ASPEN PHARMACARE HOLDINGS LIMITED (Incorporated in the Republic of South Africa) (“Aspen Holdings”) Registration number: 1985/002935/06 Share code: APN ISIN: ZAE000066692 LEI: 635400ZYSN1IRD5QWQ94 and its subsidiaries (collectively “Aspen” or “the Group”) ASPEN, CEPI AND THE BILL & MELINDA GATES FOUNDATION EXPAND COMMITMENTS TO IMPROVE ACCESS TO VACCINES IN AFRICA On 31 August 2022 Aspen announced that: - an agreement had been reached with the Serum Institute of India Pvt Ltd (“Serum Institute”) which provided Aspen with a license to the enabling know how, allowing its South African manufacturing operations to manufacture, market and distribute four routine vaccines in Africa; and - Aspen had been negotiating the receipt of grant funding from each of the Bill & Melinda Gates Foundation (“the Gates Foundation”) and the Coalition for Epidemic Preparedness Innovations (“CEPI”) to support African regional manufacturing capacity for an affordable supply of vaccines. Aspen now has pleasure in confirming that it has concluded a set of agreements with the Gates Foundation and CEPI to receive the USD30 million funding to support its capabilities to manufacture lifesaving routine and outbreak vaccines for Africa. The new funding from CEPI and the Gates Foundation, which includes USD15 million from each organization, will support a ten-year agreement between Aspen and Serum Institute that aims to expand the supply and sourcing of affordable vaccines manufactured in Africa. Through the partnership with Serum Institute, Aspen will manufacture and distribute four routine vaccines in Africa — Pneumococcal, Rotavirus, Poly valent Meningococcal, and Hexavalent — with the technology transfer activities initiating in early 2023. In addition to supporting the technology transfer of these routine vaccines, the funding from CEPI and the Gates Foundation will help to sustain regional vaccine manufacturing capacity at Aspen for potential future outbreak response, with the intention of securing early access to African-produced vaccines in the event of a future public health emergency. Durban 12 December 2022 Sponsor Investec Bank Limited