Bristol Myers Squibb-sponsored studies, investigator-sponsored studies, and collaborations will be presented at the Congress. Presentations will include data across our oncology portfolio, such as data that support the role of Opdivo-based approaches in earlier stages of cancer, reinforce the durable long-term survival and health-related quality of life benefits of Opdivo-based combinations, and further demonstrate the benefit of LAG-3 blocking antibody combinations in melanoma with Opdualag.

“Research at this year’s ESMO reinforces the depth and breadth of our development program, spanning from earlier to late stages of cancer. Our robust clinical research program and transformative science is helping to drive improved long-term outcomes for people living with cancer,” said Samit Hirawat, M.D., executive vice president, chief medical officer, Global Drug Development, Bristol Myers Squibb. “We look forward to sharing data that highlight our strategic approach to drug development in oncology, as well as coming together with the scientific community to exchange information about how the critical work in this field can continue to better the lives of patients.”

Key data highlighting approved or investigational therapies from Bristol Myers Squibb at ESMO 2022 include:

Exploratory analyses from CheckMate -816 evaluating neoadjuvant Opdivo with platinum-doublet chemotherapy in patients with resectable non-small cell lung cancer, including pathological features analysis and health-related quality of life outcomes.
Biomarker analyses from CheckMate -274 evaluating adjuvant Opdivo in patients with muscle-invasive urothelial carcinoma, including tumor and immune features associated with disease-free survival.
Exploratory analyses from CheckMate -915 evaluating adjuvant Opdivo and Opdivo plus Yervoy in patients with stage IIIB-D/IV melanoma, including the association of pre-treatment ctDNA with disease recurrence and clinical and translational factors.
Four-year update and biomarker analyses from CheckMate -743 evaluating first-line Opdivo plus Yervoy vs. chemotherapy in patients with unresectable malignant pleural mesothelioma.
Exploratory analysis from CheckMate -9LA evaluating Opdivo plus Yervoy with two cycles of chemotherapy vs. chemotherapy alone in patients with metastatic non-small cell lung cancer and tumor PD-L1 expression

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