-  Five-year results from SELECT-COMPARE evaluating the efficacy and safety of RINVOQ® (upadacitinib) and HUMIRA® (adalimumab), both in combination with methotrexate (MTX), are reported for adult patients with moderate to severely active rheumatoid arthritis (RA) who had an inadequate response to MTX1

-  Three-year results from SELECT-PsA 1 evaluating the efficacy and safety of RINVOQ are reported in psoriatic arthritis (PsA) patients with prior inadequate response (IR) or intolerance to one or more non-biologic disease-modifying antirheumatic drugs (DMARDs)2

-  One-year efficacy and safety data of RINVOQ are reported in SELECT-AXIS 2 for patients with active ankylosing spondylitis (AS) who had an inadequate response to biologic DMARD therapy3

NORTH CHICAGO, Ill., May 24, 2023 /PRNewswire/ -- AbbVie (NYSE: ABBV) today announced that researchers will present new, long-term data supporting the efficacy and safety profile of RINVOQ® (upadacitinib) from the SELECT-COMPARE, SELECT-PsA 1 and SELECT-AXIS 2 studies at the European Congress of Rheumatology, EULAR 2023, taking place from 31 May – 3 June in Milan.

"These new results from the SELECT trial programs continue to strengthen the breadth of evidence available for RINVOQ's efficacy and safety profile in several rheumatic diseases," said Mudra Kapoor, vice president, global medical affairs, immunology, AbbVie. "Our investment in long-term data is an essential part of AbbVie's ongoing commitment to ensure we are supporting patients living with immune-mediated diseases."

Long-term data supporting the efficacy and safety profile of RINVOQ that will be presented at the EULAR 2023 Congress include more than 20 clinical endpoints and safety data from approximately 2,450 patients representing more than 6,700 patient-years across rheumatoid arthritis (RA), psoriatic arthritis (PsA), and ankylosing spondylitis (AS).1,2,3

"The impact of rheumatic diseases, such as rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis, can be life-long and deeply affect a patient's quality of life," said Roy Fleischmann, M.D., SELECT-COMPARE study investigator and clinical professor of medicine, University of Texas Southwestern Medical Center, co-medical director, Metroplex Clinical Research Center. "These efficacy and safety data provide additional information to help healthcare providers make important treatment choices with their patients and highlight the ability to maintain disease control with long-term treatment."

Highlights from these trials include:

Long-Term Safety and Efficacy of Upadacitinib or Adalimumab in Patients with Rheumatoid Arthritis: Five-Year Data From the SELECT-COMPARE StudyPOS0849. Thurs, 1 June; 14:45-15:45 CESTThe abstract reported the safety and efficacy of RINVOQ and HUMIRA across five years in adult patients with moderate to severely active RA who had an inadequate response to methotrexate (MTX), as part of the ongoing long-term extension (LTE) of SELECT-COMPARE. Patients receiving background MTX were randomized to receive RINVOQ 15 mg once daily, HUMIRA 40 mg every other week or placebo and those who completed the 48-week double-blind period could continue to receive open label RINVOQ or HUMIRA in the LTE up to 10 years. Efficacy endpoints included Clinical Disease Activity Index (CDAI) low disease activity (LDA), CDAI remission, and disease activity scores based on 28 joints and C-reactive protein (DAS28[CRP]) ≤ 3.2 (LDA) and