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Emgality® Demonstrates Reduction in Frequency, Duration, and Pain Severity in Patients with Episodic and Chronic Migraine

Published: 2020-06-17 10:45:00 ET

INDIANAPOLIS, June 17, 2020 /PRNewswire/ -- Emgality® (galcanezumab-gnlm) reduces total pain burden in a recent analysis of patients with episodic and chronic migraine. Total pain burden is a patient-centric measure that combines the monthly frequency, duration, and pain severity of migraine. Additionally, total pain burden demonstrated significant associations with patient functioning and quality of life. Eli Lilly and Company's (NYSE: LLY) Emgality is the first and only migraine preventive CGRP medication to be assessed in this manner, providing a more complete picture of how Emgality reduced frequency, duration, and severity of migraine pain. These results were presented virtually at the 62nd American Headache Society Congress during National Migraine Awareness Month and at the 72nd American Academy of Neurology Annual Meeting in April (click here for the abstract).

"Total pain burden moves beyond the current and somewhat limited approach for describing migraine pain," said Gudarz Davar, M.D., vice president, neurology development, Lilly Bio-Medicines. "We're delighted that Emgality reduced the combined impact of migraine frequency, duration, and pain severity. We believe that viewing migraine through the lens of total pain burden provides a more holistic approach for people with migraine and doctors to discuss the personal pain experience."

This post hoc analysis of Emgality versus placebo used data from three randomized, double-blind studies in patients with episodic migraine (two pooled six-month studies – EVOLVE-1 and EVOLVE-2; Emgality n=435, placebo n=872) and chronic migraine (one three-month study – REGAIN; Emgality n=273, placebo n=535). Patients reported their headache frequency, duration, and severity using an electronic diary. Monthly total pain burden was calculated as severity-weighted duration by multiplying hours of migraine recorded and pain severity (0=none, 1=mild, 2=moderate, 3=severe) for each migraine day and summing these composite measurements over the migraine days in a month.

The mean change from baseline in monthly total pain burden was compared between Emgality and placebo groups. Patients on Emgality experienced statistically fewer severity-weighted hours of pain than at baseline at each month compared with patients on placebo (p

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All statements made via social media sites sponsored or maintained by Enhanced Investments and its affiliates are for informational purposes only and do not constitute a comprehensive description of Enhanced Investments' investment advisory services.
Certain investments are not suitable for all investors. Before investing, consider your investment objectives and applicable fees. The rate of return on investments can vary widely over time, especially for long term investments. Investment losses are possible, including the potential loss of all amounts invested. Information provided by Enhanced Investments is for informational and general educational purposes only and is not investment or financial advice.