SYGNIA ITRIX COLLECTIVE INVESTMENT SCHEME Sygnia Itrix Solactive Healthcare 150 ETF JSE Code: SYGH ISIN: ZAE000300521 A portfolio in the Sygnia Itrix Collective Investment Scheme in Securities, registered as such in terms of the Collective Investment Schemes Control Act, 45 of 2002. INDEX CONSTITUENT CHANGE - SYGH In terms of section 19.28 of the JSE Limited Listings Requirements, notice is hereby given to investors of the above ETF securities that the following changes in the constituents of the underlying index in the table below is effective from 09 May 2022. The following constituents have been added to SYGH: Previous Share New Weight ISIN Weight US00404A1097 ACADIA HEALTHCARE CO INC 0.00% 0.09% US30161Q1040 EXELIXIS INC 0.00% 0.09% US3795772082 GLOBUS MEDICAL INC 0.00% 0.07% US4577301090 INSPIRE MEDICAL SYSTEMS INC 0.00% 0.07% US8036071004 SAREPTA THERAPEUTICS INC 0.00% 0.08% US82489T1043 SHOCKWAVE MEDICAL INC 0.00% 0.06% The following constituents have been removed from SYGH: Previous Share New Weight ISIN Weight US29082K1051 EMBECTA CORP ORD 0.02% 0.00% FR0014008VX5 EUROAPI SAS 0.01% 0.00% US37611X1000 GINKGO BIOWORKS HOLDINGS INC 0.04% 0.00% US45826J1051 INTELLIA THERAPEUTICS INC 0.04% 0.00% US60468T1051 MIRATI THERAPEUTICS INC 0.04% 0.00% US6323071042 NATERA INC 0.04% 0.00% US6700024010 NOVAVAX INC 0.06% 0.00% US98888T1079 ZIMVIE INC 0.01% 0.00% The above gave affect to changes in the index constituent weights. The portfolio composition file can be viewed at: www.sygnia.co.za/etfs/etf-and-etn-fund-range. 09 May 2022 Manager Sygnia Itrix (RF) Pty Limited JSE Sponsor Vunani