SYGNIA ITRIX COLLECTIVE INVESTMENT SCHEME Sygnia Itrix Solactive Healthcare 150 ETF JSE Code: SYGH ISIN: ZAE000300521 A portfolio in the Sygnia Itrix Collective Investment Scheme in Securities, registered as such in terms of the Collective Investment Schemes Control Act, 45 of 2002. INDEX CONSTITUENT CHANGE - SYGH In terms of section 19.28 of the JSE Limited Listings Requirements, notice is hereby given to investors of the above ETF securities that the following changes in the constituents of the underlying index in the table below is effective from 03 November 2022. The following constituents have been added to SYGH: Previous Share Name New Weight ISIN Weight US03753U1060 APELLIS PHARMACEUTICALS INC 0.00% 0.08% US4622221004 IONIS PHARMACEUTICALS INC 0.00% 0.09% US48576A1007 KARUNA THERAPEUTICS INC 0.00% 0.08% US5165441032 LANTHEUS HOLDINGS INC 0.00% 0.07% JP3869010003 MATSUKIYOCOCOKARA & CO 0.00% 0.06% US68404L2016 OPTION CARE HEALTH INC 0.00% 0.07% The following constituents have been removed to SYGH: Previous Share Name New Weight ISIN Weight GB0009633180 DECHRA PHARMACEUTICALS PLC 0.05% 0.00% FR0014000MR3 EUROFINS SCIENTIFIC SE 0.12% 0.00% SE0000202624 GETINGE AB CLASS B 0.06% 0.00% ES0171996087 GRIFOLS SA CLASS A 0.04% 0.00% IE0005711209 ICON PLC 0.22% 0.00% VGG1110E1079 NEW BIOHAVEN 0.01% 0.00% US87918A1051 TELADOC HEALTH INC 0.06% 0.00% The above gave affect to changes in the index constituent weights. The portfolio composition file can be viewed at www.sygnia.co.za/etfs/etf-and-etn-fund-range. 03 November 2022 Manager Sygnia Itrix (RF) Pty Limited JSE Sponsor Vunani